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High histological grade breast cancer morphological evaluation on mammogram using the box-counting fractal dimension

By: Bonou Malomon Aimé, Hounsossou Cocou Hubert, Ayinon Epiphane, Helou Kossi Armel, Dossou Julien, Biaou Olivier

Key Words: Fractal dimension, Box-counting, High grade breast cancer, Mammogram

Int. J. Biomol. & Biomed. 11(1), 15-20, August 2020.

Certification: ijbb 2020 0010 [Generate Certificate]

Abstract

To evaluate the high-grade breast cancer morphological complexity on mammogram. We conducted a retrospective study using an open source data got from figshare repository. These anonymized data were collected and used for a study approved by the institutional review board. Cranio-Caudal and Medio-lateral mammograms and their tumor segmented images from 66 patients subdivided in two groups high histological grade (n=23) low-grade (low and intermediate, n=41). From breast cancer image segmentation, we extracted fractal dimension using Fraclac, plugin of ImageJ software based on box-counting method. For our analysis we used comparatively the fractal dimension from cranio-caudal (CC) and medio-lateral (MLO) images. We summarized the fractal dimension of our cohort using boxplot and performed the Wilcoxon non-parametric statistic for fractal dimension comparison of two groups (High-grade and low-grade). There was not difference between CC (mean ± std= 1.1583±0.067) andmLO (mean ± std =1.1551±0.055) breast cancer fractal dimension. For the high-grade differentiation, CC andmLO images fractal dimension were contributed respectively at a little difference but without statistically difference (P value=0.438 and 0.435). High-grade fractal dimensions mean were respectively 1.142±0.044 and 1.144±0.075 for CC andmLO images against 1.166±0.050 and 1.160±0.057 for low-grade. It had been recorded a lower mean value of fractal dimension for high-grade breast cancer without statistically significant. This finding shows that the high-grade breast cancer tends to have a regular shape.

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High histological grade breast cancer morphological evaluation on mammogram using the box-counting fractal dimension

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Bonou Malomon Aimé, Hounsossou Cocou Hubert, Ayinon Epiphane, Helou Kossi Armel, Dossou Julien, Biaou Olivier.
High histological grade breast cancer morphological evaluation on mammogram using the box-counting fractal dimension.
Int. J. Biomol. & Biomed. 11(1), 15-20, August 2020.
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