Cardio protective effects of dates
By: Sidra Khalid, Misbah Arshad, Barira Saad, Muhammad Imran, Huma Bader Ul Ain, Tabussam Tufail, Muhammad Zia Shahid, Muhammad Atif, Muhammad Ikram Ullah, Sheraz Ahmed
Key Words: Date palm, Phytochemicals, Antioxidant, Cardiovascular role, lipid lowering effect.
Int. J. Biosci. 16(5), 110-123, May 2020.
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Date palm (Phoenix dactylifera L.) fruit is promising and significant source of high nutritional value compounds such as carbohydrates, proteins, dietary fibers, minerals, and vitamins as well as also enrich by anthocyanins, isoquercetrin, quercetin, quercetrin, procyanidins, apigenin, luteolin, and rutin, respectively. Due to the presence of phytochemicals, date palm causes significant reduction in low density lipoproteins, very low density lipoproteins cholesterol and enhancement in high density lipoprotein They also increase the antioxidant enzymes such as paraoxonase 1 arylesterase, glutathione peroxidase and superoxide dismutase in serum that block free radicals production. Phytochemicals from date fruit lowered the creatine kinase-MB, lactate dehydrogenase activities and levels of cardiac malondialdehyde. Moreover, phytosterols inhibit cholesterol absorption in small intestine by preventing the attachment of cholesterol with micellar bindings. Besides, these bioactive compounds also inhibit the bio synthesis of cholesterol by restricting gene expression of HMG-CoA reductase enzyme. The current review highlight the preventive role of phytochemicals from date fruit against cardiovascular abnormalities via controlling lipid profile, preventing free radicals production, maintaining sodium metabolism and improving cardiac muscles contraction.
Cardio protective effects of dates
Ahmed S, Alam Khan R, Jamil S. 2016. Anti hyperlipidemic and hepatoprotective effects of native date fruit variety” Aseel”(Phoenix dactylifera). Pakistan journal of pharmaceutical sciences 29(6), 1945-1950.
Al-Dhabi NA, Arasu MV, Park CH, Park SU. 2015. An up-to-date review of rutin and its biological and pharmacological activities. EXCLI journal 14, 59-63.
Al Harthi SS, Mavazhe A, Al Mahroqi H, Khan SA. 2015. Quantification of phenolic compounds, evaluation of physicochemical properties and antioxidant activity of four date (Phoenix dactylifera L.) varieties of Oman. Journal of Taibah University Medical Sciences 10(3), 346-352.
Al-Farsi MA, Lee CY. 2008. Nutritional and functional properties of dates: a review. Critical reviews in food science and nutrition 48(10), 877-887.
Aliga MS, Baliga BRV, Kandathil SM, Bhat HP, Vayalil PK. 2011. A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.). Food research international 44(7), 1812-1822.
Al-Farsi M, Alasalvar C, Morris A, Baron M, Shahidi F. 2005. Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of
three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. Journal of agricultural and food chemistry 53(19), 7592-9.
Alhaider IA, Mohamed ME, Ahmed KKM, Kumar AH. 2017. Date palm (Phoenix dactylifera) fruits as a potential cardioprotective agent: The role of circulating progenitor cells. Frontiers in pharmacology 592(8), 1-11.
Ali A, Al-Kindi YS, Al-Said F. 2009. Chemical composition and glycemic index of three varieties of Omani dates. International journal of food sciences and nutrition 60(4), 51-62.
Al-Jasass FM, Siddiq M, Sogi DS. 2015. Antioxidants activity and color evaluation of date fruit of selected cultivars commercially available in the United States. Advances in Chemistry 1-5.
Al-Mamary M, Al-Habori M, Al-Zubairi AS. 2014. The in vitro antioxidant activity of different types of palm dates (Phoenix dactylifera) syrups. Arabian Journal of Chemistry 7(6), 964-971.
Alsaif MA, Khan LK, Alhamdan AA, Alorf SM, Harfi SH, Al-Othman AM, Arif Z. 2007. Effect of dates and gahwa (Arabian Coffee) supplementation on lipids in hypercholesterolemic hamsters. International Journal of Pharmacology 3(2), 123-129.
Al-Yahya M, Raish M, AlSaid MS, AhmadA, Mothana RA, Al-Sohaibani, Rafatullah S. 2016. ‘Ajwa’dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model. Phytomedicine, 23(11), 1240-1248.
Asadi-Shekaari M, Rajabalian S, Gholamhoseinian A, Ganjooei NA, Hoseini R, Mahmoodi M. 2008. Protective effect of aqueous extract of date fruit against in vitro h 2 o 2-induced cell damages. Current Topics in Nutraceutical Research 6(2), 99-103.
Ambali S, Akandi D, Igbokwe N, Shittu M, Kawu M, Ayo J. 2007. Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C. J Toxicol Science 32(2), 111–120.
Batta AK, Xu G, Honda A, Miyazaki T, Salen G. 2006. Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat. Metabolism 55(3), 292-299.
Bakr Abdu S. 2011. The protective role of Ajwa date against the Hepatotoxicity induced by Ochratoxin. Egyptian Journal of Natural Toxins 1(8), 1-15.
Bonner MY, Arbiser JL. 2014. The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer. Future medicinal chemistry 6(12), 1413-1422.
Borochov-Neori H, Judeinstein S, Greenberg, A, Volkova N, Rosenblat M, Aviram M. 2013. Date (Phoenix dactylifera L.) fruit soluble phenolics composition and anti-atherogenic properties in nine Israeli varieties. Journal of agricultural and food chemistry 61(18), 4278-4286.
Boudries H, Kefalas P, Hornero-Méndez D. 2007. Carotenoid composition of Algerian date varieties (Phoenix dactylifera) at different edible maturation stages. Food Chemistry, 101(4), 1372-1377. https://doi.org/10.1016/j.foodchem.2006.03.043
Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Zimmermann BF. 2015. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: a randomised double-blinded placebo-controlled cross-over trial. British Journal of Nutrition 114(8), 1263-1277.
Cassidy A, O’Reilly ÉJ, Kay C, Sampson L, Franz M, Forman JP, Rimm EB. 2010. Habitual intake of flavonoid subclasses and incident hypertension in adults. The American journal of clinical nutrition 93(2), 338-347.
Chao CT, Krueger RR. 2007. The date palm (Phoenix dactylifera L.): overview of biology, uses, and cultivation. HortScience 42(5), 1077-1082.
Chaira N, Smaali MI, Martinez-Tomé M, Mrabet A, Murcia MA, Ferchichi A. 2009. Simple phenolic composition, flavonoid contents and antioxidant capac-ities in water–methanol extracts of Tunisian common date cultivars (PhoenixdactyliferaL.). Internaltional Journal of Food Sciences and Nutrition 60(7), 316−329.
Chen YF, Shibu MA, Fan MJ, Chen MC, Viswanadha VP, Lin YL, Huang CY. 2016. Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis. The Journal of nutritional biochemistry 31, 98-105.
Dimitrios B. 2006. Sources of natural phenolic antioxidants. Trends in Food Science & Technology 17(9), 505-512.
Diwan V, Brown L, Gobe GC. 2017. The flavonoid
rutin improves kidney and heart structure and function in an adenine-induced rat model of chronic kidney disease. Journal of functional foods 33, 85-93.
Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D, Hollman PC. 2015. Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial. The American journal of clinical nutrition 101(5), 914-921.
De Paula TP, Steemburgo T, de Almeida JC, Dall’Alba V, Gross JL, de Azevedo MJ. 2012. The role of Dietary Approaches to Stop Hypertension (DASH) diet food groups in blood pressure in type 2 diabetes. British Journal of Nutrition 108(1), 155-162.
El Fouhil AF, Ahmed AM, Atteya M, Mohamed RA, Moustafa AS, Darwish HH. 2013. An extract from date seeds stimulates endogenous insulin secretion in streptozotocin-induced type I diabetic rats. Functional Foods in Health and Disease 3(11), 441-446.
Eggersdorfer M, Wyss A. 2018. Carotenoids in human nutrition and health. Archives of biochemistry and biophysics 652, 18-26.
Fiedor J, Burda K. 2014. Potential role of carotenoids as antioxidants in human health and disease. Nutrients 6(2), 466-488.
Forman HJ, Davies KJ, Ursini F. 2014. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radical Biology and Medicine 66, 24-35.
Ganeshpurkar A, Saluja AK. 2017. The pharmacological potential of rutin. Saudi pharmaceutical journal 25(2), 149-164.
Gylling H, Plat J, Turley S, Ginsberg HN, Ellegård L, Jessup W, Silbernagel G. 2014. Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis 232(2), 346-360.
Hamad I, AbdElgawad H, Al Jaouni S, Zinta G, Asard H, Hassan S, Selim S. 2015. Metabolic analysis of various date palm fruit (Phoenix dactylifera L.) cultivars from Saudi Arabia to assess their nutritional quality. Molecules 20(8), 13620-13641. https://doi.org/10.3390/molecules200813620.
Hassan W, Noreen H, Rehman S, Gul S, Amjad Kamal M, Paul Kamdem BT, da Rocha J. 2017. Oxidative stress and antioxidant potential of one hundred medicinal plants. Current topics in medicinal chemistry 17(12), 1336-1370.
Hasson SS, Al-Shaqsi MS, Albusaidi JZ, Al-Balushi MS, Hakkim FL, Aleemallah GM, Al-Jabri AA. 2018. Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing. Asian Pacific Journal of Tropical Biomedicine 8(7), 371.
Hosseinzadeh H, Nassiri-Asl M. 2014. Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid. Journal of endocrinological investigation 37(9), 783-788.
Huseen Bukht, Haroon Jamshaid Qazi, Zeenat Islam, Sana Farooq, Bahisht Rizwan, Shahid Bashir, Muhammad Zia Shahid, Muzzamal Hussain, Tabussam Tufail. 2020. Assessment of nutritional status and dietary patterns of orphans residing in different orphanages of Lahore, Pakistan. International Journal of Biosciences 16(4), 19-33.
Ahmed MJ. 2016. Preparation of activated carbons from date (Phoenix dactylifera L.) palm stones and application for wastewater treatments. Process safety and environmental protection 102, 168-182.
Ismail B, Haffar I, Baalbaki R, Henry J. 2008. Physico-chemical characteristics and sensory quality of two date varieties under commercial and industrial storage conditions. LWT-Food Science and Technology 41(5), 896-904.
John S, Sorokin AV, Thompson PD. 2007. Phytosterols and vascular disease. Current opinion in lipidology 18(1), 35-40.
Jung UJ, Lee MK, Park YB, Jeon SM, Choi M. S. 2006. Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. Journal of pharmacology and experimental therapeutics 318(2), 476-483.
Jung CH, Cho I, Ahn J, Jeon TI, Ha TY. 2013. Quercetin reduces high‐fat diet‐induced fat accumulation in the liver by regulating lipid metabolism genes. Phytotherapy Research 27(1), 139-143.
He F, Zuo L. 2015. Redox roles of reactive oxygen species in cardiovascular diseases. International journal of molecular sciences 16(11), 27770-27780.
Kim SJ, Yadav D, Park HJ, Kim JR, Cho KH. 2018. Long-term consumption of Cuban policosanol lowers central and brachial blood pressure and improves lipid profile with enhancement of lipoprotein properties in healthy Korean participants.
Frontiers in physiology 9(412), 1-11.
Kehili HE, Zerizer S, Beladjila KA, Kabouche Z. 2016. Anti-inflammatory effect of Algerian date fruit (Phoenix dactylifera). Food and agricultural immunology 27(6), 820-829.
Khan M, Siddiqui N. 2017. Role of Ajwa in the treatment and prevention of ischaemic heart disease. JPMA. The Journal of the Pakistan Medical Association 67(12), 1954-1954.
Khan SA, Al Kiyumi AR, Al Sheidi MS, Al Khusaibi TS, Al Shehhi NM, Alam T. 2016. In vitro inhibitory effects on α-glucosidase and α-amylase level and antioxidant potential of seeds of Phoenix dactylifera L. Asian Pacific Journal of Tropical Biomedicine 6(4), 322-329.
Kooshki A, Hoseini BL. 2014. Phytochemicals and hypertension. Shiraz E-Medical Journal, 15(1). https://dx.doi.org/10.17795/semj19738.
Mangge H, Becker K, Fuchs D, Gostner JM. 2014. Antioxidants, inflammation and cardiovascular disease. World journal of cardiology, 6(6), 462-477.
Li Y, Yao J, Han C, Yang J, Chaudhry M, Wang S Yin Y. 2016. Quercetin, inflammation and immunity. Nutrients 8(3), 167.
Liolios CC, Sotiroudis GT, Chinou I. 2008. Fatty acids, sterols, phenols and antioxidant activity of Phoenix theophrasti fruits growing in Crete, Greece. Plant Foods for Human Nutrition 64, 52−61.
Mehraban F, Jafari M. Toori MA, Sadeghi H,
Joodi B, Mostafazade M, Sadeghi H. 2014. Effects of date palm pollen (Phoenix dactylifera L.) and Astragalus ovinus on sperm parameters and sex hormones in adult male rats. Iranian journal of reproductive medicine 12(10), 705-712.
Mistrello J, Sirisena SD, Ghavami A, Marshall RJ, Krishnamoorthy S. 2014. Determination of the antioxidant capacity, total phenolic and flavonoid contents of seeds from three commercial varieties of culinary dates. International Journal of Food Studies 3(1), 34-44.
Mubarak S, Hamid S, Farrag A, Samir N, Hussein J. 2018. Cardioprotective Effect of Date Palm Against Doxorubicin-Induced Cardiotoxicity. Asian Journal of Pharmaceutical and Clinical Research 11(7), 141-146.
Mushtaq Z, Kausar S, Kousar N, Chiragh S. 2017. Effect of ajwa date seed on lipid profile of diet induced hyperlipidemic rabbits. Khyber Medical University Journal 9(3), 135-139.
Nadeem M, Rehman SU, Anjum FM, Bhatti IA. 2011. Textural profile analysis and phenolic content of some date palm varieties. Journal of agricultural research 49(4), 525-39.
Naseem S, Khattak UK, Ghazanfar H, Irfan A. 2016. Prevalence of non-communicable diseases and their risk factors at a semi-urban community, Pakistan. Pan African Medical Journal 23(1), 1-8.
Niazi S, Khan IM, Pasha I, Rasheed S, Ahmad S, Shoaib M. 2017. Date Palm: Composition, Health Claim and Food Applications. Int J Public Health and
Health Systems 2(1), 9-17.
Pagliaro B, Santolamazza C, Simonelli F, Rubattu S. 2015. Phytochemical compounds and protection from cardiovascular diseases: a state of the art. BioMed research international, 1-18.
Pushpa I, Jayachitra J. 2015. Hypolipidemic and antioxidant activity of phoenix dactylifera L in albino wistar rats. World Journal of Pharmacy and Pharmaceutical Sciences 4, 790-798.
Pojer E, Mattivi F, Johnson D, Stockley CS. 2013. The case for anthocyanin consumption to promote human health: a review. Comprehensive Reviews in Food Science and Food Safety 12(5), 483-508.
Quiñones M, Miguel M, Aleixandre A. 2013. Beneficial effects of polyphenols on cardiovascular disease. Pharmacological research 68(1), 125-131.
Ras RT, Fuchs D, Koppenol WP, Garczarek U, Greyling A, Keicher C, Trautwein EA. 2015. The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant Sterols (INVEST) study. The American journal of clinical nutrition 101(4), 733-741.
Ried K, Fakler P. 2011. Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials. Maturitas, 68(4), 299-310. https://doi.org/10.1016/j.maturitas.2010.11.018.
Rock W, Rosenblat M, Borochov-Neori H, Volkova N, Judeinstein S, Elias M, Aviram M. 2009. Effects of date (Phoenix dactylifera L., Medjool or Hallawi Variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: a pilot study. Journal of agricultural and food chemistry 57(17), 8010-8017.
Rosenblat M, Volkova N, Borochov-Neori H, Judeinstein S, Aviram M. 2015. Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination. Food & function 6(5), 1496-1509.
Salah EBSB, El Arem A, Louedi M, Saoudi M, Elfeki A, Zakhama Achour L. 2012. Antioxidant-rich date palm fruit extract inhibits oxidative stress and nephrotoxicity induced by dimethoate in rat. Journal of physiology and biochemistry 68(1), 47-58.
Shan Y, Zhao, R, Geng W, Lin N, Wang X, Du X, Wang S. 2010. Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage. Cardiovascular toxicology 10(2), 139-145.
Sureka M, Sumathi R, Kanagavalli U. 2016. A Comprehensive Review on Cardiotoxic Drugs and Cardioprotective Medicinal Plants. International Journal of Pharma Research & Review 5(10), 21-34.
Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. 2016. Epidemiology of coronary heart disease and acute coronary syndrome. Annals of translational medicine 4(13), 1-12.
Sánchez‐Maldonado AF, Schieber A, Gänzle MG. 2011. Structure–function relationships of the antibacterial activity of phenolic acids and their metabolism by lactic acid bacteria. Journal of applied microbiology 111(5), 1176-1184.
Sulieman AM, Abd Elhafise I, Abdelrahim A. 2012. Comparative study on five Sudanese date (Phoenix dactylifera L.) fruit cultivars 3, 1245-1251.
Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B. 2007. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). Journal of ethnopharmacology 110(1), 105-117.
Takaeidi MR, Jahangiri A, Khodayar MJ, Siahpoosh A, Yaghooti H, Rezaei S, Mansourzadeh Z. 2014. The effect of date seed (Phoenix dactylifera) extract on paraoxonase and arylesterase activities in hypercholesterolemic rats. Jundishapur journal of natural pharmaceutical products 9(1), 30-34.
Trabzuni DM, Ahmed SEB, Abu-Tarboush H. M. 2014. Chemical composition, minerals and antioxidants of the heart of Date Palm from three Saudi cultivars. Food and Nutrition Sciences 5(14), 1379-1386.
Upadhyay S, Dixit M. 2015. Role of polyphenols and other phytochemicals on molecular signaling. Oxidative Medicine and Cellular Longevity, 1-15.
Vayalil PK. 2012. Date fruits (Phoenix dactylifera Linn): an emerging medicinal food. Critical reviews in food science and nutrition 52(3), 249-271.
Wolak T, Paran E. 2013. Can carotenoids attenuate vascular aging? Vascular pharmacology 59(3-4), 63-66.
Yamagata K, Tagami M, Yamori Y. 2015. Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. Nutrition 31(1), 28-
Yasin B, El-Fawal H, Mousa S. 2015. Date (Phoenix dactylifera) Polyphenolics and other bioactive compounds: a traditional Islamic Remedy’s potential in prevention of cell damage, cancer therapeutics and beyond. International journal of molecular sciences 16(12), 30075-30090.
Zaid A, de Wet PF, Djerbi M, Oihabi A. 2002. In Date palm cultivation, Diseases and pests of date palm, ed Zaid A. Food and Agriculture Organization Plant Production and Protection Paper (156), 227-281.
Zahoor T, Saeed F, Ahmad A. 2011. Anti-nutritional factors in some date palm (Phoenix dactylifera L.) varieties grown in Pakistan. Internet Journal of Food Safety, 13, 386-390.Corpus ID: 130380283.
Zhang CR, Aldosari SA, Vidyasagar PS, Nair KM, Nair MG. 2013. Antioxidant and anti-inflammatory assays confirm bioactive compounds in Ajwa date fruit. Journal of agricultural and food chemistry 61(24), 5834-5840.
Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu D. P, Li HB. 2015. Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules 20(12), 21138-21156.
Zhu Y, Huang X, Zhang Y, Wang Y, Liu Y, Sun R, Xia M. 2014. Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia. The Journal of Clinical Endocrinology & Metabolism 99(2), 561-569.
Zorov DB, Juhaszova M, Sollott SJ. 2014. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiological reviews 94(3), 909-950.
Cardio protective effects of dates.
Int. J. Biosci. 16(5), 110-123, May 2020.
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