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Investigation of liver function tests (LFTs) and renal function tests (RFTs) in pregnant women affected with hypertensive disorders of pregnancy (HDP)

By: Haleema Sadia, Rafia Batool, Rubina Mansoor, Bilal Qureshi, Sana Ashiq, Asma Irshad, Muhammad Riaz, Kanwal Ashiq

Key Words: Total Bilirubin, LFTs, RFTs, Hypertensive disorders of Pregnancy, Pre eclampsia.

Int. J. Biosci. 14(5), 86-94, May 2019.

DOI: http://dx.doi.org/10.12692/ijb/14.5.86-94

Certification: ijb 2019 0013 [Generate Certificate]

Abstract

Hypertensive disorders of pregnancy (HDP) are major health burdens in obstetric population and almost 12-22% pregnancies are affected by HDP in the world. In patients with HDP, liver and renal functions abnormality can negatively affect both maternal and fetal health. The present study was performed to compare changes of liver and renal functions in pregnant women suffering with hypertensive disorders.  Blood samples of 200 patients who attended the Holy Family Hospital, Rawalpindi were collected randomly and were checked for LFTs and RFTs.  Automated chemical analyzer (Beckmann Colter or Selectra) was used; some samples were also quantified by Microlab-300 manually. Out of these 200 patients, 90 (45%), 59 (29.5%),16 (8%), 11 (5.5%)  and 24 (12%) women were diagnosed with the Gestational HTN, Pre-eclampsia, Chronic HTN, Pre-eclampsia superimposed on Chronic HTN and Eclampsia respectively. Total bilirubin, ALT and ALP were increased in 60 (30%), 59 (29.5%) and 85 (42.5%) samples respectively while urea, creatinine and uric acid were increased in 46 (23%), 49 (24.5%) and 91 (45.5%) patients, respectively. Almost 75% patients had 31-40 weeks gestational period, 83% patients had no pre- history and 73% had no family history. Almost, 95 % HDP patients were between 17-40 years. Mortality and morbidity rate is higher in developing countries including Pakistan. So, it is recommended to perform the regular examination of LFTs and RFTs in the HDP patients because early diagnosis and treatment can eradicate the risk of mortality of mother and fetus.

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Investigation of liver function tests (LFTs) and renal function tests (RFTs) in pregnant women affected with hypertensive disorders of pregnancy (HDP)

Bainbridge SA, Roberts JM. 2008. Uric acid as a pathogenic factor in preeclampsia. Placenta  29, 67-72.

Bhowmik DK, Akhtari R, Kumar SU, Saha M, Adhikary DK. 2013. Alteration of Liver Function in Preeclampsia and Eclampsia. Chattagram Maa-O-Shishu Hospital Medical College Journal 12, 9-10.

Brown MA, Gustaaf A, Stephen G, McLintock CK, McMahon LP, Mangos G, Walters B. 2009. Guidelines for the management of hypertensive disorders of pregnancy 2008. Australian and New Zealand Journal of Obstetrics and Gynaecology 49, 242-246.

Ekun OA, Olawumi OM, Makwe CC, Ogidi NO. 2018. Biochemical Assessment of Renal and Liver Function among Preeclamptics in Lagos Metropolis. International journal of reproductive medicine 2018, 1-6.

Hutcheon JA., Lisonkova S, Josep K. 2011. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Practice and Research Clinical Obstetrics and Gynaecology 25, 391-403.

Jan MR, Nazli R, Shah J, Akhtar T. 2012. A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the north west frontier province-Pakistan. Hypertension in Pregnancy 31, 292-299.

Korejo R, Bhutta S, Noorani KJ, Bhutta ZA. 2007. An audit and trends of perinatal mortality at the Jinnah Postgraduate Medical Centre, Karachi. Journal of Pakistan Medical Association 31, 168-171.

Kuklina EV, Ayala C, Callaghan WM. 2009. Hypertensive disorders and severe obstetric morbidity in the United States. Obstetrics & Gynecology 113, 1299-1306.

Lee NM, Brady CW. 2009. Liver disease in pregnancy. World Journal of gastroenterology 15, 897-906.

Lindheimer MD, Taler SJ, Cunningham FG. 2008. Hypertension in pregnancy. Journal of the American Society of Hypertension 2, 484-494.

Lindheimer MD, Taler SJ, Cunningham FG. 2009. ASH position paper: hypertension in pregnancy. The Journal of Clinical Hypertension 11, 214-225.

Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P, Audibert F, Eastabrook G. 2014. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. Journal of Obstetrics and Gynecology Canada 36, 416-438.

Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Pedata R. 2009. Hypertensive disorders of pregnancy.  Journal of Prenatal Medicine 3, 1-5.

Rodriguez MA, Kumar SK, De Caro M. 2010. Hypertensive crisis. Cardiol. Rev 18, 102-107.

Sajith M, Nimbargi V, Modi A, Sumariya R, Pawar A. 2014. Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy. International Journal of Pharma Sciences and Research 23, 163-170.

Say L, Chou D, Gemmill A, Tunçalp Ö, Moller AB, Daniels J, Metin A, Alkema L. 2014. Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health 2, e323-e333.

Shamsi U, Hatcher J, Shamsi A, Zuberi N, Qadri Z, Saleem S. 2010. A multicentre matched case control study of risk factors for preeclampsia in healthy women in Pakistan. BMC women’s health 10, 14

Sibai BM, Stella CL. 2009. Diagnosis and management of atypical preeclampsia-eclampsia. American Journal of Obstetrics and Gynecology 200, 481. e481-481. e487.

Sirajwala HB, Sharma D, Agravatt AM. 2013. A study of serum total calcium and uric acid levels in preeclampsia. Indian Journal of Basic and Applied Medical Research 3, 50-56.

Sliwa K, Böhm M. 2014. Incidence and prevalence of pregnancy-related heart disease. Cardiovascular Research 101, 554-560.

Tayrab E, Saladdin S. 2016. Biochemical and hematological evaluations in sudanese women with preeclampsia. Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry 4, 1-7.

Young BC, Levine RJ,  Karumanchi SA. 2010. Pathogenesis of preeclampsia. Annual Review Pathology: Mechanism of disease 5, 173-192.

Haleema Sadia, Rafia Batool, Rubina Mansoor, Bilal Qureshi, Sana Ashiq, Asma Irshad, Muhammad Riaz, Kanwal Ashiq.
Investigation of liver function tests (LFTs) and renal function tests (RFTs) in pregnant women affected with hypertensive disorders of pregnancy (HDP).
Int. J. Biosci. 14(5), 86-94, May 2019.
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