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Serum urea, uric acid and creatinine levels in diabetic mellitus patients attending Jos University Teaching Hospital, North central Nigeria

By: Ediale Joshua Richard, Adugba Oko Augustine, Celestine Okafor Ani, Paschal Uwadiegwu Chime, Uzoigwe Uzowulu Jide, Agu Uchenna Francis, Okorie Onyinye Pamela, Nworgu Choice Chinemerem, Adaobi Bisi Onyemaechi, Ebute Charles Paul

Key Words: Diabetics, Non-diabetic, Serum urea, Uric acid, Creatinine

Int. J. Biosci. 11(4), 68-72, October 2017.

DOI: http://dx.doi.org/10.12692/ijb/11.4.68-72

Certification: ijb 2017 0101 [Generate Certificate]

Abstract

Assay of Serum urea, uric acid and creatinine concentrations are important in the management of chronic diseases such as diabetes mellitus. Diabetes mellitus has an effect on the excretion of uric acid and creatinine in different sexes of diabetes mellitus (DM) patients attending Jos University Teaching Hospital (JUTH). This study also compared between urea, uric acid and creatinine concentration in the serum of diabetic (control group). 150 individuals were recruited for this study, seventy four (74) apparently healthy (non-diabetic) subjects were recruited as control and seventy six (76) diabetic subjects. The diabetic consist of thirty eight (38) male and thirty eight (38) females. The non diabetics consist of equal number of thirty seven (37) females and males respectively. The subjects were enlightened and given informed consents prior to the research. They were fasted overnight (12hr) and 5ml pre-prandial blood were collected from cubital vein in the arm the following morning with a sterile syringe, tourniquet and 75% alcohol and needle and the blood transferred to an Ethylenediaminetetraacetic acid (EDTA) bottle and kept at temperature of 20C and later analyzed. The result shows the level of serum (7.9±3.8) and creatinine (200±7.8) uMol/L significantly increased (p<0.05) in diabetic subjects. In male diabetic subjects the serum urea (7.4±3.2) uMol/l and creatinine (218±7.9) were significant. There was also a significant increase (p>0.05) in the female diabetic subjects. Though the serum uric acid level was higher in male diabetic (243±10.6) than the female diabetic (222±10.8), yet there was no significant difference (p>0.05). These values were also higher in male non-diabetic (179±8.4). This study therefore confirms that the assay of serum urea and creatinine concentrations have an important role in the management of diabetic mellitus patients.

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Serum urea, uric acid and creatinine levels in diabetic mellitus patients attending Jos University Teaching Hospital, North central Nigeria

Ani CO, Matthew JO, Chime PU, Anyaeji PS, Nworgu CR, Uzoigwe JU. 2017.Estimation of serum uric urea, uric acid and creatinine in HIV-Positive Patients in Makurdi North Central Nigeria. Journal of Medical Science and Clinical Research .7; 25706-25710 p.

https://dx.doi.org/10.18535/jmscr/v5i7.230

Bauminger BB. 1974. Micro method for manual analysis of true glucose in plasma without deproteination.Journal of .Clinical Pathology.27; pp: 1015-1017.

Burtis CA, Ashwod ER. 2001. Tietzfundamentals of clinical chemistry. (5thedn).W.B Saunders,

Philadelphia 681-738 p.

Caraway WT.1955. Epidemiology of chronic Rheumatism, American Journal of Clinical Pathology. 25, 840.

Http://en.wikipedia.org/diabetes/mellitus

Ireland JI, Thomson WST, William J.1980.Diabetes handbook for clinician. Blackwell Publishers United Kingdom. 121 p.

Matthew D.1968.Clinical investigation of the diabetes mellitus, Editor.Journal of American Medical Association.205-698 p.

Natelson S, Israel S, John EB.1964. Improvement in the method of separation of guanidine organic acid by column chromatography ;isolation and identification of guanidinosuccinic acid from human urine. Microchemical Journal 8, 371-382.

Richard MB, Peter M, Arthur HR, Jeremy  JBe, Rydolf WB, Harry K, John CP. 1984. Blood glucose control and the evolution of Diabetic Retinopathy and Albuminaria- A Preliminary multicenter trial.New England Journal of Medicine, 322,365-372 p.

https://dx.doi.org/10.1056/NEJM198408093110604

Rosembloom AL, Sherman L. 1966.The Natural history of idiopathic hypoglycemia. New England Journal of Medicine.274, 815-820.

Slot C.1965.Plasma creatinine determination: a new and specific Jaffe reaction method .Scandinavian Journal of Clinical and Laboratory investigation 17, 381-387.

Tadashi T, Kengo F, Miho S, Akinori H, Yasunori I, Norahiko S. 2015. Relationship between serum uric acid levels and chronic kidney diseases in Japanese cohort with normal or mildly reduced kidney function              {ESMB}.

Trinder P.1969. Determination of glucose in blood using glucose oxidase with an alternative oxygen

acceptor. Annals of Clinical Biochemistry 6, 24.

Yuliang C, Hemei B, Shan L .2016. The relationship between serumuric acid and HbA1cis dependent upon hyperinsulinemia in patients with newly diagnosed type 2 diabetes mellitus. .Journal of Diabetes Research 71, 84123.

World Health Organization.2006. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: Report of the World  Health Organization and international Diabetes federation. Geneva Switzerland.

Ediale Joshua Richard, Adugba Oko Augustine, Celestine Okafor Ani, Paschal Uwadiegwu Chime, Uzoigwe Uzowulu Jide, Agu Uchenna Francis, Okorie Onyinye Pamela, Nworgu Choice Chinemerem, Adaobi Bisi Onyemaechi, Ebute Charles Paul.
Serum urea, uric acid and creatinine levels in diabetic mellitus patients attending Jos University Teaching Hospital, North central Nigeria.
Int. J. Biosci. 11(4), 68-72, October 2017.
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