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Effects of essential amino acid “Tryptophan” in post burn skin wound healing

By: Alia Sadiq, Muhammad Qasim Hayat, Gulshan Ara Trali, Ambreen Javed

Key Words: Wound healing, Tryptophan, BrdU, CD31, Angiogenesis, Proliferation.

Int. J. Biosci. 12(3), 147-153, March 2018.

DOI: http://dx.doi.org/10.12692/ijb/12.3.147-153

Certification: ijb 2018 0002 [Generate Certificate]

Abstract

Skin wound healing is a complex process and regulated by various growth factors and vital compounds. This study was carried out to assess the role of tryptophan in post burn skin wound healing by using scald burn model in Balb C mice. We employed tryptophan as topical cream formulation in post burn wound model. Post-wounding analysis showed improved healing represented by smaller wound length, wound area and increased wound cellularity in tryptophan treated group as compared to the control. Comparatively, enhanced expression of CD31 also observed in tryptophan treated group, indicated improved angiogenesis. Immunohistochemical staining showed more number of BrdU+ve proliferating cells in the wound center, revealed that proliferation rate was significantly high in the treated group. It is suggesting that wounds treated with the tryptophan conceded the proliferation phase faster. This study revealed that tryptophan (an essential amino acid) has potential to improve the burn skin wound healing. Therefore, tryptophan-based therapeutics can be a potential candidate to investigate further about their mechanism of action for improved wound healing process.

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Effects of essential amino acid “Tryptophan” in post burn skin wound healing

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Alia Sadiq, Muhammad Qasim Hayat, Gulshan Ara Trali, Ambreen Javed.
Effects of essential amino acid “Tryptophan” in post burn skin wound healing.
Int. J. Biosci. 12(3), 147-153, March 2018.
https://innspub.net/ijb/effects-essential-amino-acid-tryptophan-post-burn-skin-wound-healing/
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