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Brain Biomarkers of some Egyptian Children with Autism manifesting poor language development

By: Abdelrahman A. Ramadan, Zakaria El-Khayat, Shadia A. Fathy, Ehab Ragaa Abdelraouf, Marwa G.A. Hegazy

Key Words: Autism, Dopamine, Serotonin, Brain-derived, Neurotrophic factor.

Int. J. Biosci. 17(6), 276-286, December 2020.

DOI: http://dx.doi.org/10.12692/ijb/17.6.276-286

Certification: ijb 2020 0107 [Generate Certificate]

Abstract

Autism is characterized by deficits in social interaction with restricted repetitive patterns of interests during the early developmental period.  Alterations of some biochemical measures were suspected to have a role in autism pathogenesis such as dopamine, serotonin and brain-derived neurotrophic factor.  These measures are important for the development of memory, language and social abilities. Hence, they could be altered in autism. We aimed to measure the blood levels of dopamine, serotonin and brain-derived neurotrophic factor in a group of Egyptian autistic children with language impairment in comparison to healthy control children to investigate the relation between them. The study included 40 children with autism and 20 healthy controls.  The autism and language delay were diagnosed according to the diagnostic and statistical manual of mental disorders. The dopamine and serotonin levels for both groups were determined by high-performance liquid chromatography. The brain-derived neurotrophic factor was measured by ELISA. The level of dopamine in the autism group was less than that in the control group while the brain-derived neurotrophic factor level was higher in the autism group. Investigating the relation between dopamine and the brain-derived neurotrophic factor in the autism group revealed a statistically significant positive correlation (r=0.5, p<0.01). In conclusion, the dopamine and the brain-derived neurotrophic factor could have a role in the pathogenesis of autism. These measures could be used as diagnostic biomarkers for children suspected to have autism.

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Brain Biomarkers of some Egyptian Children with Autism manifesting poor language development

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Abdelrahman A. Ramadan, Zakaria El-Khayat, Shadia A. Fathy, Ehab Ragaa Abdelraouf, Marwa G.A. Hegazy.
Brain Biomarkers of some Egyptian Children with Autism manifesting poor language development.
Int. J. Biosci. 17(6), 276-286, December 2020.
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