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Comparative study of β-thalassemia major among the patients from urban and rural population in Hyderabad region

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Research Paper 01/03/2018
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Comparative study of β-thalassemia major among the patients from urban and rural population in Hyderabad region

Ikram-ul Haq, Dileep Kumar, Sajjad Hussain, Munazza Raza Mirza, Ather Hameed, Nazia Parveen Gill
Int. J. Biosci.12( 3), 224-234, March 2018.
Certificate: IJB 2018 [Generate Certificate]
Key: antioxidantsBlood-hematologyHemoglobinIron accumulationTIBCβ-Thalassemia major

Abstract

The thalassemia is a common etiological, microcytic and hypochromic anemia. It is an autosomal genetic disorder caused by mutations in α and β globin genes. In this experiment, hematological study conducted among the β-thalassemia major patients selected from urban (n=20) and rural (n=20) areas of Hyderabad. Patients from both regions were arranged into two age-groups (group I=2-7 years and group II= 5-11 years). Each group comprised on 10 males and 10 females (half rural and half city) in total 20 of confirmed β-thalassemia major patients. With hematological analysis showed significant variation, like as lowest red blood cells (RBCs) measured in male patients of both groups from urban and rural patients than all females. The hemoglobin (HB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCH), mean corpuscular hemoglobin concentration (MCHC) and platelets (PLT) showed variable (p≥0.05) abnormal values in all patients over normal reference values. The Hb also observed as reduced in all patients especially in 5-11 years aged male patients (p≥0.05). Meanwhile total iron contents and iron binding capacity (TIBC) noted reversed to Hb contents in all β-thalassemia major. In conclusion, rises in hematological parameters and iron overload causes to enhance antioxidant activity (AOA). The AOA may be beneficial for lowering the stringency of developed oxidative stress due to iron overload. It could be dependent on the type of AOA as well as their sources. Growth failure is common in thalassemia patients, while it is achievable with blood transfusion and optimal balanced nutritional status.

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