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Gallic acid mitigates apoptotic cell death induced by the anticancer drug tamoxifen in female rats

By: Eman M. Saleh, Germine M. Hamdy, Dina M. Seoudi

Key Words: Tamoxifen, Gallic, E-cadherin, Caspase-3, Na+/K+ ATPase.

Int. J. Biosci. 12(3), 70-86, March 2018.

DOI: http://dx.doi.org/10.12692/ijb/12.3.70-86

Certification: ijb 2018 0002 [Generate Certificate]

Abstract

Tamoxifen (TAM),the anti-estrogenic agentwas used for advanced breast cancer management. Despite its benefits, a number of clinical reports have demonstrated many side effects. Therefore, this study was designed to assess the possible hepatoprotective effects of Gallic acid (GA) against TAM-induced abnormalities in female rats. Fifty adult female Sprague dawleyrats were divided into 5 groups. Group I: normal control, Group II: TAM group, Group III: GA group, Group IV:prophylactic group of GA, Group V:prophylactic group of silymarin. Blood and liver tissues were collected for biochemical, and histopathological studies. Group II; rats receiving TAM, showed significant increases in serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, E-cadherin, and Caspase-3 and decreases in albumin and Na+/K+ ATPase activity. The Prophylactic group of GA; group IV, significantly reduced the elevated levels of the previously mentioned biochemical markers, as well as increased the levels of serum albumin and liver Na+/K+ ATPase. Histopathology of liver and spleen also confirmed the protective effective of GA. The results confirm that administration of GA showed better results than that of the standard drug silymarin. Therefore, GA assumes to be a promising hepatoprotective agent that ameliorates the side effects induced by TAM therapy.

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Gallic acid mitigates apoptotic cell death induced by the anticancer drug tamoxifen in female rats

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Eman M. Saleh, Germine M. Hamdy, Dina M. Seoudi.
Gallic acid mitigates apoptotic cell death induced by the anticancer drug tamoxifen in female rats.
Int. J. Biosci. 12(3), 70-86, March 2018.
https://innspub.net/ijb/gallic-acid-mitigates-apoptotic-cell-death-induced-anticancer-drug-tamoxifen-female-rats/
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