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Identification of Biomarker Signatures and Candidate Drugs in Non-Small Cell Lung Cancer

By: Md. Parvez Mosharaf, Amina Rownaq, S.M. Shahinul Islam, Md. Nurul Haque Mollah

Key Words: Non-small cell lung cancer, Molecular signature, Molecular pathway, differentially expressed genes, Protein-protein interaction.

Int. J. Biosci. 16(1), 107-119, January 2020.

DOI: http://dx.doi.org/10.12692/ijb/16.1.107-119

Certification: ijb 2020 0307 [Generate Certificate]

Abstract

Lung cancer is the most important health risk for human in worldwide. Non-small cell lung cancer (NSCLC) is the most common cause of premature death from malignant disease. The aim of the study was to determine the pathways and expression profile of the genes to discover molecular signature at RNA and protein levels which could serve as potential drug targets for therapeutics innovation and the identification of novel targets. Eight proteins, six TFs and seven miRNAs came into prominence as potential drug targets. The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq. Risk discrimination performance of the reporter biomolecules NPR3, JUN, PPARG, TP53, CKMT1A, SP3 and TFAP2A were also evaluated. Total 213 drugs and 7 proteins was found for non-small cell lung cancer through dgidb. Among these identified drugs seven drugs such as- Gemcitabine, Carboplatin, paclitaxel, Docetaxel, Crizotinib, Bevacizumab and Gemcitabine is used for NSCLC which is approved by National Cancer Institute. The molecular signatures and repurposed drugs presented here permit further attention for experimental studies which are offer significant potential as biomarkers and candidate therapeutics for precision medicine approaches to clinical management of NSCLC.

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Identification of Biomarker Signatures and Candidate Drugs in Non-Small Cell Lung Cancer

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Md. Parvez Mosharaf, Amina Rownaq, S.M. Shahinul Islam, Md. Nurul Haque Mollah.
Identification of Biomarker Signatures and Candidate Drugs in Non-Small Cell Lung Cancer.
Int. J. Biosci. 16(1), 107-119, January 2020.
https://innspub.net/ijb/identification-biomarker-signatures-candidate-drugs-non-small-cell-lung-cancer/
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