Dendrimers: A potential novel drug carrier
By: Aysha Aslam, Rushda Bedar
Key Words: Dendrimers, Monodispersity, Nanocarriers, Novel targeted drug delivery, PEGylation.
Int. J. Biosci. 18(1), 68-81, January 2021.
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Dendrimers- a novel synthetic polymeric system, comes with unique physicochemical properties due to their exclusive three-dimensional structure. Thus, features like distinct shape, size, monodispersity and the molecular weight is attained. Moreover, it presents compatibility with drug active moieties along with bioactive molecules including heparin, DNA and polyanions, to name a few. The recognition abilities and nanoscopic size make it a remarkable tool for self-assembly and coordination. In addition to this, the internal voids of the dendritic configuration allow the incorporation of hydrophilic and phobic drugs. Yet the end groups are catered for combining the bioactive constituents and antibodies, enabling better reactivity, solubility and miscibility. Currently, dendrimers are a point of interest for the exploration of new routes and to serve as nanocarriers. However, the cationic charge and toxicity are neutralized via PEGylation of dendrimers still keeping its carrier properties intact. The undertaken review comprises numerous properties and structural characteristics of dendrimers and their applications as a potential novel delivery system.
Dendrimers: A potential novel drug carrier
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Dendrimers: A potential novel drug carrier.
Int. J. Biosci. 18(1), 68-81, January 2021.
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Natural Sciences (INNSPUB)