home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Hormonal disorders changes in women suffering from polycystic ovary syndrome

Paper Details

Research Paper 01/04/2019
Views (321) Download (10)
current_issue_feature_image
publication_file

Hormonal disorders changes in women suffering from polycystic ovary syndrome

Dalal F. Muhsin, Faris S. Kata, Edwar Z. Khosho
Int. J. Biosci.14( 4), 248-254, April 2019.
Certificate: IJB 2019 [Generate Certificate]
Key: CortisolInsulinPCOSPolycystic ovary syndromeTestosterone

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in reproductive age women around the world and it is identified as hyperandrogenism and chronic anovulation disorder. Because of the great number of women infected by PCOS in Iraq and in Basrah governorate in particular, and due to the increased rates of infertility and miscarriage cases related to PCOS, the current study has been designed to highlight some of the causes of PCOS through the changes in hormonal parameters. This study was done in basrah governorate since May, 2018 until November, 2018, serum samples were collected from (75) PCOS patients and (75) healthy women as control during the luteal phase of the menstrual cycle. Then the consentrations of (estradiol and progesteroneprolactin, testosterone, LH, TSH,T3,insulin ,cortisol, FSH and T4) hormones were measured by using specific ELIZA kits. The results of our study showed that estradiol and progesterone were significantly decreased in PCOS patients than control group (P<0.05), while prolactin, testosterone, LH, TSH, T3, insulin and cortisol were significantly increased in PCOS patients than control group (P<0.05), but our results showed no differences in the levels of serum FSH and T4 hormones between PCOS patients and controls group (P>0.05). In conclusion, the hormonal abnormalities are a characteristic trait in PCOS patients comparing with healthy women with normal hormones and this differences may be play an key role in the origins of PCOS in Basrah women and gives an overview about the causes of the prevalence of this disorder among these women.

VIEWS 12
Cover PDF

Abbott DH, Vepraskas SH, Horton TH, Terasawa E and Levine JE. 2018. Accelerated Episodic Luteinizing Hormone Release Accompanies Blunted Progesterone Regulation in PCOS-like Female Rhesus Monkeys (Macaca Mulatta) Exposed to Testosterone during Early-to-Mid Gestation. Neuroendocrinolology 107, 133-146.

Agardh EE, Ahlbom A, Andersson T, Efendic S, Grill V, Hallqvist J, Ostenson CG. 2003. Work stress and low sense of coherence is associated with type 2 diabetes in middle-aged Swedish women.Diabetes care 26, 719-724.‏

Als-Nielsen B, Koretz, RL, Kjaergard, LL, Gluud C. 2003. Branched-chain amino acids for hepatic encephalopathy. Cochrane Database of Systematic Reviews.

Apparao KB, Lovely LP, Gui Y, Lininger RA, Lessey BA. 2008. Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biology of Reproduction 66, 297-304.

Azziz R, Dumesic DA, Goodarzi MO. 2011.Polycystic ovary syndrome: an ancient disorder?. Fertility and sterility 95, 1544-1548.

Banaszewska B, Spaczynski RZ, Pelesz M, Pawelczyk L. 2003. Incidence of elevated LH/FSH ratio in polycystic ovary syndrome women with normo-and hyperinsulinemia. Roczniki Akademii Medycznej w Bialymstoku 48, 131-134.

Barnes FL, Kausche A, Tiglias J, Wood C, Wilton L, Trounson A. 1996. Production of embryos from in vitro-matured primary human oocytes. Fertility and sterility 65, 1151-1156.

Carmina E, Lobo RA. 1999.Polycystic ovary syndrome (PCOS, Arguably the most common endocrinopathy is associated with significant morbidity in women. The Journal of Clinical Endocrinology and Metabolism 84, 1897-1899.

Carmina E. 2004. Diagnosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines. Minerva Ginecologica 56, 1-6.

Chang RJ, Heindel J, Dunaif A. 2002. Polycysticovary syndrome. New York, Marcel Dekker Inc 1-14.

Charalampakis V, Tahrani AA, Helmy A, Gupta JK and Singh R. 2016. Polycystic ovary syndrome and endometrial hyperplasia: an overview of the role of bariatric surgery in female fertility. The European Journal of Obstetrics and Gynecology and Reproductive Biology 207, 220-226.

Chaudhary N, Qamar I. 2016. Polycystic Ovary Syndrome: Conditions. Genetics and Current Cure. The Journal of Clinical Endocrinology and Metabolism 3, 2-7.

Chen L, Tan Y, Cao P. 2017. Relationship of thyroid stimulating hormone with sex hormones in patients with polycystic ovary syndrome: a single-center, retrospective observational study.InternationalJournal of Clinical and Experimental Pathology 10, 5989-5993.

Chen Z, Shi Y. 2010. Polycystic ovary syndrome. Frontiers of medicine in China 4, 280-284.

Comim FV, Teerds K, Hardy K, Franks S. 2013. Increased protein expression of LHCG receptor and 17α-hydroxylase/17-20-lyase inhuman polycystic ovaries. Human Reproduction 28, 3086-3092.

Dewailly D. 2009. Definition of polycystic ovary syndrome. Human Fertility 3, 73-76.

Dumitrescu R, Mehedintu C, Briceag I, Purcarea VL, Hudita D. 2015. The Polycystic Ovary Syndrome: An update on metabolic and hormonal mechanisms. Journal of Medicine and Life 8, 142-145.

Ehrman DA, Barnes RB, Rosenfield RL. 1995. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocrine Reviews 16, 322-353.

Franks S, McCarthy MI, Hardy K. 2006. Development of polycystic ovary syndrome: involvement of genetic and environmental factors. International Journal of Andrology 29, 278-285.

Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E. 2015. American association of clinical endocrinologists, american college of endocrinology and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome – part 1.Endocrine Practice 21, 1415-26.

‏Guyton AC, Hall JE. 2006. Textbook of Medical Physiology. 11th Edition, Elsevier Saunders, Amsterdam.

Hague WM, Millar DR. 1985.Excessive testosterone secretion in pregnancy. Case report. British Journal of Obstetrics and Gynaecology 92, 173-178.

Harris HR, Babic A, Webb, PM, Nagle, CM, Jordan SJ, Risch HA, Ness RB. 2018. Polycystic ovary syndrome, oligomenorrhea, and risk of ovarian cancer histotypes: Evidence from the Ovarian Cancer Association Consortium. Cancer Epidemiology and Prevention Biomarkers 27, 174-182.‏

Homburg R, Ray A, Bhide P, Gudi A, Shah A, Timms P, Grayson K. 2013. The relationship of serum anti-Mullerian hormone with polycystic ovarian morphology and polycystic ovary syndrome: a prospective cohort study, Human Reproduction 28, 1077-1083.

Jha SK, Kannan S. 2016.Serum prolactin in patients with liver disease in comparison with healthy adults: A preliminary cross-sectional study.International Journal of Applied and Basic Medical Research 6, 8-10.‏

Jones MR, Brower MA, Xu. N, Cui J, Mengesha E, Chen YDI, Goodarzi MO. 2015. Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity. PLoS genetics11, e1005455.‏

Karagiannis A, Harsoulis F. 2005.Gonadal dysfunction in systemic diseases. European Society of Endocrinology 152, 501-13.

Knisley E. 2018. Polycystic Ovarian Syndrome. Master of Science in Nursing, Student Scholarship 327.

Lobo RA. 1995. A disorder without identity “HCA,” “PCO,” “PCOD,” “PCOS,” “SLS.” What are we to call it?. Fertility and Sterility 63, 1158-60.

Mccance KL, Huether SE, Brashers VL, Rote NS. 2010.Pathophysiology: The Biologic Basics for Disease in Adults and Children.United States of America. Mosby Elsevier, 824-826.

Padalkar RK, Patil SM, Andure DV, Bhagat SS, Raut AM. 2017. Study of Hormone and Lipid Profile in Polycystic Ovarian Syndrome Women between the Age 18 to 30 Years. Journal of Practical Biochemistry and Biophysics 2, 11-15.

Pasquali R. 2018. Lifestyle Interventions and Natural and Assisted Reproduction in Patients with PCOS. In Infertility in Women with Polycystic Ovary Syndrome .Springer, Cham 169-180.

Qi J, Wang W, ZhuQ, HeY, Lu Y, Wang Y, Li X, Chen Z, Sun Y. 2018. Local Cortisol Elevation Contributes to Endometrial Insulin Resistance in Polycystic Ovary Syndrome. The Journal of Clinical Endocrinology and Metabolism 103, 2457-2467.

Sembulingam K, Sembulingam P. 2012. Essential medical physiology. 6th Edition, Jaypee Brothers Medical Publishers, India.

Singh S, Ravichandran R, Panda PK. 2018. The enigma of PCOS. Journal of RNA Genomics 14, 610-614.

Spritzer PM. 2014. Polycystic ovary syndrome: reviewing diagnosis and management of metabolic disturbances. Arquivos Brasileiros de Endocrinologia and Metabologia 58, 182-187.

Tsilchorozidou T, Honour JW, Conway GS. 2003. Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5α-reduction but not the elevated adrenal steroid production rates. The Journal of Clinical Endocrinology and Metabolism 88, 5907-5913.

Velissaris D, Karanikolas M, Kalogeropoulos A, Solomou E, Polychronopoulos  P, Thomopoulos K. 2008. Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic Encephalopathy. The World Journalof Gastroenterology 14, 4190-4195.

Yin D, Ruan X, Tian X, Du J, Zhao Y, Cui Y, Mueck AO. 2017. The relationship between thyroid function and metabolic changes in Chinese women with polycystic ovary syndrome. Gynecological Endocrinology 33, 332-335.

Submit Manuscript