Identifying differential expression of human genes under physical, chemical and biotic stresses

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Research Paper 01/06/2021
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Identifying differential expression of human genes under physical, chemical and biotic stresses

Saba Afzal, Muhammad Younas Khan Barozai, Shafia Muzaffar, Farrukh Bashir, Farida Behlil, Uzma Jabeen, Ayesha Mushtaq, Zil-e-Huma, Bibi Sherino, Syed Shujat Ali Zaidi, Shams Riaz, Tariq Ismail
Int. J. Biosci.18( 6), 42-50, June 2021.
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Abstract

Human, a well-developed multicellular organism might experience substantial health damages caused by a variety of stresses including physical, chemical and biotic. These stresses are responsible for the modification in their gene expression. Many studies on gene expression physical, chemical and biotic stresses have been conducted with the help of DNA microarray technology. The current study reported the co-shared stress-responsive genes under these stresses by utilizing the existing microarray data. Total 22283 genes were studied and 241 genes are linked to being co-shared stress-responsive. Among these stress-responsive genes, 207 were identified as up-regulated and 34 as down-regulated. All co-shared stress-responsive genes were further characterized with respect to their GO functions and chromosome number.

VIEWS 15

Aerssens J,  Armstrong M, Gilissen R, Cohen N. 2001. The Human Genome: An Introduction. The Oncologist.6, 100-9.

Agapitov AV, Haynes WG. 2002. Role of endothelin in cardiovascular   disease. Journal of Renin Angiotensin Aldosterone System 3(1), 1–15.

Andersson M, Karlsson L, Svensson P, Ulfhammer E, Ekman M, Jernas M. 2005. Differential global gene expression response patterns of human endothelium exposed to shear stress and intraluminal pressure. Journal of vascular research. 42, 441-52.

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM. 2000. Gene Ontology: tool for the unification of biology. Nature Genetics 25(1), 25-29. http://dx.doi.org/10.1038/75556

Bada M, Stevens R, Goble C, Gil Y, Ashburner, M, Blake JA. 2004. A Short Study on the Success of the Gene Ontology. Journal of Web Semantics 1(2), 235–40.

Barret T, Troup DB, Wilhite SE, Ledoux P, Rudnev D, Evangelista C. 2007. NCBI GEO: mining tens of millions of expression profile­­­-database and tools update. Nucleic Acid Research 35, 760-65. http://dx.doi.org/10.11093/nar/gkl887.

Brogden KA, Guthmiller editors JM. 2002. Polymicrobial Diseases. Washington (DC): ASM Press.

Campo MD, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT. 1999. Monodactylous Limbs and Abnormal Genitalia Are Associated with Hemizygosity for the Human 2q31 Region That Includes the HOXD Cluster. American Journal of Human Genetics 65, 104–10.

Carlström M. 2007. Effects of Biomechanical Stress on Gene Regulation in Vascular Cells. Göteborg, Sweden.

Cheng Q, Chang JT, Geradts J, Neckers LM, Haystead T, Spector NL. 2012. Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. Breast Cancer Research. 14.

Choi CH, Choi JJ, Park YA, Lee YY, Song SY, Sung CO. 2012. Identification of differentially expressed genes according to chemosensitivity in advanced ovarian serous adenocarcinomas: expression of GRIA2 predicts better survival. British journal of Cancer 107(1), 91-99.

Duda-Chodak A, Blaszczyk U. 2008. Review paper: The Impact of Nickel on Human Health. Journal of Elementology. 13(4), 685-96.

Goyer R, Golub M, Choudhury H, Hughes M, Kenyon E, Stifelman M. 2004. Issue paper on Human health effects of metals. U.S. Environmental Protection Agency.

Hedge P, Qi R, Abernathy K, Gay C, Dharap S, Gaspard R. 2000. A Concise Guide to cDNA Microarray Analysis. Bio Techniques 29(3), 548-62.

Howe E, Holton K, Nair S, Schlauch D, Sinha R, Quackenbush J. 2010. MeV: MultiExperiment Viewer. Biomedical Informatics for Cancer Research. 267-77.

Lesk AM. 2002. Introduction to Bioinformatics. Oxford university press, p 93-94. ISBN 0 19 925196 7.

Liu J, Li X, Dong GL, Zhang HW, Chen DL, Du JJ. 2008. In silico analysis and verification of S100 gene expression in gastric Cancer. BMC Cancer. 8(261). http://dx.doi.org/10.1186/1471-2407-8-261

Liu Y, Mittal R, Solis NV, Prasadarao NV, Filler SG. 2011. Mechanisms of Candida albicans trafficking to the Brain. PLOS Pathogens 7(10). http://dx.doi.org/10.1371/journal.ppat.1002305

Mader SS. 2004. Human Biology (8thed), McGraw – Hill. ISBN 0-07-234732-5.

Montgomery DC. 1997. Design and Analysis of Experiments (4th edition). New York:  John Wiley & Sons.

Muller V, Viemann D, Schmidt M, Endres N, Ludwig S, Leverkus M. 2007. Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells. The journal of Immunology 179, 8435-45.

Rubin BA. 1993. Clinical picture and Epidemiology of Adenovirus infections (A Review). Acta Microbiological Hungarica 40(4), 303-23.

Sjögren LS,  Doroudi R, Gan L,   Jungersten L, HrafnkelsdóttirJern S. 2000. Elevated Intraluminal Pressure Inhibits Vascular Tissue Plasminogen Activator Secretion and Downregulates Its Gene Expression. Hypertension 35(4), 1002-8. http://dx.doi.org/10.1161/01.HYP.35.4.1002.

Stanislaus A, Bakhtiar A, Salleh D, Tiash S, Fatemian T, Hossain S. 2012. Knockdown of PLC-gamma-2 and calmodulin 1 genes sensitizes human cervical adenocarcinoma cells to doxorubicin and paclitaxel. Cancer Cell International 12, 30.

Ushigome M, Ubagai T, Fukuda H, Tsuchiya N, Sugimura T, Takatsuka J. 2005. Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers. International journal of Oncology 26(3), 635-40.

Viemann D, Schmidt M, Tenbrock K, Schmid S, Müller V, Klimmek K. 2007. The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. The journal of Immunology 178(5), 3198-207.

Vorburger SA Hunt KK. 2002. Adenoviral Gene Therapy. The Oncologist 7, 46-59. http://dx.doi.org/10.1634/theoncologist.7-1-46.

Yano M, Naito Z, Yokoyama M, Shiraki Y, Ishiwata T, Inokuchi M. 1999. Expression of hsp90 and cyclin D1 in human breast cancer. Cancer Letters 137(1), 45-51.

Yim WC, Min K, Jung D, Lee B, Youngeun. 2011. Cross experimental.