home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

The Protective Role Of Panax ginseng On Hepatotoxicity Induced By Carbon Tetrachloride In Male Rats

Paper Details

Research Paper 08/05/2023
Views (665) Download (89)
current_issue_feature_image
publication_file

The Protective Role Of Panax ginseng On Hepatotoxicity Induced By Carbon Tetrachloride In Male Rats

Abdallah M. Sliai
Int. J. Biosci.22( 5), 96-102, May 2023.
Certificate: IJB 2023 [Generate Certificate]
Key: Carbon tetrachlorideHistomorphometryHistopathologyLiverPanax ginseng

Abstract

The present study aimed to investigate the possible protective effects of Panax ginseng C. A. MEYER (Araliaceae) on liver damage caused by carbon tetrachloride in rats. The histopathological changes and certain liver enzymes were investigated. The results showed that carbon tetrachloride causes elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels production of the liver and decreased nuclear area and nuclear volume in the liver of CCl4-treated rats. Histopathological observations indicated severe damage in the liver. Panax ginseng co-treatment to the CCl4-administered rats attenuated the increase of the liver enzymes and restored the mean values of the nuclear area and nuclear volume and the morphological damage in the liver was reduced. It is therefore suggested that the Panax ginseng can provide a protective effect against acute hepatic injury caused by CCl4 in rats.

VIEWS 102
Cover PDF

Amin A, Hamza AA. 2005. Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation. Toxicology 208, 367–375. https://doi.org/10.1016/j.tox.2004.11.039.

Basu S. 2003 Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology 189, 113-127. https://doi.org/10.1016/S0300-483X(03)00157-4.

Bellisle F, Blundell JE, Dye L, Fantino M, Fern E, Fletcher RJ, Lambert J, Roberfroid M, Specter S, Westenhofer J, Westerterp- Plantenga MS. 1998 Functional food science and behaviour and psychological functions. British. Journal of Nutrition 80, 173–193.

Bishayee A, Sarkar A, Chatterjee M. 1995. The hepatoprotective activity of carrot (Daucas carota L.) against carbon tetrachloride intoxication in mouse liver. Journal of Ethnopharmacology 47, 69– 74.

Boll M, Weber LWD, Becker E, Stampfl A. 2001a Hepatocyte damage induced by carbon tetrachloride: inhibited lipoprotein secretion and changed lipoprotein composition. Naturforsch 56, 283–290.

Boll M, Weber LWD, Becker E, Stampfl A. 2001b Pathogenesis of carbon tetrachloride-induced hepatocyte injury bioactivation of CCl4 by cytochrome P450 and effects on lipid homeostasis. Naturforsch 56, 111–121.

Cheeseman KH, Albano F, Thomasi A, Slater T. 1985 Biochemical studies on the metabolic activation of halogenated alkanes. Environmental Health Perspectives 64, 85-89.

Fan J, Chen Q, Wei L, Zhou X, Wang R, Zhang H. 2018. Asiatic Acid Ameliorates Ccl4-Induced Liver Fibrosis in Rats: Involvement of Nrf2/Are, Nf- Kappab / Ikappabalpha, and Jak1/Stat3 Signaling Pathways. Drug 12, 3595–3605. https://doi.org/10.2147/DDDT.S179876.

Gum SI, Ahn SJ, Kim SH,  Kim JJ, Shin HM, Cho MK. 2007 The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo(alpha) pyrene-induced toxicity through metabolic regulation of CYPIAI and GSTs. Journal of  Ethnopharmacoogy 112, 568–576. https://doi.org/10.1016/j.jep.2007.05.014.

Higuchi H, Gores GJ. 2003 Mechanisms of liver injury: an overview. Current   Molecular Medicine 3, 483–490. https://doi.org/10.2174/1566524033479528.

Kampen JV, Robertson H, Hagg T, Drobitch R. 2003. Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson’s disease. Experimental Neurology 184, 512-529. https://doi.org/10.1016/j.expneurol.2003.08.002.

Kim HJ, Chun YJ, Park JD, Kim SI, Roh JK, Jeong TC. 1997.  Protection of rat liver microsomes against carbon tetrachloride-induced lipid peroxidation by red Ginseng saponin through cytochrome P450 inhibition. Planta Medical 63, 415-418.

Lee HU, Bae EA, Han MJ, Kim DH. 2005. Hepatoprotective effect of 20(S)-ginsenoside Rg3 and its metabolite 20(S)-ginsenoside Rh2 on hydroperoxide-induced liver injury. Biology Pharmacology. Bulletin 28, 1992–1994. https://doi.org/10.1248/bpb.28.1992.

Lin CF, Wong K.L, Wu RS, Huang TC. 2003. Protection by hot water extract of Panaxnoto ginseng on chronic ethanol-induced hepatotoxicity. Phytother Research 17, 1119–1122.

Mannaa FM, Abdel-Wahhab A, Ahmed HH, Park MH. 2006. Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide – induced neurotoxicity in rats. Journal of Applied Toxicology 26, 198-206.

Reitman S, Frankel S. 1957. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. American. Journal of Clinical Pathology 28, 56-63.

Simeonova PP, Gallucci RM, Hulderman T, Wilson R, Kommineni C. 2001. The role of tumor necrosis factoralpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride. Toxicology and Applied Pharmacology 177, 112-120.

Singh U, Devaraj S, Jialal I. 2005. Vitamin E, oxidative stress, and inflammation. Annual Review of Nutrition 25, 151–174.

Teschke R. 2018. Liver Injury by Carbon Tetrachloride Intoxication in 16 Patients Treated with Forced Ventilation to Accelerate Toxin Removal via the Lungs: A Clinical Report. Toxics 6(2). https://doi.org/10.3390/toxics6020025.

Wang PY, Kaneko T, Tsukada H, Nakano M, Nakajima T, Sato A. 1997. Time courses of hepatic injuries induced by chloroform and by carbon tetrachloride: comparison of biochemical and histopathological changes. Arch. Toxicology 71, 638- 645.

Wang SY, Jiao H. 2000. Correlation of antioxidant capacities to oxygen radical scavenging enzyme activities in blackberry.Journal of Agricultural and Food Chemistry 48, 5672–5676.

Weber L, Boll M, Stampfl A. 2003. Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model. Critical Reveiw Toxicology 33, 105-136.

Wei YY, Fan M, Yuan, YY, Ga, Zhang YN, Han JC, Hao ZH. 2022. Protective Effect of Aqueous Extract of Yinshanlian on Acute Liver Injury Induced by Carbon Tetrachloride in Mice. Acta Veterinria. Zootech 53, 2333–2342.

Wolf PL. 1999. Biochemical diagnosis of liver diseases. Indian Journal of Clinical Biochemistry 14, 59-90.

Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H. 1998. Cancer chemoprevention and therapeutic activities of red ginseng. Journal of Ethnopharmacology 60, 71–78.

Yang LL, Yu WC, Yen KY. 1993. Immunopotentiator in Chinese medicinal ginsengs. In: Proceedings of the Sixth International Ginseng Symposium, 49–51.

Zhu Z, Hu, R, Li J, Xing X, Chen J, Zhou Q,  Sun J. 2021. Alpinetin Exerts Anti-Inflammatory, Anti-Oxidative and Anti-Angiogenic Effects through Activating the Nrf2 Pathway in Carbon Tetrachloride-Induced Liver Fibrosis. Intennational  Immunopharmacology 96, 107660. https://doi.org/10.1016/j.intimp.2021.107660.

Submit Manuscript