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Pseudomonas aeruginosa as a pathogenic Organism

By: Sidra Mengal, Saima Azam, Muhammad Kamran Taj, Fazal ur Rehman, Umbreen Zafar, Ajmal Nisar Mengal, Ashiq Hussain, Imran Taj, Zohra Samreen, Farooq Shahzad, Hasina wali, Syeda Ayesha Ali, Syeda Hafsa Ali

Key Words: Pseudomonas, Aeruginosa, Pathogenic, Resistance, Infections.

Int. J. Biosci. 14(4), 286-291, April 2019.

DOI: http://dx.doi.org/10.12692/ijb/14.4.286-291

Certification: ijb 2019 0001 [Generate Certificate]

Abstract

Pseudomonas aeruginosa, is a member of the Pseudomonadaceae family. Pseudomonas aeruginosa is an opportunistic pathogen commonly found in the environment mainly in soil and water, but is also regularly found on plants and sometimes on animals, including humans. Pseudomonas aeruginosa is an important pathogen in healthcare-associated infections. Pseudomonas aeruginosa cause a variety of infections such as chronic CF lung infection, acute septicemia, wound infection, urinary tract infection, corneal ulceration, endocarditis, and pneumonia. P. aeruginosa also has a large number of virulence factors such as adhesions exotoxin A, exoenzyme S, nan 1 and Las genes, Mucoid exopolysaccharide, Protease enzymes, Lipopolysaccharide, Pigments eg. pyocyanin, 1-hydroxyphenazine, pyoverdin, Phospholipase C, Rhamnolipid, Pili, Lipase, Histamine, and Leukocidin. During pathogenesis P. aeruginosa quorum sensing plays a critical role for survival and colonization by coordinating phenotypic alterations at early stages of infection. Pseudomonas skin and soft tissue infections can be destructive and can cause massive necrosis and gangrene. Pseudomonas aeruginosa is resistant to quinolones, tetracycline, chloramphenicol while It is sensitive to gentamicin. This information about Pseudomonas aeruginosa will help to a better understanding of infectious processes and will allow to develop new effective procedure for prevention and clinical treatment.

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Pseudomonas aeruginosa as a pathogenic Organism

Alex LA, Simon MI. 1994. Protein histidine kinases and signal transduction in prokaryotes and eukaryotes. Trends in Genetics 10, 133-138.

Armour AD, Shankowsky HA, Swanson T, Lee J, Tredget EE. 2007. The impact of nosocomially-acquired resistant Pseudomonas aeruginosa infection in a burn unit. Journal of Trauma 63(1),164-171.

Aylin AEGA, Gokce PY. 2012. A Modified Selective Medium Containing Benzalkonium Chloride (BKC) for the Isolation of Pseudomonas aeruginosa from Raw Milk. Food Nutrition Sciences 3, 947-950.

Barr HLHalliday NCámara MBarrett DAWilliams PForrester DLSimms RSmyth ARHoneybourne DWhitehouse JLNash EFDewar JClayton AKnox AJFogarty AW. 2015. Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis. European Respiratory Journal 46, 1046-1054.

Bitter W. 2003. Secretins of Pseudomonas aeruginosa: large holes in the outermembrane. Archives of Microbiology. 179, 307-314.

Bodey GP, Bolivar R, Fainstein V, Jadeja L. 1983. Infections caused by Pseudomonas aeruginosa. Review of Infection Diseases 5, 279-313.

De VDLim AJRPirnay JPStruelens MVandenvelde CDuinslaeger LVanderkelen ACornelis P. 1997. Direct detection and identification of Pseudomonas aeruginosa in clinical samples such as skin biopsy specimens and expectorations by multiplex PCR based on two outer membrane genes, oprI and oprL. Journal of Clinical Microbiology 35, 1295-1299.

Douraghi M, Soltan D, Rahbar M, Rahimiforoushani A. 2014. Molecular identification of Pseudomonas aeruginosa recovered from cystic fibrosis patients. Journal of Preventive Medicine and Hygiene 55, 5053.

Elizabeth B, HirschVincent HT. 2010. Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes, Expert Review of Pharmacoeconomics & Outcomes Research  10(4), 441-451.

Euzeby JP. 1997. List of Bacterial Names with Standing in Nomenclature: a folder available on the Internet. International Journal of Systemic Bacteriology 47, 590-592.

González JE, Keshavan ND. 2006. Messing with bacterial quorum sensing. Microbiology and Molecular Biology. Reviews 70, 859-875.

Govan JR, Deretic V. 1996. Microbial pathogenesis in cystic fibrosis:mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiology Reviews60, 539-574.

Heal CF, Buettner PG, Cruickshank R, Graham D, Browning S, Pendergast J, Drobetz HGluer RLisec C. 2009. Does single application of topical chloramphenicol to high risk sutured wounds reduce incidence of wound infection after minor surgery? Prospective randomised placebo controlled double blind trial. British Medical Journal338, 2812. doi: 10.1136/bmj.a2812.

Jombo GTJonah PAyeni JA. 2008. Multiple resistant Pseudomonas aeruginosa in contemporary medical practice: findings from urinary isolates at a Nigerian University Teaching Hospital. Nigerian Journal of Physiological Sciences 23(1-2),105-109.

Khan J, Iqbal Z, Saeed R, Kalsoom F. 2002.Prevalence of resistance pattern of P. aeroginosa against various antibiotics. Pakistan Journal of Pharmacology 3, 311-315.

Lowbury EJL, Thomas BT, Lilly HA, Babb JR, Whittall K. 1970. Sources of infection with Pseudomonas aeruginosa in patients with tracheostomy. Journal of Medical Microbiology 3, 39-56.

Mantengoli G.2005. Treatment and control of severe infections caused by multiresistant Pseudomonas aeruginosa. Review Clinical Microbiolog Infection 11, 17-32.

Mittal R, Aggarwal S, Sharma S, Chhibber S, Harjai K. 2009.Urinary tract infections caused by Pseudomonas aeruginosa: a mini review. Journal of Infection and Public Health 2(3), 101-111.

Nagachandrikaa T, Kumarb U, Dumpatic S, Charyc S, Mandatharac PS, Rathi VM. 2011. Prevalence of contact lens related complications in a tertiary eye centre in India. Contact Lens & Anterior Eye. 34(6), 266-268.

Nikaido H. 1994. Prevention of drug access to bacterial targets: Permeability barriers and active efflux. Science 264, 382-388.

Ninkovic G, Dullo V, Saunders NC. 2008.Microbiology of otitis externa in the secondary care in United Kingdom and antimicrobial sensitivity. Auris Nasus Larynx 35(4), 480-484. doi: 10.1016/j.anl.2007.09.013.

Nixon GM, Armstrong DS, Carzino R, Carlin JB, Olinsky A, Robertson CF, Grimwood K. 2001. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. Journal of Paediatry. 138(5), 699-704.

Pollack M. 2000. Pseudomonas Aeruginosa. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 5th ed. New York, NY: Churchill Livingstone 2310-2327.

Prabhat KR, Satish NRKB, Arora DR. 2010. Prevalence of Pseudomonas aeruginosa in Post-operative Wound Infection in a Referral Hospital in Haryana, Indian Journal of Lab Physicians 2(2), 74-77.

Ras GJ, Anderson R, Taylor GW, Savage JE, Van Niekerk E, Wilson R, Cole PJ. 1990. Proinflammatory interactions of pyocyanin and 1-hydroxyphenazine with human neutrophil in vitro. Journal of Infectious Diseases 162, 178-185.

Ratjen F, Munck A, Kho P, Angyalosi G. 2010. Treatment of early Pseudomonas aeruginosa infection in patientswith cystic fibrosis: the ELITE trial. Thorax 65(4), 286-291. doi: 10.1136/thx.2009.121657

Roberston DM, Petroll WM, Jester JV, Cavanagh HD. 2007. Current concepts: contact lens related Pseudomonas keratitis. Contact Lens  & Anterior Eye. 30(2), 94-107.

Smith JJ, Travis SM, Greenberg EP, Welsh MJ. 1996.Cystic fibrosis airway epithelial fail to kill bacteria of abnormal airway surface fluid. Cell 85(2), 229-236.

Stern GA, Lubniewski A, Allen C. 1985. The interaction between Pseudomonas aeruginosa and the corneal epithelium. Arch Ophthalmol 103(8), 1221-1225.

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P. 2000. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 406,959-964.

Van DC, Iglewski BH. 1998. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerging Infection Disease 4, 551-560.

Wang MC, Liu CY, Shiao AS, Wang T. 2005. Ear problems in swimmers. Journal of China Medical Assocation 68(8), 347-352.

Zahraa MJ, Maysaa ARD, Abdul KHAb, Safaa MJ. 2014. Molecular identification and antibiotics resistance genes profile of Pseudomonas aeruginosa isolated from Iraqi patients .African Journal of Microbiology Research 8(21), 2183-2192, DOI: 10.5897/AJMR2013.6472

Sidra Mengal, Saima Azam, Muhammad Kamran Taj, Fazal ur Rehman, Umbreen Zafar, Ajmal Nisar Mengal, Ashiq Hussain, Imran Taj, Zohra Samreen, Farooq Shahzad, Hasina wali, Syeda Ayesha Ali, Syeda Hafsa Ali.
Pseudomonas aeruginosa as a pathogenic Organism.
Int. J. Biosci. 14(4), 286-291, April 2019.
https://innspub.net/ijb/pseudomonas-aeruginosa-pathogenic-organism/
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