home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Acute administration of aqueous extract of Garcinia kola on daily blood glucose level and selected biochemical indices in longevity wistar albino rats

Paper Details

Research Paper 01/12/2013
Views (393) Download (20)
current_issue_feature_image
publication_file

Acute administration of aqueous extract of Garcinia kola on daily blood glucose level and selected biochemical indices in longevity wistar albino rats

Imo Chinedu, Friday O. Uhegbu, Imo Chukwuechefulam K., Ifeanacho Nkeiruka G., Osuocha Kelech U., Ibe Chibuike
Int. J. Micro. Myco.1( 2), 7-12, December 2013.
Certificate: IJMM 2013 [Generate Certificate]
Key: Blood glucoseGarcinia kolaLiver enzymes and life expectancy

Abstract

This study evaluated the effects of acute administration of aqueous extract of Garcinia kola on daily blood glucose level and selected biochemical indices in wistar albino Rats in connection with human health. The serum liver enzymes ALT and ALP increased significantly (p<0.05) in the test animals in groups two and three, while AST also increased, though not significantly (p<0.05). ALT increased from 35.38 ± 1.35 U/L in control group (group one) to 47.25 ± 1.71 U/L in group three, while AST and ALP increased from 36.75 ± 2.50 U/L to 38.25 ± 4.79 U/L and 27.46 ± 4.57 U/L to 40.14 ± 7.26 U/L respectively. Blood glucose level decreased on daily basis after administration of aqueous extract of Garcinia kola. The results showed that daily consumption of Garcinia kola induced hypoglycaemic effect and hepatic damage in Wistar albino rats as observed in groups two and three. This invariably implies that the longevity of human beings is guaranteed if adequately consumed and life expectancy in Nigeria positively influenced.

VIEWS 21
Cover PDF

Adaramoye OA, Adeyemi O. 2006. Hypoglycaemic and hypolipidaemic effects of fractions  from  kolaviron,  a  biflavonoid  complex from Garcinia kola in streptozotocin induced diabetes mellitus rats. Journal of Pharmacy and Pharmacology 58, 121-128.

Adaramoye OA, Nwaneri VO, Anyanwu KC, Farombi EO, Emerole GO. 2005. Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clinical and Experimental Pharmacology and Physiology 32(1-2), 40-46.

Adesuyi AO, Elumm IK, Adaramola FB, Nwokocha AGM. 2012. Nutritional and Phytochemical Screening of Garcinia kola. Journal of Food Science and Technology 4(1), 9–14.

Esimone CO, Adiukwu MU, Nworu CS, Okoye FBC, Odimegwu DC. 2007. Adaptogenic potentials of Camellia sinensis leaves, Garcinia kolaand Kola nitida seeds. Scientific Research and Essay 2(7), 232–237.

Lamba SS, Buch KY, Lewis H, Lamba L. 2000. Phytochemicals as potential hypoglycemic agents. Studies in Natural Product Chemistry 21(2), 457– 496.

Marrif HI, Ali BH, Hassan KM. 1995. Pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice. Journal of Ethnopharmacology 49, 51–55.

Moore M, Thor H, Moore G, Nelson S, Moldeus P, Orrenius S. 1985. The toxicity of acetaminophen and N-acetyl p-benzoquinoneimine in isolated hepatocytes is associated with the depletion and increased cystosolic Ca2+. Journal of Biological Chemistry 260, 13035-13040.

Njume C, Afolayan AJ, Clarke AM, Ndip RN. 2011. Crude Ethanolic Extracts of Garcinia kola Seeds Heckel (Guttiferae) Prolong the Lag Phase of Helicobacter pylori: Inhibitory and Bactericidal Potential. Journal of Medicinal Food 14(7-8), 822-827.

Olajide OJ, Adeniyi PA. 2011. Studies on effects of aqueous Garcinia kola extract on the lateral geniculate body and rostral colliculus of adult Wistar rats. Medical Practice and Reviews 2 (2), 23–28.

Rajan M, Kumar VK, Kumar PS, Thiravenkatesubramaniyam R, Nkumar NS. 2010. Antidiabetic activity of ethanolic extract on Albizia odoratissima (L.F) Benth in alloxan induced diabetic Rats. International Journal of Pharmaceutical Sciences 2 (3), 786–791.

Reitman S, Frankel S.  1957.  Transaminases. American Journal of Clinical Pathology 28, 56.

Tietz NW, Burtis CA, Duncan P, Ervin K, Petitclerc CJ, Rinker AD, Shuey D, Zygowicz ER. 1983. A reference method for measurement of alkaline phosphatase activity in human serum. Clinical Chemistry 3(29), 751-761

Submit Manuscript