International network for natural sciences – research journal
  • mendeley icon
  • linkedin icon
  • google plus icon
  • twitter icon
  • google scholar icon
  • facebook icon

Synthesis of silver nanoparticles from plant extracts and their antimicrobial application

By: Muhammad Ali Subhani, Nasira Wahab, Muhammad Ibrahim, Hameed Ur Rehman, Muhammad Asad, Wajid Ullah, Mohammad Kamil, Muhammad Ikramullah, Muhammad Arif, Muhammad Zubair, Wahid Shah, Malik Nawaz Shuja

Key Words: Silver Nanoparticles, Green synthesis, Antimicrobial.

Int. J. Biosci. 14(3), 243-257, March 2019.


Certification: ijb 2019 0015 [Generate Certificate]


Metallic nanoparticles are being used in each period of science alongside building counting medicinal and many other fields that fascinate the researchers to investigate new measurements for their individual worth which is by and large credited to their comparing little sizes. Among a few metal nanoparticles, silver nanoparticles have accomplished a unique core interest. Routinely silver nanoparticles are integrated by synthetic strategy utilizing synthetic compounds as lessening specialists which later wind up responsible for different natural dangers because of their general poisonous quality; inciting the genuine worry to create condition agreeable procedures. Therefore, to settle the goal; natural approaches are applied to fulfill the requirement; for example, green amalgamations utilizing natural particles gotten from plant sources as concentrates showing prevalence over synthetic as well as organic strategies. These plants based natural particles experience very controlled gathering for making them appropriate for the metal nanoparticle amalgamations. The present audit investigates the big variety of plant to be used towards fast and single step convention preliminary strategy with green standards over the traditional ones and depicts the antimicrobial exercises of silver nanoparticles.

| Views 26 |

Synthesis of silver nanoparticles from plant extracts and their antimicrobial application

Ahamed M, Khan MM, Siddiqui MKJ, AlSalhi MS, Alrokayan SA. 2011. Green synthesis, characterization and evaluation of biocompatibility of silver nanoparticles. Physica E: Low-dimensional Systems and Nanostructures 43(6), 1266-1271.

Alfuraydi AA, Devanesan S, Al-Ansari M, AlSalhi MS, Ranjitsingh AJ. 2019. Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities. Journal of Photochemistry and Photobiology B: Biology.

Ankanna ST, Elumalai EK, Savithramma N, 2010. Production of biogenic silver nanoparticles using Boswellia ovalifoliolata stem bark. Dig Journal Nanomater Biostructer 5(2), 369-372.

AshaRani PV, Low KM, Hande MP, Valiyaveettil S. 2008. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS nano 3(2), 279-290.

Ashokkumar S, Ravi S, Kathiravan V, Velmurugan S. 2015. RETRACTED: Synthesis of silver nanoparticles using A. indicum leaf extract and their antibacterial activity.

Baruwati B, Polshettiwar V, Varma RS. 2009. Glutathione promoted expeditious green synthesis of silver nanoparticles in water using microwaves. Green Chemistry 11(7), 926-930.

Chintamani RB, Salunkhe KS, Chavan MJ. 2018. Emerging use of green synthesis silver nanoparticle: an updated review. International journal of pharmaceutical sciences and research 9(10), 4029-4055.

Danai-Tambhale SD, Adhyapak PV. 2014. Facile green synthesis of silver nanoparticles using Psoralea corylifolia L. seed extract and their in-vitro antimicrobial activities. International Journal of Pharmacy BiologicalScience, 5, 457-467.

Dwivedi AD, Gopal K. 2010. Biosynthesis of silver and gold nanoparticles using Chenopodium album leaf extract. Colloids and Surfaces A: Physicochemical and Engineering Aspects 369(1-3), 27-33.

Eby DM, Schaeublin NM, Farrington KE, Hussain SM, Johnson GR. 2009. Lysozyme catalyzes the formation of antimicrobial silver nanoparticles. ACS nano 3(4), 984-994.

Elghanian R, Storhoff JJ, Mucic RC, Letsinger RL, Mirkin CA. 1997. Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. Science 277(5329), 1078-1081.

Ghosh SK, Kundu S, Mandal M, Pal T. 2002. Silver and gold nanocluster catalyzed reduction of methylene blue by arsine in a micellar medium. Langmuir 18(23), 8756-8760.

Gnanajobitha G, Paulkumar K, Vanaja M, Rajeshkumar S, Malarkodi C, Annadurai G, Kannan C. 2013. Fruit-mediated synthesis of silver nanoparticles using Vitis vinifera and evaluation of their antimicrobial efficacy. Journal of Nanostructure in Chemistry 3(1), 67.

Gopinath V, MubarakAli D, Priyadarshini S, Priyadharsshini NM, Thajuddin N, Velusamy P. 2012. Biosynthesis of silver nanoparticles from Tribulus terrestris and its antimicrobial activity: a novel biological approach. Colloids and Surfaces B: Biointerfaces 96, 69-74.

Govindaraju K, Tamilselvan S, Kiruthiga V, Singaravelu G. 2010. Biogenic silver nanoparticles by Solanum torvum and their promising antimicrobial activity. Journal of Biopesticides 3(1), 394.

Goyal RN, Oyama M, Bachheti N, Singh SP.  2009. Fullerene C60 modified gold electrode and Nano gold modified indium tin oxide electrode for prednisolone determination. Bio electrochemistry,  74(2), 272-277.

Haes AJ, Van Duyne RP. 2002. A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. Journal of the American Chemical Society 124(35), 10596-10604.

Iravani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B. 2014. Synthesis of silver nanoparticles: chemical, physical and biological methods. Research in pharmaceutical sciences 9(6), 385.

Jemal K, Sandeep BV, Pola S. 2017. Synthesis, characterization, and evaluation of the antibacterial activity of Allophylus serratus leaf and leaf derived callus extracts mediated silver nanoparticles. Journal of Nanomaterials.

Kalishwaralal K, Deepak V, Pandian SRK, Kottaisamy M, Barath MKS, Kartikeyan B,  Gurunathan S. 2010. Biosynthesis of silver and gold nanoparticles using Brevibacterium casei. Colloids and Surfaces B: Biointerfaces 77(2), 257-262.

Kaviya S, Santhanalakshmi J, Viswanathan B. 2011. Green synthesis of silver nanoparticles using Polyalthia longifolia leaf extract along with D-sorbitol: study of antibacterial activity. Journal of nanotechnology.

Kaviya S, Santhanalakshmi J, Viswanathan B, Muthumary J, Srinivasan K. 2011. Biosynthesis of silver nanoparticles using Citrus sinensis peel extract and its antibacterial activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 79(3), 594-598.

Kesharwani J, Yoon KY, Hwang J, Rai M, 2009. Phytofabrication of silver nanoparticles by leaf extract of Datura metel: hypothetical mechanism involved in synthesis. Journal of Bionanoscience 3(1), 39-44.

Khalil KA, Fouad H, Elsarnagawy T, Almajhdi FN. 2013. Preparation and characterization of electrospun PLGA/silver composite nanofibers for biomedical applications. International Journal of Electrochemical Science 8(3), 3483-3493.

Klaus-Joerger T, Joerger R, Olsson E, Granqvist CG. 2001. Bacteria as workers in the living factory: metal-accumulating bacteria and their potential for materials science. TRENDS in Biotechnology 19(1), 15-20.

Klueh U, Wagner V, Kelly S, Johnson A, Bryers JD. 2000. Efficacy of silver‐coated fabric to prevent bacterial colonization and subsequent device‐based biofilm formation. Journal of Biomedical Materials Research: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials 53(6), 621-631.

Kora AJ, Sashidhar RB. 2018. Biogenic silver nanoparticles synthesized with rhamnogalacturonan gum: Antibacterial activity, cytotoxicity and its mode of action. Arabian Journal of Chemistry 11(3), 313-323.

Korbekandi H, Iravani S. 2012. Silver  nanoparticles. In The delivery of nanoparticles. In Tech.

Krishnaraj C, Jagan EG, Rajasekar S, Selvakumar P, Kalaichelvan PT, Mohan N, 2010. Synthesis of silver nanoparticles using Acalypha indica leaf extracts and its antibacterial activity against water borne pathogens. Colloids and Surfaces B: Biointerfaces 76(1), 50-56.

Kulkarni N, Muddapur U. 2014. Biosynthesis of metal nanoparticles: a review. Journal of Nanotechnology.

Kumar PV, Pammi SVN, Kollu P, Satyanarayana KVV, Shameem U. 2014. Green synthesis and characterization of silver nanoparticles using Boerhaavia diffusa plant extract and their anti-bacterial activity. Industrial Crops and Products 52, 562-566.

Kumar SA, Daimary RM, Swargiary M, Brahma A, Kumar S, Singh M. 2013. Biosynthesis of silver nanoparticles using Premna herbacea leaf extract and evaluation of its antimicrobial activity against bacteria causing dysentery. International Journal of Pharmacy Biological Science 4(4), 378-84.

Kumarasamyraja D, Jeganathan NS. 2013. Green synthesis of silver nanoparticles using aqueous extract of acalypha indica and its antimicrobial activity. International Journal of Pharmacy Biological Science 4(3), 469-476.

Lakshmanan G, Sathiyaseelan A, Kalaichelvan PT, Murugesan K. 2018. Plant-mediated synthesis of silver nanoparticles using fruit extract of Cleome viscosa L.: Assessment of their antibacterial and anticancer activity. Karbala International Journal of Modern Science 4(1), 61-68.

Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L,  Rodriguez-Padilla C. 2010. Mode of antiviral action of silver nanoparticles against HIV-1. Journal of nanobiotechnology 8(1), 1.

Larguinho M, Baptista PV. 2012. Gold and silver nanoparticles for clinical diagnostics—from genomics to proteomics. Journal of proteomics 75(10), 2811-2823.

Maity TR, Samanta A, Saha B, Datta S. 2019. Evaluation of Piper betle mediated silver nanoparticle in post-harvest physiology in relation to vase life of cut spike of Gladiolus. Bulletin of the National Research Centre 43(1), 9.

Masurkar SA, Chaudhari PR, Shidore VB, Kamble SP. 2011. Rapid biosynthesis of silver nanoparticles using Cymbopogan citratus (lemongrass) and its antimicrobial activity. Nano-micro letters 3(3), 189-194.

Mozumder MS, Mourad AH, Pervez H, Surkatti R. 2019. Recent developments in multifunctional coatings for solar panel applications: A review. Solar Energy Materials and Solar Cells 189, 75-102.

Nabikhan A, Kandasamy K, Raj A, Alikunhi NM. 2010. Synthesis of antimicrobial silver nanoparticles by callus and leaf extracts from saltmarsh plant, Sesuvium portulacastrum L. Colloids and surfaces B: Biointerfaces, 79(2), 488-493.

Nakkala JR, Mata R, Gupta AK, Sadras SR. 2014. Biological activities of green silver nanoparticles synthesized with Acorous calamus rhizome extract. European journal of medicinal chemistry 85, 784-794.

Park J, Lim DH, Lim HJ, Kwon T, Choi JS, Jeong S, Cheon J. 2011. Size dependent macrophage responses and toxicological effects of Ag nanoparticles. Chemical communications 47(15), 4382-4384.

Pattanayak M, Nayak PL. 2013. Green synthesis and characterization of zero valent iron nanoparticles from the leaf extract of Azadirachta indica (Neem). World Journal of Nanomaterial Science Technology 2(1), 06-09.

Prabhu S, Poulose EK. 2012. Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects.  International nano letters 2(1), 32.

Qiao Z, Yao Y, Song S, Yin M, Luo J. 2019. Silver nanoparticles with pH induced surface charge switchable properties for antibacterial and antibiofilm applications. Journal of Materials Chemistry B, 7(5), 830-840.

Rai M, Yadav A, Gade A. 2009. Silver nanoparticles as a new generation of antimicrobials. Biotechnology advances 27(1), 76-83.

Rajeshkumar S, Bharath LV. 2017. Mechanism of plant-mediated synthesis of silver nanoparticles–a review on biomolecules involved, characterisation and antibacterial activity. Chemico-biological interactions 273, 219-227.

Ramya M, Subapriya MS, 2012. Green synthesis of silver nanoparticles. International Journal of Pharmaceutical Medical Biological Science 1(1), 54-61.

Reddy GAK, Joy JM, Mitra T, Shabnam S, Shilpa T. 2012. Nano silver – a review. International Journal of Advance Pharmacy 2(1), 09–15s

Rout A, Jena PK, Parida UK, Bindhani BK. 2013. Green synthesis of silver nanoparticles using leaves extract of Centella asiatica L. For studies against human pathogens. International Journal of Pharmaceutical Biological Science 4(4), 661-74.

Sadeghi B, Gholamhoseinpoor F. 2015. A study on the stability and green synthesis of silver nanoparticles using Ziziphora tenuior (Zt) extract at room temperature. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 134, 310-31.

Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. 2009. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environmental health perspectives 118(3), 407-413.

Santhoshkumar T, Rahuman AA, Rajakumar G, Marimuthu S, Bagavan A, Jayaseelan C, Kamaraj C. 2011. Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors. Parasitology research 108(3), 693-702.

Sharma VK, Yngard RA, Lin Y. 2009. Silver nanoparticles: green synthesis and their antimicrobial activities. Advances in colloid and interface science 145(1-2), 83-96.

Singh A, Jain D, Upadhyay MK, Khandelwal N, Verma HN. 2010. Green synthesis of silver nanoparticles using Argemone mexicana leaf extract and evaluation of their antimicrobial activities. Journal of Nanomaterial Biosciences 5(2), 483-489.

Sintubin L, De Gusseme B, Van der Meeren P, Pycke BF, Verstraete W, Boon N. 2011. The antibacterial activity of biogenic silver and its mode of action. Applied microbiology and biotechnology 91(1), 153-162.

Sondi I, Salopek-Sondi B. 2004. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Journal of colloid and interface science 275(1), 177-182.

Sun S, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li G. 2004. Monodisperse mfe2o4 (m= fe, co, mn) nanoparticles. Journal of the American Chemical Society 126(1), 273-279.

Syed A, Ahmad A. 2012. Extracellular biosynthesis  of platinum nanoparticles using the fungus Fusarium oxysporum. Colloids and Surfaces B: Biointerfaces 97, 27-31.

Ulug B, Turkdemir MH, Cicek A, Mete A. 2015. Role of irradiation in the green synthesis of silver nanoparticles mediated by fig (Ficus carica) leaf extract. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 135, 153-161.

Veerasamy R, Xin TZ, Gunasagaran S, Xiang TFW, Yang EF, Jeyakumar N, Dhanaraj SA. 2011. Biosynthesis of silver nanoparticles using mangosteen leaf extract and evaluation of their antimicrobial activities. Journal of Saudi Chemical Society 15(2), 113-120.

Vijayaraghavan K, Nalini SK, Prakash NU, Madhankumar D. 2012. One step green synthesis of silver nano/microparticles using extracts of Trachyspermum ammi and Papaver somniferum. Colloids and Surfaces B: Biointerfaces 94, 114-117.

Wright JB, Lam K, Hansen D, Burrell RE, 1999. Efficacy of topical silver against fungal burn wound pathogens. American journal of infection control 27(4), 344-350.

Yakabe Y, Sano T, Ushio H, Yasunaga T. 1980. Kinetic studies of the interaction between silver ion and deoxyribonucleic acid. Chemistry Letters 9(4), 373-376.

Yu H, Chen M, Rice PM, Wang SX, White RL, Sun S. 2005. Dumbbell-like bifunctional Au− Fe3O4 nanoparticles. Nano letters 5(2), 379-382.

Zhang Y, Yang D, Kong Y, Wang X, Pandoli O, Gao G. 2010. Synergetic antibacterial effects of silver nanoparticles@ aloe vera prepared via a green method. Nano Biomedicine and Engineering 2(4), 252-257.

Muhammad Ali Subhani, Nasira Wahab, Muhammad Ibrahim, Hameed Ur Rehman, Muhammad Asad, Wajid Ullah, Mohammad Kamil, Muhammad Ikramullah, Muhammad Arif, Muhammad Zubair, Wahid Shah, Malik Nawaz Shuja.
Synthesis of silver nanoparticles from plant extracts and their antimicrobial application.
Int. J. Biosci. 14(3), 243-257, March 2019.
Copyright © 2019
By Authors and International Network for
Natural Sciences (INNSPUB)
innspub logo
english language editing
    Publish Your Article
    Submit Your Article
Email Update