Drug discovery and development: current practices and future
Paper Details
Drug discovery and development: current practices and future
Abstract
Drug discovery and development encompasses the entire procedure of recognizing a drug from its discovery phase until its launch to market. The field of drug design discovery and development is a multifaceted, high-risk, high octane, and probably highly illuminating and rewarding venture. The current study aimed to highlight the current practices and future of drug discovery and development. Various databases, including Scopus, Web of Science, and PubMed, were utilized to search the literature. Natural products are still the first choice of starting material for drug discovery despite recent advances, the rise, and the integral role of combinatorial chemistry in the lead discovery process. Recent analytical and computer technology developments have opened new avenues for processing complex natural products and using their structures to generate new and innovative drugs. In recent times, it has promised biotechnology as a forerunner in the path to the insurrection of human lives. Various products include novel vaccines, diagnostic devices, and new therapeutic strategies, are the achievements of biotechnology in the biomedical domain. Drug discovery is a multidimensional question. It must be evaluated during drug candidates’ selection by several parameters such as safety, pharmacokinetics, and efficacy. For a drug entity to pass different stages of its development has to go through significant drawbacks and pitfalls.
Alagarsamy V. 2013. Drug desig. Textbook of Medicinal Chemistry Elsevier Health Sciences 1, 55-96.
Ashiq K, Bajwa MA, Tanveer S, Qayyum M, Ashiq S, Khokhar R, Abid FA. 2021. comprehensive review on gout: The epidemiological trends, pathophysiology, clinical presentation, diagnosis and treatment. JPMA. The Journal of the Pakistan Medical Association 71(4), 1234-8. https://doi.org/10.47391/jpma.313
Ashiq K, Tanveer S, Qayyum M, Bajwa M, Ashiq S, Shahzad A, Tariq Z, Faisal M, Ahmad N, Arsahd A, Sattar R. 2019. Common herbal plants and their role in control of obesity. International Journal of Biosciences 15(4), 23-32. http://dx.doi.org/10.12692/ijb/15.4.23-32
Ashiq S, Ashiq K. In-silico analysis of PON1, PON2 and PON3 genes role in coronary artery disease. 2020. International Journal of Computational Biology and Drug Design 13(4), 415-23. https://doi.org/10.1504/IJCBDD.2020.111057
Balunas MJ, Kinghorn AD. 2005. Drug discovery from medicinal plants. Life Sciences 78(5), 431-41. https://doi.org/10.1016/j.lfs.2005.09.012
Bhikha R. 2017. Tibb: a science of medicine the art of care. Asian Journal of Science and Technology 8 (3), 4438-4442.
Bhikha R, Glynn J. The role of tibb in integrative medicine for diseases of lifestyle. Bangladesh Journal of Medical Science 16(1), 13-20. https://doi.org/10.3329/bjms.v16i1.31126
Corson TW, Crews CM. 2007. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130(5), 769-774. https://doi.org/10.1016/j.cell.2007.08.021
Csermely P, Agoston V, Pongor S. 2005. The efficiency of multi-target drugs: the network approach might help drug design. Trends in Pharmacological Sciences 26(4), 178-182. https://doi.org/10.1016/j.tips.2005.02.007
Deshmane J, Hajare S, Patil H, Chaudhari P, Ghode SP, Chatur MV. 2020. Marine pharmaceuticals: a review. International Journal of Pharmaceutical Sciences and Medicine 5(5), 1-13.
Dickson M, Gagnon JP. 2009. The cost of new drug discovery and development. Discovery Medicine 4(22), 172-179.
Duelen R, Corvelyn M, Tortorella I, Leonardi L, Chai YC, Sampaolesi M. 2019. Medicinal Biotechnology for Disease Modeling, Clinical Therapy, and Drug Discovery and Development. Introduction to Biotech Entrepreneurship: From Idea to Business 89-128. https://doi.org/10.1007/978-3-030-22141-6_5
Grimme S, Schreiner PR. 2018. Computational chemistry: the fate of current methods and future challenges. Angewandte Chemie International Edition 57(16), 4170-4176. https://doi.org/10.1002/anie.201709943
Harvey AL. 2008. Natural products in drug discovery. Drug Discovery Today 13(19-20), 894-901. https://doi.org/10.1016/j.drudis.2008.07.004
Hinkelbein J, Neuhaus C, Böhm L, Kalina S, Braunecker S. 2017. In-flight medical emergencies during airline operations: a survey of physicians on the incidence, nature, and available medical equipment. Open access Emergency Medicine: OAEM 9, 31. https://dx.doi.org/10.2147%2FOAEM.S129250
Jossen V, Van den Bos C, Eibl R, Eibl D. 2018. Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges. Applied Microbiology and Biotechnology 102(9), 3981-3994. https://doi.org/10.1007/s00253-018-8912-x
Kanwal A, Abida L, Sana A, Ahlam S. 2018. A systematic review on the prevalence, pathophysiology, diagnosis, management and treatment of gout (2007-2018). GSC Biological and Pharmaceutical Sciences 5(1), 50-55. https://doi.org/10.30574/gscbps.2018.5.1.0077
Kelm JM, Lal-Nag M, Sittampalam GS, Ferrer M. 2019. Translational in vitro research: Integrating 3D drug discovery and development processes into the drug development pipeline. Drug Discovery Today 24(1), 26-30. https://doi.org/10.1016/j.drudis.2018.07.007
Kiuru P, DʼAuria MV, Muller CD, Tammela P, Vuorela H, Yli-Kauhaluoma J. 2014. Exploring marine resources for bioactive compounds. Planta Medica 80(14), 1234-1246. https://doi.org/10.1055/s-0034-1383001
Kong DX, Li XJ, Zhang HY. 2009. Where is the hope for drug discovery? Let history tell the future. Drug Discovery Today 14(3-4), 115-119. https://doi.org/10.1016/j.drudis.2008.07.002
Latif A, Ashiq K, Ashiq S, Ali E, Anwer I, Qamar S. 2020. Phytochemical analysis and in vitro investigation of anti-inflammatory and xanthine oxidase inhibition potential of root extracts of Bryophyllum pinnatum. Journal of Animal and Plant Sciences 30(1), 219-228.
Leelananda SP, Lindert, S. 2016. Computational methods in drug discovery. Beilstein Journal of Organic Chemistry 12(1), 2694-2718. https://doi.org/10.3762/bjoc.12.267
Lukomska B, Stanaszek L, Zuba-Surma E, Legosz P, Sarzynska S, Drela K. 2019. Challenges and controversies in human mesenchymal stem cell therapy. Stem Cells International 2019, 9628536. https://doi.org/10.1155/2019/9628536
Moderator, Bahinski A, Participants:, Horland R, Huh D, Mummery C, Tagle DA, MacGill T. 2015. The promise and potential of “organs-on-chips” as preclinical models. Applied In Vitro Toxicology 1(4), 235-242. https://doi.org/10.1089/aivt.2015.29002.rtl
Mohs RC, Greig NH. 2017. Drug discovery and development: Role of basic biological research. Alzheimer’s & Dementia: Translational Research and Clinical Interventions, 3(4), 651-657. https://doi.org/10.1016/j.trci.2017.10.005
Patil SB, Patil MS, Chittam KP, Wagh RD. 2014. A review on Ayurveda and siddha: indian systems of medicine. Pharma Science Monitor 5(2).
Patwardhan B. 2005. Ethnopharmacology and drug discovery. Journal of Ethnopharmacology 100, 50-52. https://doi.org/10.1016/j.jep.2005.06.006
Qayyum M, Ashiq K, Tanveer S, Bajwa MA, Shah-Rukh A, Jahangir N. 2020. Review on phytochemical evaluation and extraction of Nigella sativa (Kalongi) with pharmacological and traditional applications. International Journal of Biosciences 16(3), 231-241. http://dx.doi.org/10.12692/ijb/16.3.231-241
Raju TN. 1999. The nobel chronicles. The Lancet, 353(9168), 1981.
RavichandranS, Verma G. 2021. Advanced biotechnology-based therapeutics. Translational Biotechnology 2021 53-77. https://doi.org/10.1016/B978-0-12-821972-0.00009-5
Reddy AS, Zhang S. 2013. Polypharmacology: drug discovery for the future. Expert Review of Clinical Pharmacology 6(1), 41-47. https://doi.org/10.1586/ecp.12.74
Sams-Dodd F. 2005. Target-based drug discovery: is something wrong? Drug Discovery Today 10(2), 139-147. https://doi.org/10.1016/S1359-6446(04)03316-1
Sannigrahi N. 2014. Traditional knowledge of medicinal plants & self-help group: a key to sustainable development. Journal of Medicinal Plants 2(3), 14-24.
Sharma AK. 2020. Genetically engineered microbes for sustainable therapies New and Future Developments in Microbial Biotechnology and Bioengineering 2020, 125-145. https://doi.org/10.1016/B978-0-12-8205280.00009-0
Shirbeigi L, Zarei A, Naghizadeh A, Vaghasloo MA. 2017. The concept of temperaments in traditional Persian medicine. Traditional and Integrative Medicine 143-156.
Strovel J, Sittampalam S, Coussens NP, Hughes M, Inglese J, Kurtz A, Andalibi A, Patton L, Austin C, Baltezor M, Beckloff M. 2016. Early drug discovery and development guidelines: for academic researchers, collaborators, and start-up companies. Assay Guidance Manual [Internet].
Tanveer S, Latif A, Ashiq K, Qayyum M, Bajwa MA. 2019. A comprehensive review on pharmacological and phytochemical potential of Cassia Fistula Linn: A Magical Herb. International Journal of Biology, Pharmacy and Allied Sciences 8(6), 1134-1157. https://doi.org/10.31032/IJBPAS/2019/8.6.4734
Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, Dzobo K. 2018. Natural products for drug discovery in the 21st century: innovations for novel drug discovery. International Journal of Molecular Sciences 19(6), 1578. https://doi.org/10.3390/ijms19061578
Van der Greef J, McBurney RN. 2005. Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nature Reviews Drug Discovery 4(12), 961-967. https://doi.org/10.1038/nrd1904
Velasquez JR. 2021. Neurophysiology of Space Medicine: A Literature Review. MEDI 9331 Scholarly Activities Clinical Years. 45.
Zimmermann GR, Lehar J, Keith CT. 2007. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discovery Today 12(1-2), 34-42. https://doi.org/10.1016/j.drudis.2006.11.008
Kanwal Ashiq, Mehwish Qayyum, Rashida Parveen, Mayyda Asif Bajwa, Shafiq Ali Shah, Rana Mohsin Ismail, Sana Ashiq (2021), Drug discovery and development: current practices and future; IJB, V19, N3, September, P31-39
https://innspub.net/drug-discovery-and-development-current-practices-and-future/
Copyright © 2021
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0