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Serum resistin levels in patients with type 2 diabetes mellitus and its relationship with glycosylated hemoglobin

By: Maheen Saad, Fatima Ehsan, Kirn-e-Muneera, Muhammad Adnan Saeed, Sobia Ali, Hafsa Aziz

Key Words: Resistin levels, Fasting blood glucose and HbA1c, Type 2 diabetes mellitus.

Int. J. Biosci. 15(4), 312-317, October 2019.

DOI: http://dx.doi.org/10.12692/ijb/15.4.312-317

Certification: ijb 2019 0182 [Generate Certificate]

Abstract

To compare serum resistin levels in type 2 diabetic patients (T2DM) and normal controls and to assess the relationship between serum resistin level and glycosylated hemoglobin (HbA1c) in type 2 diabetic patients. The study comprised of two groups i.e. Group A and Group B. Group A consisted of 100 diabetic patients and group B consisted of 100 healthy individuals (control). Blood samples were taken and analyzed for serum resistin, fasting blood glucose (FBG) and glycosylated hemoglobin. SPSS version 19 was used to analyze the data obtained. The values were stated as mean±SD. Assessment of relationship between resistin and HbA1c was done through Pearson’s correlation co-efficient. Type 2 diabetic patients showed significantly higher level of resistin as compared to the normal control (30.4+8.50 vs. 18.9+2.31, p = <0.05).The diabetic group manifested significantly higher values of HbA1c (8.5+1.73 vs. 4.0+0.76) and FBG (158.5+28.30 vs. 84.9+20.01). Serum resistin levels showed a strong positive association (p < 0.001) with glycosylated hemoglobin (r .816) in the diabetic group through Pearson’s correlation co-efficient r. Type 2 DM patients have significantly higher resistin levels than healthy individuals which is positively correlated with fasting blood sugar and  HbA1csupporting the evidence that resistin plays an important role in the pathogenesis of insulin resistance which could indirectly contribute to the development of type 2 DM.

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Serum resistin levels in patients with type 2 diabetes mellitus and its relationship with glycosylated hemoglobin

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Maheen Saad, Fatima Ehsan, Kirn-e-Muneera, Muhammad Adnan Saeed, Sobia Ali, Hafsa Aziz.
Serum resistin levels in patients with type 2 diabetes mellitus and its relationship with glycosylated hemoglobin.
Int. J. Biosci. 15(4), 312-317, October 2019.
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