International network for natural sciences – research journal
  • mendeley icon
  • linkedin icon
  • google plus icon
  • twitter icon
  • google scholar icon
  • facebook icon

Anticancer activity of ethnobotanicals of the Philippine Ilongot-Eǵongot community on human colon cancer cells (HCT-116)

By: Earl Jericho DJ. Cachin, Glenn G. Oyong, Khristina G. Judan Cruz

Key Words: Ethnobotanicals, HCT-116, Colon cancer, Ilongot-eǵongot.

Int. J. Biosci. 15(1), 235-240, July 2019.

DOI: http://dx.doi.org/10.12692/ijb/15.1.235-240

Certification: ijb 2019 0034 [Generate Certificate]

Abstract

Globally, colon cancer is one of the leading causes of cancer deaths. Colon carcinoma is one of the best-understood neoplasms from the genetic perspective, yet it remains the second most cause of cancer-related deaths. As one of the developing countries, Philippines possess a rich biodiversity that offers wide range of ethnobotanicals waiting to be utilized for cancer treatment. Ethanolic extracts of ten ethnobotanicals collected from the Ilongot-Eǵongot community of Bayanihan, Maria Aurora, and Aurora, Philippines were tested against human colon cancer cell line HCT-116. Cell viability and cytotoxicity was determined using the PrestoBlue® Assay. The assay revealed that Premna odorata (Local Name: Asedaong; IC50 0.8747 μg/ml), Dillenia philippinensis(Local Name: Katmon; IC50 0.6358 μg/ml), Eleusine indica (Local name: Pag; IC50 0.6653 μg/ml), Mikania micrantha (Local Name: Ola ola; IC50 0.8201 μg/ml), Diplazium esculentum (Local name: Pako Pako; IC50 0.7338 μg/ml), Urena lobata(Local name: Pukot; IC50 1.009 μg/ml), Hydrocotyle vulgaris(Local name: Gotukola; IC50 0.8788 μg/ml), Ceiba pentandra (Local name: Betek; IC50 1.04 μg/ml), Adenanthera intermedia(Local name: Kares; IC50 1.295 μg/ml) and Stachytarpheta sp. (Local Name: Luzviminda; IC50 1.322 μg/ml), showed anticancer activity against human colon cancer cell line (HCT-116). All extracts showed an IC50 <20 µg/mL which is considered as highly toxic.

| Views 64 |

Anticancer activity of ethnobotanicals of the Philippine Ilongot-Eǵongot community on human colon cancer cells (HCT-116)

Alfonso FR. 2015. α-Glucosidase Inhibitory Activity of Selected Ethnobotanicals of Imugan, Nueva Vizcaya. An Undergraduate Thesis. Central Luzon State University, Science City of Muñoz, Nueva Ecija, Philippines.

Balangcod TD, Balangcod AK. 2011. Ethnomedical Knowledge of Plants and Healthcare Practices among the Kalanguya Tribe in Tinoc, Ifugao, Luzon, Philippines. Indian Journal of Traditional Knowledge 10(2), 227-238.

Barrogo KN, Jacinto WR, Judan Cruz KG. 2018. Quorum sensing-inhibition activities of Philippine ethnobotanicals against virulence factors in Pseudomonas aeruginosa.International Journal of Biosciences 13(4), 173-182

De Los Reyes M, Oyong GG, Ebajo VD, Ng VAS, Shen CC, Ragasa CY. 2015. Cytotoxic Triterpenes and Sterols from Pipturus arborescens (Link) CB Rob. Journal of Applied Pharmaceutical Science 5(11), 023-030.

Divina RBKM. 2015. Antioxidant Screening of Ethnobotanicals of Imugan, Nueva Vizcaya, Philippines. An Undergraduate Thesis. Central Luzon State University, Science City of Muñoz, Nueva Ecija, Philippines.

Freshney RI. 2005. Biology of Cultured Cells. Culture of Animal Cells: A Manual of Basic Techniques. Wiley-Liss, Inc., New York, USA.

Jose KJC. 2015. Xanthine Oxidase Inhibition of the Selected Ethnobotanicals of Imugan, Nueva Vizcaya. An Undergraduate Thesis. Central Luzon State University, Science City of Muñoz, Nueva Ecija, Philippines.

Judan Cruz KJ, Gabriel CM, Abella EAA. 2018.  Biological Activities of philippine Ethnotoxic PLANTS. International Journal of Biology, Pharmacy and Allied Sciences 7(5), 709-718.

https://doi.org/10.31032/IJBPAS/2018/7.5.4430

Limos GB, Jacinto WR, Judan Cruz KG. 2018.  Philippine ethnobotanicals inhibit virulence factors in Staphylococcus aureus 13(5), 178-187.

Mohan K, Jeyachandran R, Deepa R. 2012. Alkaloids as Anticancer Agents. Annals of Phytomedicine 1(1), 46-53.

O’brien CA, Pollett A, Gallinger S, Dick JE.  2007. A Human Colon Cancer Cell Capable of Initiating Tumor Growth in Immunodeficient Mice. Nature 445, 106-110.

Padilla KGV, Jacinto WR, Judan Cruz KJC.  2018. Quorum Sensing-Mediated α- Hemolysin Inhibition of Philippine Ethnobotanicals INStaphylococcus aureus. International Journal of Biology, Pharmacy and Allied Sciences 7(8), 1537-1550.

https://doi.org/10.31032/IJBPAS/2018/7.8.4512

Pooten E. 2017. Anti-Proliferative and Cytotoxic Activities of Ethnobotanicals from Imugan, Nueva Vizcaya, Philippines against Selected Human Cancer Cells. A Master’s Thesis. Central Luzon State University, Science City of Muñoz, Nueva Ecija, Philippines.

Spilioti E, Jaakkola M, Tolonen T, Lipponen M, Virtanen V. 2014. Phenolic Acid Composition, Antiatherogenic and Anticancer Potential of Honeys Derived from Various Regions in Greece. Public Library of Science One 9(4), 1-10.

Tan LY, Yin WF, Chan KG. 2013. Piper nigrum, Piper betle and Gnetum gnemon-Natural Food Source with Anti-Quorum Sensing Properties. Sensors 13(3), 3975-3985.

Todaro M, Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Peschle C, De Maria R. 2007. Identification and Expansion of Human Colon-Cancer-Initiating Cells. Nature. 445(7123), 111.

Earl Jericho DJ. Cachin, Glenn G. Oyong, Khristina G. Judan Cruz.
Anticancer activity of ethnobotanicals of the Philippine Ilongot-Eǵongot community on human colon cancer cells (HCT-116).
Int. J. Biosci. 15(1), 235-240, July 2019.
https://innspub.net/ijb/anticancer-activity-ethnobotanicals-philippine-ilongot-egongot-community-human-colon-cancer-cells-hct-116/
Copyright © 2019
By Authors and International Network for
Natural Sciences (INNSPUB)
https://innspub.net
brand
innspub logo
english language editing
  • CALL FOR PAPERS
    CALL FOR PAPERS
    Publish Your Article
  • CALL FOR PAPERS
    CALL FOR PAPERS
    Submit Your Article
INNSPUB on FB
Email Update