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A comprehensive review on microemulsions

By: Aysha Aslam, Saad bin zulfiqar, Javeid Iqbal, Rushda Bedar

Key Words: Microemulsions, Surfactant, Pharmaceuticals, Oil, Cosmetics.

Int. J. Biosci. 18(2), 163-173, February 2021.

DOI: http://dx.doi.org/10.12692/ijb/18.2.163-173

Certification: ijb 2021 0168 [Generate Certificate]

Abstract

Microemulsions are thermodynamically stable, transparent and isotropic liquid mixtures which are consisted of oil, water and surfactant. The particle size of the microemulsions may range from 10 to 300 nanometers. In this review, properties, structure, types, theories, characterization and applications of the microemulsions are discussed in detail. They can be prepared simply by mixing the different components without specific equipment and conditions. In w/o type, oil is the continuous phase and water as droplets are dispersed in it, whereas in o/w type microemulsion there is an aqueous continuous phase and oil droplets are dispersed in it. Microemulsions are widely used in pharmaceutical industries, cosmetics and analytical techniques. Microemulsions permit self-emulsification owing to the thermodynamically stable system and are utilized for the palatability of unpleasant drugs. The characterization of the microemulsions can be done by various methods, including microscopy, nuclear magnetic resonance and light scattering methods. Comprehensive knowledge of microemulsions will guide their physicochemical and biopharmaceutical properties that could be beneficial in designing the drug formulations and cosmetics.

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A comprehensive review on microemulsions

Agrawal OP, Agrawal S. 2012. An overview of new drug delivery system: microemulsion. Asian Journal of Pharmaceutical Sciences 2(1), 5-12.

http://www.ajpst.com/File_Folder/5-12.pdf

Awad TS, Asker D, Romsted LS. 2018. Evidence of coexisting microemulsion droplets in oil-in-water emulsions revealed by 2D DOSY 1H NMR. Journal of Colloid and Interface Science 514, 83-92.

https://doi.org/10.1016/j.jcis.2017.12.024

Bardhan S, Kundu K, Chakraborty G, Paul BK, Moulik SP, Saha SK. 2016. Bioinspired Microemulsions and Their Strategic Pharmacological Perspectives. Encyclopedia of Biocolloid and Biointerface Science 19, 122-44.

https://doi.org/10.1002/9781119075691.ch10

Cadogan SP, Hahn CJ, Rausch MH, Fröba AP. 2017. Study on the applicability of dynamic light scattering (DLS) to microemulsions including supercritical carbon dioxide-swollen micelles. Journal of Colloid and Interface Science 499, 202-8.

https://doi.org/10.1016/j.jcis.2017.03.111

Callender SP, Mathews JA, Kobernyk K, Wettig SD. 2017. Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. International Journal of Pharmaceutics 526(1-2), 425-42.

https://doi.org/10.1016/j.ijpharm.2017.05.005

Cespi M, Quassinti L, Perinelli DR, Bramucci M, Iannarelli R, Papa F, Ricciutelli M, Bonacucina G, Palmieri GF, Maggi F. 2017. Microemulsions enhance the shelf‐life and processability of Smyrnium olusatrum L. essential oil. Flavour and Fragrance Journal 32(3), 159-64.

https://doi.org/10.1002/ffj.3367

Chai JL, Sun B, Chai ZQ, Liu N, Pan J, Lu JJ. 2017. Comparisions of the effects of temperature on the W/O microemulsions formed by alkyl imidazole gemini and imidazole ionic liquids type surfactants. Journal of Dispersion Science and Technology 38(7), 967-72. https://doi.org/10.1080/01932691.2016.1216439

Chang L, Pope GA, Jang SH, Tagavifar M. 2019. Prediction of microemulsion phase behavior from surfactant and co-solvent structures. Fuel 237, 494-514.

https://doi.org/10.1016/j.fuel.2018.09.151

Chen J, Ma XH, Yao GL, Zhang WT, Zhao Y. 2018. Microemulsion-based anthocyanin systems: effect of surfactants, cosurfactants, and its stability. International Journal of Food Properties 21(1), 1152-65.

https://doi.org/10.1080/10942912.2018.1485032

Danielsson I. 1981. The definition of microemulsion. Pascal and Francis Bibliographic Databases.

http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=PASCAL82X0076549

Das S, Lee SH, Chow PS, Macbeath C. 2020. Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. Colloids and Surfaces B: Biointerfaces 30, 111161.

https://doi.org/10.1016/j.colsurfb.2020.111161

Du Z, Mao X, Tai X, Wang G, Liu X. 2016. Preparation and properties of microemulsion detergent with linear medium chain fatty alcohols as oil phase. Journal of Molecular Liquids 223, 805-10. https://doi.org/10.1016/j.molliq.2016.09.011

Gadhave AD, Waghmare JT. 2014. A short review on microemulsion and its application in extraction of vegetable oil. International Journal of Research in Engineering and Technology 3(9), 147-58.

https://ijret.org/volumes/2014v03/i09/IJRET20140309022.pdf

Hejazifar M, Lanaridi O, Bica-Schröder K. 2020. Ionic liquid based microemulsions: A review. Journal of Molecular Liquids 303, 112264.

https://doi.org/10.1016/j.molliq.2019.112264

Hou M, Dang L, Liu T, Guo Y, Wang Z. 2017. Novel fluorescent microemulsion: Probing properties, investigating mechanism, and unveiling potential application. ACS Applied Materials & Interfaces 9(31), 25747-54.

https://doi.org/10.1021/acsami.7b05819

Hou W, Xu J. 2016. Surfactant-free microemulsions. Current Opinion in Colloid & Interface Science 25, 67-74.

https://doi.org/10.1016/j.cocis.2016.06.013

Jagtap SR, Phadtare DG, Saudagar RB. 2016. Microemulsion: A Current Review. Research Journal of Pharmaceutical Dosage Forms and Technology 8(2), 161-70.

http://dx.doi.org/10.5958/0975-4377.2016.00021.5

Lee KL. 2011. Applications and use of microemulsions. Chemical Physics 13.

https://arxiv.org/abs/1108.2794

Leng L, Han P, Yuan X, Li J, Zhou W. 2018. Biodiesel microemulsion upgrading and thermogravimetric study of bio-oil produced by liquefaction of different sludges. Energy 153, 1061-72

https://doi.org/10.1016/j.energy.2018.04.087

Liu H, Mei J, Xu Y, Tang L, Chen D, Zhu Y, Huang S, Webster TJ, Ding H. 2019. Improving The Oral Absorption Of Nintedanib By A Self-Microemulsion Drug Delivery System: Preparation And In Vitro/In Vivo Evaluation. International Journal of Nanomedicine 14, 8739.

https://dx.doi.org/10.2147%2FIJN.S224044

Lokhande SS. 2019. Microemulsions as Promising Delivery Systems: A Review. Asian Journal of Pharmaceutical Research 9(2), 90-6.

http://dx.doi.org/10.5958/2231-5691.2019.00015.7

Mishra A, Ridhi P, Rana AC. 2014. Microemulsions: As drug delivery system.” Journal of Scientific and Innovative Research 3(4), 467-474.

http://www.jsirjournal.com/Vol3_Issue4_12.pdf

Muzaffar FA, Singh UK, Chauhan L. 2013. Review on microemulsion as futuristic drug delivery. International Journal of Pharmacy and Pharmaceutical Sciences 5(3), 39-53.

Oberdisse J, Hellweg T. 2017. Structure, interfacial film properties, and thermal fluctuations of microemulsions as seen by scattering experiments. Advances in Colloid and Interface Science 247, 354-62.

https://doi.org/10.1016/j.cis.2017.07.011

Paliwal H, Solanki RS, Chauhan CS, Dwivedi J. 2019. Pharmaceutical considerations of microemulsion as a drug delivery system. Journal of Drug Delivery and Therapeutics 9(4-s), 661-5.

https://doi.org/10.22270/jddt.v9i4-s.3206

Pourtabrizi M, Shahtahmassebi N, Kompany A, SHarifi S. 2018. Effect of microemulsion structure on fluorescence and nonlinear optical properties of rhodamine 6G. Journal of Fluorescence 28(1), 323-36.

https://doi.org/10.1007/s10895-017-2195-y

Roohinejad S, Oey I, Everett DW, Greiner R. 2018. Microemulsions. Emulsion‐based Systems for Delivery of Food Active Compounds: Formation, Application, Health and Safety 23, 231-62.

https://doi.org/10.1002/9781119247159.ch9

Saini JK, Nautiyal U, Kumar M, Singh D, Anwar F. 2014. Microemulsions: A potential novel drug delivery system. International Journal of Pharmaceutical and Medicinal Research 2(1), 15-20.

https://ijpmr.org/pdf/Microemulsions-A-potential-novel-drug-delivery-system.pdf

Salager JL, Antón R, Bullón J, Forgiarini A, Marquez R. 2020. How to use the normalized hydrophilic-lipophilic deviation (HLDN) concept for the formulation of equilibrated and emulsified surfactant-oil-water systems for cosmetics and pharmaceutical products. Cosmetics 7(3), 57.

https://doi.org/10.3390/cosmetics7030057

Sharma N, Antil V, Jain S. 2013. Microemulsion: A review. Asian Journal of Pharmaceutical Research and Development 1, 23-36.

http://www.ajprd.com/index.php/journal/article/view/43

Shukla T, Upmanyu N, Agrawal M, Saraf S, Saraf S, Alexander A. 2018. Biomedical applications of microemulsion through dermal and transdermal route. Biomedicine & Pharmacotherapy 108, 1477-94.

https://doi.org/10.1016/j.biopha.2018.10.021

Singh PK, Iqubal MK, Shukla VK, Shuaib M. 2014. Microemulsions: current trends in novel drug delivery systems. Journal of Pharmaceutical, Chemical and Biological Sciences 1(1), 39-51.

Sujatha B, Himabindu E, Bttu S, Abbulu K. 2020, Microemulsions-A review. Journal of Pharmaceutical Sciences and Research 12(6), 750-3. https://www.jpsr.pharmainfo.in/Documents/Volumes/vol12issue06/jpsr12062003.pdf

Talegaonkar S, Azeem A, Ahmad FJ, Khar RK, Pathan SA, Khan ZI. 2008. Microemulsions: a novel approach to enhanced drug delivery. Recent Patents on Drug Delivery & Formulation 2(3), 238-57.

https://doi.org/10.2174/187221108786241679

Winsor PA. 1948. Hydrotropy, solubilisation and related emulsification processes. Transactions of the Faraday Society 44, 376-98.

https://pubs.rsc.org/en/content/articlelanding/1948/tf/tf9484400376/unauth#!divAbstract

Zhao J, Jiang K, Chen Y, Chen J, Zheng Y, Yu H, Zhu J. 2020. Preparation and Characterization of Microemulsions Based on Antarctic Krill Oil. Marine drugs 18(10), 492.

https://doi.org/10.3390/md18100492

Aysha Aslam, Saad bin zulfiqar, Javeid Iqbal, Rushda Bedar.
A comprehensive review on microemulsions.
Int. J. Biosci. 18(2), 163-173, February 2021.
https://innspub.net/ijb/a-comprehensive-review-on-microemulsions/
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