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Assessment of phytochemical constituents, antioxidant activity, cytotoxicity and antiproliferative activity of apricot

By: M. Asghar, M. Gulfraz, M. J. Asad, T. Masud

Key Words: Apricot, MTT, HPLC, FTIR, Flavonoids, Phenolic acids, Antioxidants

Int. J. Biosci. 12(6), 346-354, June 2018.

DOI: http://dx.doi.org/10.12692/ijb/12.6.346-354

Certification: ijb 2018 0075 [Generate Certificate]

Abstract

Medicinal herbs are having decisive role to improve the human health standard because of predominant bioactive constituents. Prunus armeniaca (Apricot) is a highly nutritious fruit with a rich composition of health promoting components with a unique taste. Apricot samples grown in Gilgit Baltistan were assessed for their biochemical attributes, FTIR interferogram profiling, Phytochemicals screening, antioxidant activity, Cytotoxicity, and MTT based antiproliferative activity. HPLC data of fruit extract showed the presence of phenolic acids and flavonoid contents, appreciable quantities of vanillic acid, gallic acid and catechin. These secondary metabolites exhibited rich biochemical and functional activity, significant antioxidant potential and free radicals scavenging activity. FTIR spectra’s were used to obtain information on functional groups and chemical structure of apricot samples showed significant antioxidant activity as well antiproliferative activity against cervical cancer cells (HeLa-S3). Anti-cancer results are also supported by antitumor potato disc assay by significant inhibition of tumor formation.

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Assessment of phytochemical constituents, antioxidant activity, cytotoxicity and antiproliferative activity of apricot

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M. Asghar, M. Gulfraz, M. J. Asad, T. Masud.
Assessment of phytochemical constituents, antioxidant activity, cytotoxicity and antiproliferative activity of apricot.
Int. J. Biosci. 12(6), 346-354, June 2018.
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