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Philippine ethnobotanicals show anti-proliferative and cytotoxic activities in human breast cancer cells (MCF-7)

By: Edlyn E. Pooten, Glenn G. Oyong, Khristina G. Judan Cruz

Key Words: Breast cancer, MCF-7, Philippine ethno botanicals.

Int. J. Biosci. 13(5), 239-251, November 2018.

DOI: http://dx.doi.org/10.12692/ijb/13.5.239-251

Certification: ijb 2018 0024 [Generate Certificate]

Abstract

The increasing trend and threat of breast cancer had paved the search for novel compounds to discover drugs for its treatment. Since the discovery and development of plant-based anti-tumor drugs, plants has been the focus of several researches to discover species with pharmacological potential. The Philippine Ilongot-Egongot ethno botanicals were tested for anti-proliferative and cytotoxic activities to determine their anticancer potential against breast adenocarcinoma (MCF-7) cancer cell line using PrestoBlue® Assay. Nine extracts showed toxic effects on MCF-7 cells: Cestrum nocturnum, Sarcandra glabra, Oreocnide trinervis, Pittosporum pentandrum, Derris elliptica, Alstonia scholaris, Ageratina adenophora, Ayapana triplinervis and Lop-lopiit (no known scientific name), Two extracts showed anticancer activity against MCF-7 while being nontoxic to the normal cells (normal primary dermal fibroblast, neonatal (HDFn): O. trinervis and A. triplinervis. This preferential toxicity makes these enthnobotanicals ideal candidates for anti-cancer drug discovery and development.

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Philippine ethnobotanicals show anti-proliferative and cytotoxic activities in human breast cancer cells (MCF-7)

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Edlyn E. Pooten, Glenn G. Oyong, Khristina G. Judan Cruz.
Philippine ethnobotanicals show anti-proliferative and cytotoxic activities in human breast cancer cells (MCF-7).
Int. J. Biosci. 13(5), 239-251, November 2018.
https://innspub.net/ijb/philippine-ethnobotanicals-show-anti-proliferative-cytotoxic-activities-human-breast-cancer-cells-mcf-7/
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