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Anti-diabetic effect of Ceylon cinnamon aqueous extract against blood glucose, lipid profile and hematological parameters in male diabetic rats

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Research Paper 01/12/2018
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Anti-diabetic effect of Ceylon cinnamon aqueous extract against blood glucose, lipid profile and hematological parameters in male diabetic rats

Asia Parveen, Khan Arbaz Ali, Muhammad Maisam, Nureen Zahra, Rabail Alam, Modasrah Mazhar, Ayesha shaukat
Int. J. Biosci.13( 6), 169-175, December 2018.
Certificate: IJB 2018 [Generate Certificate]
Key: AlloxanAntilipidemicCinnamon extractHematological indicesHypoglycemic

Abstract

Diabetes mellitus is a multifactorial endocrine pathology appears mainly with hyperglycemia and disturbed lipid profile. Cinnamon is well known in Asian and Middle East countries for their antidiabetic activity. Main objective was the evaluation of antidiabetic spice cinnamon on diabetes mellitus in terms of blood glucose, lipid profile and hematological parameters. Male albino rats (Rattus norvegicus) ageing 10 – 12 weeks and weighting 163-170g were made diabetic with alloxan via intra-peritoneal injection.Rats were divided into four groups each group consist of three rats. Group A is control group, Group B served as negative or diabetic group. Group C Served as cinnamon treated group with 500 mg/kg body of weight of cinnamon extract, Group D served as positive group treated with secretagogue glimepiride. During 14 days of research rats were daily medicated via orally. At the end of study starved rats were anesthetized and dissected for the collection of blood samples. Blood glucose significantly (P<0.005) reduced in cinnamon extract treated rats after 7 and 14 days of treatment as compare to diabetic rats. Total cholesterol, triglycerides and low density lipoproteins also significantly (P<0.05) reduced in cinnamon extract treated group. While hematological parameters total erythrocyte count (TLC) and hemoglobin (HB) were only improved insignificantly in Group C. Cinnamon has significant hypoglycemic and antilipidemic effects to cure diabetes and diabetes induced dyslipidemia. Cinnamon extract has no toxic effects on hematological parameters. Further studies are required to evaluate the mode of action and longtime toxicity effects of extract on kidney and liver.

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