Prediction of Tertiary Structure Homology between Bactericidal/Permeability Increasing Protein of Innate Immune System and Hydrolase Enzymes
Paper Details
Prediction of Tertiary Structure Homology between Bactericidal/Permeability Increasing Protein of Innate Immune System and Hydrolase Enzymes
Abstract
Bactericidal/permeability increasing protein (BPI) is known as the important arm of the innate immune system that provides the first line of defense against various gram-negative bacterial infections in mammalians. The critical aspect of the antibacterial action of BPI against these bacteria is the binding of BPI to the envelope lipopolysaccharides (LPS). However, there is very rare information about the molecular events following the interaction between BPI and bacterial compounds. As the first ever time report, by using the available bioinformatics and computational tools, BPI protein family was predicted to be structurally and functionally comparable to lipolytic hydrolases particularly including esterase-lipases. This computational identification helped us to propose a potential mode of action for BPI family in mammalian immune system, opposing to the LPS hydrolysis by bacterial phospholipases.
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