Relationship between obesity and thyriod hormone level in human body

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Research Paper 01/01/2019
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Relationship between obesity and thyriod hormone level in human body

Muhammad Muzammal, Safeer Ahmad, Muhammad Zeeshan Ali, Muhammad Ikram, ToqeerAhmad, Sohail Ahmad, Rizwan, Saima Mashal, Amna Karim, Fatima, Sana Saleem Jan
Int. J. Biosci. 14(1), 70-74, January 2019.
Copyright Statement: Copyright 2019; The Author(s).
License: CC BY-NC 4.0

Abstract

Thyroid gland is the largest and purest endocrine gland in the body about 20gm in weight. It secretes two types of hormones Thyroxine (T4) and Triiodothyronine (T3). These two hormones are involved in the basic metabolic process in the body. Due to malnutrients our youth is facing many problems related to health. This study was done on the normal and obese individuals to find out the level of thyroid hormone in their body that either obesity has any effect on the thyroid hormone level in the body. Using standard method the BMI of all the individuals was calculated. Also the level of Thyriod hormone was calculated using Elisa technique. In our finding highest level of TSH in male participants was found to be 2.672μIU/ml and his BMI was 32.196, while he had low level of T3 and T4 hormone i.e. 0.971ng/ml and 5.683μg/dl respectively. In Female participants highest level of TSH was found to be 2.875μIU/ml.Her BMI was 32.87 and her T3 and T4 hormone level was 1.019ng/ml and 5.621μg/dl respectively, Which was significantly lesser then the rest of the female participants with normal BMI. Our study strongly relates to the hypothesis that obese individuals has high level of TSH while low level of T3 and T4 hormone as compared to the normal individuals. So our study suggest that for normal level and functioning of hormones in the body, foucs on your diet and avoid malnutreints, so your body weigth remains normal as such your hormonal level.

Braverman LE, Utigen RD, Eds. Werner Ingbar’s. 1996. ‘The Thyroid – A Fundamental and Clinical Text’7th Ed. Philadelphia. Lippinscott –Raven.

Brent GA. 2012. Mechanisms of thyroid hormone action. J Clin Invest 122, 3035–43.

Hajer GR, Van Haeften TW, Visseren FL. 2008.Adipose tissue dysfunction in obesity, diabetes, and vascular diseases Eur Heart J, 29, 2959-71.

Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ. 2001. “Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability.”. Endocrine Reviews 22(4), 451–476.

Kansagra Shayri M, McCudden Christopher R, Willis, Monte S. 2010. “The Challenges and Complexities of Thyroid Hormone Replacement”. Laboratory Medicine 41(6), 338–348.

Kozak D, Springer-Riddle J. 2000.Foolproof Weight Loss. Rodale.

Lobo JC, Torres JP, Fouque D, Mafra D. 2010. Zinc deficiency in chronic kidney disease: is there a relationship with adipose tissue and atherosclerosis? Biol Trace Elem Res. 135, 16–21.

Morris MJ, Beilharz JE, Maniam J, Reichelt AC, Westbrook RF. 2015.Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition. Neurosci. Biobehav 58, 36–45.

Muzzaffari EL, Gharib H. 1998.Thyroxine suppressive therapy in patients with nodular thyroid disease”.Ann Inter Med. 128, 386-394.

Park, Yong-Woo, Shankuan Zhu, Latha Palaniappan, Stanley Heshka, Mercedes R. Carnethon, Steven B. Heymsfield. 2003. “The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population from the Third National Health and Nutrition Examination Survey, 1988–1994.” Archives of Internal Medicine 163, 427–36.

Spencer CA. 1995 Interlaboratory / Intermethod differences in Functional Sensitivity of Immunometric Assays of Thyrotropin (TSH) and Impact on Reliability of Measurement of Subnormal Concentration of TSH. Clinical Chemistry 41, 367.

Stipanuk MH. 2000. Biochemical and Physiological Aspects of human nutrition. Saunders, Philadelphia. 763-775.

Van Kruijsdijk RC, Van der Wall E, Visseren FL. 2009. Obesity and cancer: the role of dysfunctional adipose tissue Cancer Epidemiol Biomarkers Prev 18, 2569-78

Wass John AH, Stewart Paul M. 2011. Oxford Textbook of Endocrinology and Diabetes (2nd ed.). Oxford: Oxford University Press, p 565.

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