Antioxidant activity and gastro-protective effets of carob podsa queous extracts on indomethacin-induced gastric ulcer in wistar rats
By: Mansouria Belhocine, Chahrazed Sakmeche, Fatima Azzouz
Key Words: Carob pods, Peptic ulcer, Gastric mucus, Ulcer index, antioxidants.
Int. J. Biosci. 12(6), 48-69, June 2018.
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Gastroduodenal ulcer is a reccurent chronic disease aggravated by the use of non-steroidal anti-inflammatory drugs (NSAIDs), and long-term low-dose aspirin therapy.This study aimed at searching a natural anti-ulcer remedy without side effects. The carob pod antioxidant activity was tested on DPPH and its gastro-protective effect was investigated in Wistar rats submitted to a gastric ulcer, induced by a NSAID drug, indomethacin. The study was performed on twenty rats allocated into four groups. The negative control group received distilled water, the positive control group received indomethacin, the standard group received ranitidine, and group four received carob pods aqueous extract (CPAE). Animals were per-orally pretreated during 15 days, and the indomethacin was administrated the 16th day to all rats, except those of the negative control group. Carob exhibited important antioxidant activity (85%). Indomethacin-ulcerated rats showed congested, odemateus and fissured gastric mucosa by numerous ulcer lesions, an increased ulcer index and significantly decreased adherent gastric mucus content. Pepsin activity and gastric juice volume increased, while pH diminished significantly. CPAE reduced the volume and increased the pH of the gastric juice, and lowered the pepsin activity. Ulcer lesions and ulcer index were strongly lowered. The gastric mucus was reconstituted and the mucosa appeared almost competely healed, with normal color and thickness. The carob protection percentage was similar to that of ranitidine. Carob therefore, undoubtedly has antiulcer potential, through an anti-secretory effect, possibly related to its strong antioxidant capacity. It can be proposed as a therapeutic opportunity in the management of peptic ulcers.
Antioxidant activity and gastro-protective effets of carob podsa queous extracts on indomethacin-induced gastric ulcer in wistar rats
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Antioxidant activity and gastro-protective effets of carob podsa queous extracts on indomethacin-induced gastric ulcer in wistar rats.
Int. J. Biosci. 12(6), 48-69, June 2018.
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