International network for natural sciences – research journal
  • mendeley icon
  • linkedin icon
  • google plus icon
  • twitter icon
  • google scholar icon
  • facebook icon

Mollugo oppositifolia leaf tea formulation and its effect against alloxan-induced hyperglycemic male sprague dawley rats

By: Vian Jethro T. Bariuan, Chasey T. Mabborang, Sheila Mae G. Macanas, Kenneth Christian O. Santiago, Jayvee B. Salomon, Jinky Marie T. Chua, Ramelo B. Ramirez Jr

Key Words: Mollugo oppositifolia, Hyperglycemia, Tea-bag, Spray-dried.

Int. J. Biosci. 16(4), 71-78, April 2020.

DOI: http://dx.doi.org/10.12692/ijb/16.4.71-78

Certification: ijb 2020 0072 [Generate Certificate]

Abstract

Hyperglycemia is one of the most prevalent health concerns worldwide which is rapidly increasing in middle and low–income families. Though Mollugo oppositifolia Linn. Is found throughout the Philippines, its blood glucose-lowering activity in its tea form has not been studied. The study was conducted to determine the hypoglycemic effects in tea – bag and spray – dried form on Sprague Dawley rats injected with 150 mg of alloxan prepared in 0.9 sodium chloride. It is noted that both tea forms have no significant difference as the commercial drug (Glibenclamide) in lowering the blood glucose concentration. This study also evaluated the formulated leaves based on its moisture content, ash content, and microbial determination, which are all within the acceptable range. Sensory evaluation was also done, and it was found that the taste, color, and aroma show characteristics expected of a green tea. It is recommended that a histopathological test should be conducted on the liver. Furthermore, that the bitter after-taste be masked.

| Views 64 |

| Views 64 |

Mollugo oppositifolia leaf tea formulation and its effect against alloxan-induced hyperglycemic male sprague dawley rats

Ahmed AM. 2012. Medical plant and human health. In: Ghista DN (ed) Biomedical science, engineering and technology. Intech, 165–190.

http://www.intechopen.com/books/biomedicalscience-engineering-and-technology/medical-plant-and-humanhealth

American Diabetes Association. 2019. Standards of Medical Care in Diabetes 2019. The Journal of Clinical and Applied Research and Education: Diabetes Care 42.

Arif T, Sharma B, Gahlaut A, Kumar V, Danbur R. 2014. Anti-diabetic agents from medicinal plants: a review. Chemical Biology Letters 1, 1–13.

Chang CLT, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. 2013. Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds. Evidence-base complementary and alternative medicine.

https://doi.org/10.1155/2013/378657

Eroglu E, Tontul I, Topuz A. 2018. Optimization of aqueous extraction and spray drying conditions for efficient processing of hibiscus blended rosehip tea powder. Journal of Food Processing and Preservation 42, 1-9.

https://doi.org/10.1111/jfpp.13643

Falciglia M, Freyberg RW, Almenoff PL, D’Alessio DA, Render ML. 2009. Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Critical Care Medicine 37, 3001-3009. https://doi.org/10.1097/CCM.0b013e3181b083f7

Ferrara A, Hedderson MM, Albright CL, Brown SD, Ehrlich SF, Caan BJ, Quesenberry CP. 2014. A pragmatic cluster randomized clinical trial of diabetes prevention strategies for women with gestational diabetes: Design and rationale of the Gestational Diabetes’ Effects on Moms (GEM) study. BMC Pregnancy and Childbirth 14, 21.

https://doi.org/10.1186/1471-2393-14-21

Hosoda K, Wang MF, Liao ML, Iha M, Clevidence B, Yamamoto S. 2003. Antihyperglycemic Effect of Oolong Tea in Type 2 Diabetes. Diabetes Care 26, 1714-1718.

https://doi.org/10.2337/diacare.26.6.1714

Jayawardenaa MHS, de Alwisa NMW, Hettigodaab V, Fernando DJS. 2005. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. Journal of Ethnopharmacology 97, 215-218.

https://doi.org/10.1016/j.jep.2004.10.026

Jerine PS, Sabina EP. 2016. Global current trends in natural products for diabetes management: a review. International Journal of Pharmacy and Pharmaceutical Sciences 8, 20–28.

https://innovareacademics.in/journals/index.php/ijpps/article/view/10515.

Kabilan SJ, Baskar R, Poorani G. 2019. Herbal Tea Formulation for Health Rejenuvation: Nutritional, Physicochemical and Sensory Analysis. International Journal of Engineering and Advanced Technology 9.

https://doi.org/10.35940/ijeat.A1144.1291S419

Okafor GI, Ogbobe NM. 2015. Production and Quality Evaluation of Green and Black Herbal Teas from Moringa oleifera Leaf. Journal of Food Resource Science 4, 62-72.

https://doi.org/10.3923/jfrs.2015.62.72

Osadebe P, Odoh E, Uzor P. 2014. Natural products as potential sources of antidiabetic drugs. British Journal of Pharmaceutical Research 4, 2075–2095.

https://doi.org/10.9734/BJPR/2014/8382

Ryan EA, Imes S, Wallace C, Jones S. 2000. Herbal tea in the treatment of diabetes mellitus. Clinical and Investigative Medicine 23, 311-317.

Siddiqui M, Khan M, Carline T. 2013. Gender Differences in Living with Diabetes Mellitus. Materia Socio Medica 25, 140.

https://doi.org/10.5455/msm.2013.25.140-142

Simpson R, Morris GA. 2014. The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review. Bioactive Carbohydrates and Dietary Fibre 3, 106–114.

https://doi.org/10.1016/j.bcdf.2014.03.003

Sonkamble VV, Wagh NS, Kamble LH. 2018. Inhibition of α-amylase and α-glucosidase by (6RS)-22-hydroxy-23, 24, 25, 26, 27-cholestane-3α, 7α, 12α, 24, 25, 26-hexol isolated from acetone extract of Helianthus annuus L. seeds. International Journal of Pharmacy and Pharmaceutical Sciences 10, 39–49. https://doi.org/10.22159/ijpps.2018v10i5.25309

Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. 2004. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacology, 4.

https://doi.org/10.1186/1471-2210-4-18

Whiting DR, Guariguata L, Weil C, Shaw J. 2011. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice 94, 311–321.

https://doi.org/10.1016/j.diabres.2011.10.029

WHO. 2018. Diabetes. Retrieved from

https://www.who.int/newsroom/factsheets/detail/diabetes

Vian Jethro T. Bariuan, Chasey T. Mabborang, Sheila Mae G. Macanas, Kenneth Christian O. Santiago, Jayvee B. Salomon, Jinky Marie T. Chua, Ramelo B. Ramirez Jr.
Mollugo oppositifolia leaf tea formulation and its effect against alloxan-induced hyperglycemic male sprague dawley rats.
Int. J. Biosci. 16(4), 71-78, April 2020.
https://innspub.net/ijb/mollugo-oppositifolia-leaf-tea-formulation-effect-alloxan-induced-hyperglycemic-male-sprague-dawley-rats/
Copyright © 2020
By Authors and International Network for
Natural Sciences (INNSPUB)
https://innspub.net
brand
innspub logo
english language editing
  • CALL FOR PAPERS
    CALL FOR PAPERS
    Publish Your Article
  • CALL FOR PAPERS
    CALL FOR PAPERS
    Submit Your Article
INNSPUB on FB
Email Update