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Dihydromyricetin, a multi-perspective medicinal entity

By: Wencong Liu, Sadia Khatoon, Yinan Zheng, Xin-xin She, Ming-tong Gao, Zahid hussain shah, Xinglong Liu, Lulu Zeng, XueyanChen, Chuan-bo Ding

Key Words: DHM, Anti-cancer, Anti-oxidant, ROS.

Int. J. Biosci. 14(5), 378-388, May 2019.

DOI: http://dx.doi.org/10.12692/ijb/14.5.378-388

Certification: ijb 2019 0043 [Generate Certificate]

Abstract

Dihydromyricetin called flavonoid also known as ampelopsin and extract from Ampelopsis grossedentata, it found in various species of plants such as Japanese Raisin Tree, the Himalayan Cedar Tree, the African Blackwood but it mostly obtained from Ampelopsis grossedentata which mostly occurs in the warm climate of china. Dihydromyricetin exhibit a lot of biological activities with minimum side effects,it shows anti-cancer, apoptotic, anti-inflammatory and anti-oxidant activity, dihydromyricetin play an important role in anti-inflammation after binding to a novel binding site IKK-Cys46,it may stroll the reactive oxygen species and shows oxidative stress mediating activity and also selectively diminish cancer cell without effecting normal cells by this way it have anti-tumour activity. DHM cause the induction of apoptosis by interfering with many signaling pathways such as ERK1/2 and p38 MAPK, Bcl2/Bax, DR4 and DR5, increase activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH)can cause the elimination of EtOH and by this way DHM amend the liver injuries due to alcohol consumption and so act as a novel anti-alcohol agent. Previous researches makes a lot advances in clinical applications of DHM but this is not enough further researches also need to do. Lower and hight levels of dihydromyricetin may limits its potential applications, in this review we will discuss the different biological activities of dihydromyricetin and how it works as a multi-perspective medicinal Entity.

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Dihydromyricetin, a multi-perspective medicinal entity

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Wencong Liu, Sadia Khatoon, Yinan Zheng, Xin-xin She, Ming-tong Gao, Zahid hussain shah, Xinglong Liu, Lulu Zeng, XueyanChen, Chuan-bo Ding.
Dihydromyricetin, a multi-perspective medicinal entity.
Int. J. Biosci. 14(5), 378-388, May 2019.
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