Exercise-induced weigh loss in the absence of a control diet does not affect serum resistin or insulin resistance in obese males

Paper Details

Research Paper 01/04/2011
Views (316) Download (6)
current_issue_feature_image
publication_file

Exercise-induced weigh loss in the absence of a control diet does not affect serum resistin or insulin resistance in obese males

Eizadi Mojtaba, Ahmadi Pezhman, Nasiri Farsani Mokhtar, Torabi Mohsen
Int. J. Biosci.1( 2), 58-66, April 2011.
Certificate: IJB 2011 [Generate Certificate]

Abstract

To investigate effect a merely long time aerobic exercise program in the absence of a control diet on serum resistin and insulin resistance in obese males. A total thirty obese males aged 35 +/- 6 yr were randomly allocated into exercise and control groups. Serum resistin, insulin and glucose were measured after overnight fast before and after a supervised aerobic exercise for 3 month (3 sessions weekly) in exercise group or detraining in control group. Anthropometric assessments also were done in these conditions. Insulin resistance (HOMA-IR) was calculated using fasting insulin and glucose. Statistical analysis was performed using an independent paired t-test. A p-value < 0.05 was considered to be statistically significant. Despite all anthropometrical indexes and body weight were significantly decreased by aerobic exercise program training in exercise group (p<0.05), but serum resistin and insulin resistance remained without change (p≥0.05). All variables remained without change in control group (p≥ 0.05). Based on this data, it was concluded that exercise program in the absence of a control diet does not affect circulation resistin or insulin resistance in obese subjects.

VIEWS 7

Anderlová K, Kremen J, Dolezalová R, Housová J, Haluzíková D, Kunesová M. 2006. The influence of very-low-calorie-diet on serum leptin, soluble leptin receptor, adiponectin and resistin levels in obese women. : Physiol Res 55(3), 277-83.

Athyros V, Tziomalos K, Karagiannis A, Anagnostis P, Mikhailidis D. 2010. Should adipokines be considered in the choice of the treatment of obesity-related health problems? Current Drug Targets 11(1), 122-35.

Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H. 2006. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17(1), 4-12.

Hivert MF, Sullivan LM, Fox CS, Nathan DM, D’Agostino RB Sr, Wilson PW. 2008. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Metab 93(8), 3165-72.

Jung SH, Park HS, Kim KS, Choi WH, Ahn CW, Kim BT. 2008. Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. J Nutr Biochem 19(6), 371-5.

Kadoglou N, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. 2007. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care 30(3), 719-21.

Kelly AS, Steinberger J, Olson TP, Dengel DR. 2007. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 56(7), 1005-9.

Kim KH, Lee K, Moon YS, Sul HK. 2001. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276(14), 11252-6.

Koebnick C, Wagner K, Garcia AL, Gruendel S, Lahmann PH, Weickert MO. 2006. Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism. Int J Obes (Lond) 30(7), 1097-103.

Kopff B, Jegier A. 2005. Adipokines: adiponectin, leptin, resistin and coronary heart disease risk. Przegl Lek 62 (Suppl 3), 69-72.

Marcell TJ, McAuley KA, Traustadóttir T, Reaven PD. 2005. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 54(4), 533-41.

Marita AR, Sarkar JA, Rane S. 2005. Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: Study from Mumbai, Western India. Molecular and Cellular Biochemistry 275, 143–151.

Meier U, Gressner AM. 2004. Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin. Clin Chem 50(9), 1511-25.

Moschen AR, Molnar C, Geiger S, Graziadei I, Ebenbichler CF, Weiss H. 2010. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor {alpha} expression. Gut [Epub ahead of print].

Park S, Hong SM, Sung SR, Jung HK. 2008. Long-Term Effects of Central Leptin and Resistin on Body Weight, Insulin Resistance, and ß-Cell Function and Mass by the Modulation of Hypothalamic Leptin and Insulin Signaling. Endocrinology 149(2), 445-54.

Reilly M, Lehrke M, Wolfe M, Rohatgi A, Lazar M, Rader D. 2005. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111(7), 932-9.

Reinehr T, Roth CL, Menke T, Andler W. 2006. Resistin concentrations before and after weight loss in obese children. Int J Obes (Lond) 30(2), 297-301.

Stejskal D, Adamovská S, Bartek J, Juráková R, Prosková J. 2003. Resistin – concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147(1), 63-9.

Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee R, Wright CM. 2001. The hormone resistin links obesity to diabetes. Nature 409, 307-12.

Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S. 2005. Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia 48(11), 2330-3.

Valsamakis G, McTernan PG, Chetty R, Al Daghri N, Field A, Hanif W, Barnett AH. 2004. Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines. Metabolism 53(4), 430-4.

Weikert C, Westphal S, Berger K, Dierkes J, Mohlig M, Spranger J. 2008. Plasma resistin levels and risk of myocardial infarction and ischemic stroke. J Clin Endocrinol Metab 93(7), 2647-53.

Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS. 2004. Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol (Oxf) 61(3), 332-8.

Zou CC, Liang L, Hong F. 2007. Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity. Indian Pediatr 44(4), 275-9.