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Anti-diabetic effect of Ceylon cinnamon aqueous extract against blood glucose, lipid profile and hematological parameters in male diabetic rats

By: Asia Parveen, Khan Arbaz Ali, Muhammad Maisam, Nureen Zahra, Rabail Alam, Modasrah Mazhar, Ayesha shaukat

Key Words: Cinnamon extract, alloxan, hypoglycemic, antilipidemic, hematological indices.

Int. J. Biosci. 13(6), 169-175, December 2018.

DOI: http://dx.doi.org/10.12692/ijb/13.6.169-175

Certification: ijb 2018 0069 [Generate Certificate]

Abstract

Diabetes mellitus is a multifactorial endocrine pathology appears mainly with hyperglycemia and disturbed lipid profile. Cinnamon is well known in Asian and Middle East countries for their antidiabetic activity. Main objective was the evaluation of antidiabetic spice cinnamon on diabetes mellitus in terms of blood glucose, lipid profile and hematological parameters. Male albino rats (Rattus norvegicus) ageing 10 – 12 weeks and weighting 163-170g were made diabetic with alloxan via intra-peritoneal injection.Rats were divided into four groups each group consist of three rats. Group A is control group, Group B served as negative or diabetic group. Group C Served as cinnamon treated group with 500 mg/kg body of weight of cinnamon extract, Group D served as positive group treated with secretagogue glimepiride. During 14 days of research rats were daily medicated via orally. At the end of study starved rats were anesthetized and dissected for the collection of blood samples. Blood glucose significantly (P<0.005) reduced in cinnamon extract treated rats after 7 and 14 days of treatment as compare to diabetic rats. Total cholesterol, triglycerides and low density lipoproteins also significantly (P<0.05) reduced in cinnamon extract treated group. While hematological parameters total erythrocyte count (TLC) and hemoglobin (HB) were only improved insignificantly in Group C. Cinnamon has significant hypoglycemic and antilipidemic effects to cure diabetes and diabetes induced dyslipidemia. Cinnamon extract has no toxic effects on hematological parameters. Further studies are required to evaluate the mode of action and longtime toxicity effects of extract on kidney and liver.

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Anti-diabetic effect of Ceylon cinnamon aqueous extract against blood glucose, lipid profile and hematological parameters in male diabetic rats

Ahmed AM. 2002. History of diabetes mellitus. Saudi Medical Journal 23, 373-378.

Shera AS, Basit A, Fawwad A. 2010. Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in the Punjab Province of Pakistan. Primary Care Diabetes 4(2), 79-83.

Low wang CC, Hess CN, Hiatt WR, Goldfine AB. 2016. Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus -Mechanisms, Management, and Clinical Considerations. Circulation 133(24), 2459-502.

Joseph JJ, Echouffo tcheugui JB, Effoe VS, Hsueh WA, Allison MA, Golden SH. 2018. Renin-Angiotensin-Aldosterone System, Glucose Metabolism and Incident Type 2 Diabetes Mellitus: MESA. Journal of the American Heart Association 7 (17), e009890.

Varvaki rados D, Catani pinto L, Reck remonti L, Bauermann leitão C, Gross JL. 2016. The Association between Sulfonylurea Use and All-Cause and Cardiovascular Mortality: A Meta-Analysis with Trial Sequential Analysis of Randomized Clinical Trials. PLOS Medicine 13(4), e1001992.

Medagama AB. 2015. The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. Nutrition Journal 14, 108.

Kirkham S, Akilen R, Sharma S, Tsiami A. 2009. The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance. Diabetes, Obesity & Metabolic Disorders 11(12), 1100–13.

Jarvill-taylor KJ, Anderson RA, Graves DJ. 2001. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. Journal of the American College of Nutrition 20(4), 327-36.

Gushiken LF, Beserra FP, Rozza AL, Bérgamo PL, Bérgamo DA, Pellizzon CH. 2016. Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects. The Review of Diabetic Studies 13(2-3), 96-112.

Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the Concentration of Low- Density Lipoprotein Cholesterol in Plasma, without use of the Preparative Ultracentrifuge. Clinical Chemistry 18(6), 499-502.

Thomas MC, Macisaac RJ, Tsalamandris C. 2004. Anemia in patients with type diabetes. The Journal of Clinical Endocrinology and Metabolism 89(9), 4359-4363.

Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. 2007. Effect of cinnamon on glucose and lipid levels in non-insulin-dependent type 2 diabetes. Diabetes Care 30(9), 2236–2237.

Abdulrahim Al-Jamal, Imad Naji Rasheed, 2010. Effects of cinnamon (Cassia zelynicum) on diabetic rats. African Journal of Food Science and Technology 4(9), 615–617.

MacRury SM, Lowe GD. 1990. Blood rheology in diabetes mellitus. Diabetic Medicine 7, 285–291.

Baron AD, Steinberg H, Brechtel G, Johnson A. 1994. Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. American journal of physiology 266, 248–253.

Asia Parveen, Khan Arbaz Ali, Muhammad Maisam, Nureen Zahra, Rabail Alam, Modasrah Mazhar, Ayesha shaukat.
Anti-diabetic effect of Ceylon cinnamon aqueous extract against blood glucose, lipid profile and hematological parameters in male diabetic rats.
Int. J. Biosci. 13(6), 169-175, December 2018.
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