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Nephron-protective effects of curcuma on oxidative damage and oxidative stress in rat under sub-chronic poisoning of chromium

By: Malika Saidi, Ouassila Aouacheri, Saad Saka, Imene Tebboub, Leila Ailane

Key Words: Chromium, Oxidative stress, Curcuma longa, kidney, Rat.

Int. J. Biosci. 15(1), 241-250, July 2019.

DOI: http://dx.doi.org/10.12692/ijb/15.1.241-250

Certification: ijb 2019 0035 [Generate Certificate]

Abstract

The aim of this study is to evaluate the nephroprotective role of Curcuma longa, against acute toxicity effects of hexavalent chromium induced oxidative renal injury. Therefore, different antioxidant and serum biochemical parameters were measured. Male Wistar rats were divided into four groups and were treated daily for 30 consecutive days. Group I (0-0): control rats received mineral water through oral gavage (per os) and were nursed on normal diet. Group II (0-Cur): rats received mineral water and were fed on an experimental diet containing 2 % of curcuma powder. Group III (Cr-0): rats were treated per os with potassium dichromate at a dose of 15 mg/kg of body weight and were fed on normal diet. Group IV (Cr-Cur): rats received an oral dose of potassium dichromate at a dose of 15 mg/kg of body weight and an experimental diet containing 2 % of curcuma powder. Renal protein concentration, glutathione content, glutathione peroxidase, glutathione S-transferase and catalase activities were estimated. Exposure of rats to chromium caused significant perturbation in the renal biomarkers (creatinine, urea, uric acid, albumin, and total proteins), while there was a significant decrease in the oxidative stress parameters (GSH, GPx, GST, and CAT). These disruptions were accompanied by histopathological changes in the kidney sections of rats intoxicated with chromium, whereas treatment with Curcuma longa restored all the parameters mentioned above to near normal. In conclusion, results revealed the potent antioxidants activity of curcuma that were demonstrated by its ameliorative effects on chromium intoxication. Thus, this plant has a protective effect against nephron-damages induced by the hexavalent chromium.

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Nephron-protective effects of curcuma on oxidative damage and oxidative stress in rat under sub-chronic poisoning of chromium

Abdel-Moneim AM, El-Toweissy MY, Ali AM, Awad Allah AAM, Darwish HS, Sadek IA. 2015. Curcumin ameliorates lead (Pb2+)-induced hemato-biochemical alterations and renal oxidative damage in a rat model. Biological Trace Element Research 168(1), 206-620.

http://dx.doi.org/10.1007/s12011-015-0360-1.

Aebi H. 1984. Catalase in vitro. Methods in Enzymology 105, 121-126.

http://dx.doi.org/10.1016/S0076-6879(84)05016-3.

Agarwal R, Goel SK, Behari JR. 2010. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. Journal of Applied Toxicology 30(5), 457-468.

http://dx.doi.org/10.1002/jat.1517.

Aggarwal BB, Surh YJ, Shishodia S. 2007. The molecular targets and therapeutic uses of curcumin in health and disease (Springer, New York).

Ali BH, Al-Salam S, Al Suleimani Y, Al Kalbani J, Al Bahlani S, Ashique M, Manoj P, B Al Dhahli, Al Abri N, Naser HT, Yasin J, Nemmar A, Al Za’abi M, Hartmann C, Schupp N. 2018. Curcumin ameliorates kidney function and oxidative stress in experimental chronic kidney disease. Basic and Clinical Pharmacology and Toxicology 122(1), 65-73.

http://dx.doi.org/10.1111/bcpt.12817.

Alvarenga LA, Leal VO, Borges NA, Silva de Aguiar A, Faxén-Irving G, Stenvinkel P, Lindholmf B, Mafra D. 2018. Curcumin – A promising nutritional strategy for chronic kidney disease patients. Journal of Functional Foods 40, 715-721.

http://dx.doi.org/10.1016/j.jff.2017.12.015.

Aouacheri O, Saka S, Krim M, Messaadia A, Maidi I. 2015. The investigation of the oxidative stress related parameters in type 2 diabetes mellitus. Canadian Journal of Diabetes 39(1), 44-49.

http://dx.doi.org/10.1016/j.jcjd.2014.03.002.

Attia YA, Al-Harthi MA, Hassan SS. 2017. Turmeric (Curcuma longa Linn) as a phytogenic growth promoter alternative for antibiotic and comparable to mannan oligosaccharides for broiler chicks. Revista Mexicana De Ciencias Pecuarias 8(1), 11-21.

http://dx.doi.org/10.22319/rmcp.v8i1.4309.

Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG. 2002. Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 180(1), 5-22.

http://dx.doi.org/10.1016/S0300-483X(02)00378-5.

Boşgelmez II, Güvendik G. 2004. Effects of taurine on oxidative stress parameters and chromium levels altered by acute hexavalent chromium exposure in mice kidney tissue. Biological Trace Element Research 102(1-3), 209-225.

http://dx.doi.org/10.1385/BTER:102:1-3:209.

Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248-254.

http://dx.doi.org/10.1016/0003-2697(76)90527-3.

Bradl H. 2005. Heavy metals in the environment: Origin, interaction and remediation 6, London: Academic Press.

Coetzee JJ, Bansal N, Chirwa EMN. 2018. Chromium in environment, its toxic effect from chromite-mining and ferrochrome industries, and its possible bioremediation. Exposure and Health 2018, 1-12.

http://dx.doi.org/10.1007/s12403-018-0284-z.NYP.

De Flora S, Camoirano A, Micale RT, La Maestra S, Savarino V, Zentilin P, Marabotto E, Suh M, Proctor DM. 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity. Toxicology and Applied Pharmacology 306, 113-119.

http://dx.doi.org/10.1016/j.taap.2016.07.004.

Dodiya H, Jain M, Goswami S. 2011. Study of urinary biomarkers for nephrotoxicity in wistar rats. Journal of Pharmacology and Toxicology 6(6), 571-579.

http://dx.doi.org/10.3923/jpt.2011.571.579.

Fisher RA, Yates R. 1974. Statistical Tables for Biological, Agricultural and Medical Research (London: Longman Group).

Flohé L, Günzler WA. 1984. Assays of glutathione-peroxidase. Methods in Enzymology 105, 114-121.

http://dx.doi.org/10.1016/S0076-6879(84)05015-1.

Gad SC. 1989. Acute and chronic systemic chromium toxicity. Science of the Total Environment 86(1-2), 149-157.

http://dx.doi.org/10.1016/0048-9697(89)90201-5.

Grassi D, Ferri L, Desideri G, Di Giosia P, Cheli P, Del Pinto R, Properzi G, Ferri C. 2013. Hyperuricemia, uric acid deposit and cardiovascular risk. Current Pharmaceutical Design 19(13), 2432-2438.

http://dx.doi.org/10.2174/1381612811319130011.

Gutteridge JM. 1995. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry 41(12 Pt 2), 1819-1828.

Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 249, 7130-7139.

Hojo Y, Satomi Y. 1991. In vivo nephrotoxicity induced in mice by chromium (VI). Involvement of glutathione and chromium (V). Biological Trace Element Research 31(1), 21-31.

Julian BA, Suzuki H, Suzuki Y, Tomino Y, Spasovski G, Novak J. 2009. Sources of urinary proteins and their analysis by urinary proteomics for the detection of biomarkers of disease. Proteomics – Clinical Applications 3, 1029-1043.

http://dx.doi.org/10.1002/prca.200800243.

Kehili N, Saka S, Aouacheri O. 2017. L’effet phytoprotecteur de la nigelle (Nigella sativa) contre la toxicité induite par le cadmium chez les rats. Phytothérapie 1, 1-10.

http://dx.doi.org/10.3166/phyto-2018-0053.

Kelley WN, Weiner IM. 1978. Handbook of experimental pharmacology: continuation of handbuch der experimentellen pharmakologie 51, New York: Berlin Heidelberg).

Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, Block ER, Prabhakar S, Johnson RJ. 2005. Hyperuricemia induces endothelial dysfunction. Kidney International 67(5), 1739-1742.

http://dx.doi.org/10.1111/j.1523-1755.2005.00273.x.

Kim HY, Lee SB, Jang BS. 2004. Subchronic inhalation toxicity of soluble hexavalent chromium trioxide in rats. Archives of Toxicology 78, 363-368.

http://dx.doi.org/10.1007/s00204-004-0553-4.

Kumar A, Barthwal R. 1991. Hexavalent chromium effects on hematological indices in rats. Bulletin of Environmental Contamination and Toxicology 46(5), 761-768.

Lim TK. 2016. Edible medicinal and non-medicinal plants (London: Roots, Bulbs).

Lin CC, Wu ML, Yang CC, Ger J, Tsai WJ, Deng JF. 2009. Acute severe chromium poisoning after dermal exposure to hexavalent chromium. Journal of the Chinese Medical Association 72(4), 219-221.

http://dx.doi.org/10.1016/S1726-4901(09)70059-0.

Luthra PM, Singh R, Chandra R. 2001. Therapeutic uses of Curcuma longa (turmeric). Indian Journal of Clinical Biochemistry 16(2), 153-160.

http://dx.doi.org/10.1007/BF02864854.

Momeni HR, Eskandari N. 2017. Effect of curcumin on kidney histopathological changes, lipid peroxidation and total antioxidant capacity of serum in sodium arsenite-treated mice. Experimental and Toxicologic Pathology 69(2), 93-97.

http://dx.doi.org/10.1016/j.etp.2016.08.006.

Nabavi SF, Moghaddam AH, Eslami S, Nabavi SM. 2012. Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys. Biological Trace Element Research 145, 369-374.

http://dx.doi.org/10.1007/s12011-011-9194-7.

Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, Rodriguez-Iturbe B, Herrera-Acosta J, Johnson RJ. 2003. Hyperuricemia causes glomerular-hypertrophy in the rat. American Journal of Nephrology 23(1), 2-7.

http://dx.doi.org/10.1159/000066303.

Sahu BD, Koneru M, Bijargi SR, Kota A, Sistla R. 2014. Chromium-induced nephrotoxicity and ameliorative effect of carvedilol in rats: Involvement of oxidative stress, apoptosis and inflammation. Chemico-Biological Interactions 223, 69-79.

http://dx.doi.org/10.1016/j.cbi.2014.09.009.

Saka S, Aouacheri O. 2017. The investigation of the oxidative stress-related parameters in high doses methotrexate-induced albino wistar rats. Journal of Bioequivalence and Bioavailability 9(2), 372-376. http://dx.doi.org/10.4172/jbb.1000327.

Salama SM, Abdulla MA, AlRashdi AS, Ismail S, Alkiyumi SS, Golbabapour S. 2013. Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complementary and Alternative Medicine 13(56), 1-17.

http://dx.doi.org/10.1186/1472-6882-13-56.

Shil K, Pal S. 2018. Metabolic adaptability in hexavalent chromium-treated renal tissue: an in vivo study. Clinical Kidney Journal 11(2), 222–229.

http://dx.doi.org/10.1093/ckj/sfx069.

Silbergeld EK, Waalkes M, Rice JM. 2000. Lead as a carcinogen: experimental evidence and mechanisms of action. American Journal of Industrial Medicine 38, 316-323.

http://dx.doi.org/10.1002/10970274(200009)38:3<316::AID-AJIM11>3.0.CO;2-P.

So A, Thorens B. 2010. Uric acid transport and disease. Journal of Clinical Investigation 120(6), 1791-1799.

http://dx.doi.org/10.1172/JCI42344.

Soudani N, Sefi M, Bouaziz H, Chtourou Y, Boudawara T, Zeghal N. 2011. Nephrotoxicity induced by chromium (VI) in adult rats and their progeny. Human and Experimental Toxicology 30(9), 1233-1245.

http://dx.doi.org/10.1177/0960327110387454.

Sreepriya M, Bali G. 2005. Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Fitoterapia 76(6), 549-555.

http://dx.doi.org/10.1016/j.fitote.2005.04.014.

Sun H, Brocato J, Costa M. 2015. Oral chromium exposure and toxicity. Current Environmental Health Reports 2, 295-303.

http://dx.doi.org/10.1007/s40572-015-0054-z.

Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. 2013. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biology 1, 448-456.

http://dx.doi.org/10.1016/j.redox.2013.09.003.

Upreti KK, Das M, Kumar A, Singh GB, Khanna SK. 1989. Biochemical toxicology of argemone oil. IV. Short-term oral feeding response in rats. Toxicology 58, 285-298.

http://dx.doi.org/10.1016/0300-483X(89)90142-X.

Vargas-Santos AB, Neogi T. 2017. Management of gout and hyperuricemia in CKD. American Journal of Kidney Diseases 70(3), 422-439.

http://dx.doi.org/10.1053/j.ajkd.2017.01.055.

Venter C, Oberholzer HM, Cummings FR, Bester MJ. 2017. Effects of metals cadmium and chromium alone and in combination on the liver and kidney tissue of male Spraque- Dawley rats: An ultrastructural and electron-energy-loss spectroscopy investigation. Microscopy Research and Technique 80(8), 878-888.

http://dx.doi.org/10.1002/jemt.22877.

Venter C, Oberholzer HM, Taute H, Cummings FR, Bester MJ. 2015. An in ovo investigation into the hepatotoxicity of cadmium and chromium evaluated with light- and transmission electron microscopy and electron energy-loss spectroscopy. Journal of Environmental Science and Health – Part A Toxic/Hazardous Substances and Environmental Engineering 50(8), 830-838.

http://dx.doi.org/10.1080/10934529.2015.1019804.

Weckbercker G, Cory JG. 1988. Ribonucleotide reductase activity and growth of glutathione-depended mouse leukaemia L1210 cells in vitro. Cancer Letters 40, 257-264.

http://dx.doi.org/10.1016/0304-3835(88)90084-5.

Zhong W, Zhang Y, Wu Z, Yang R, Chen X, Yang J. 2018. Health risk assessment of heavy metals in freshwater fish in the central and eastern North China. Ecotoxicology and Environmental Safety 157, 343-349.

http://dx.doi.org/10.1016/j.ecoenv.2018.03.048

Malika Saidi, Ouassila Aouacheri, Saad Saka, Imene Tebboub, Leila Ailane.
Nephron-protective effects of curcuma on oxidative damage and oxidative stress in rat under sub-chronic poisoning of chromium.
Int. J. Biosci. 15(1), 241-250, July 2019.
https://innspub.net/ijb/nephron-protective-effects-curcuma-oxidative-damage-oxidative-stress-rat-sub-chronic-poisoning-chromium/
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