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The Protective Role Of Panax ginseng On Hepatotoxicity Induced By Carbon Tetrachloride In Male Rats

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Research Paper 08/05/2023
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The Protective Role Of Panax ginseng On Hepatotoxicity Induced By Carbon Tetrachloride In Male Rats

Abdallah M. Sliai
Int. J. Biosci.22( 5), 96-102, May 2023.
Certificate: IJB 2023 [Generate Certificate]
Key: Carbon tetrachlorideHistomorphometryHistopathologyLiverPanax ginseng

Abstract

The present study aimed to investigate the possible protective effects of Panax ginseng C. A. MEYER (Araliaceae) on liver damage caused by carbon tetrachloride in rats. The histopathological changes and certain liver enzymes were investigated. The results showed that carbon tetrachloride causes elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels production of the liver and decreased nuclear area and nuclear volume in the liver of CCl4-treated rats. Histopathological observations indicated severe damage in the liver. Panax ginseng co-treatment to the CCl4-administered rats attenuated the increase of the liver enzymes and restored the mean values of the nuclear area and nuclear volume and the morphological damage in the liver was reduced. It is therefore suggested that the Panax ginseng can provide a protective effect against acute hepatic injury caused by CCl4 in rats.

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