home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Outcome of patients with crimean-congo hemorrhagic fever in Peshawar, Pakistan

Paper Details

Research Paper 01/11/2018
Views (275) Download (10)
current_issue_feature_image
publication_file

Outcome of patients with crimean-congo hemorrhagic fever in Peshawar, Pakistan

Ziauddin, Inayat Ullah, Hashmat Khan, Muhammad Kashif, Adil Khan, Asma Adil, Wasim Sajjad, Ihsan Ullah, Sahib Zada
Int. J. Biosci.13( 5), 128-133, November 2018.
Certificate: IJB 2018 [Generate Certificate]
Key: Crimean Congo Hemorrhagic FeverELISARibavirinRT-PCR

Abstract

Crimean-Congo Hemorrhagic Fever (CCHF) is an arthropod born zoonotic viral infection that is transmitted to humans by tick bite and contact with secretions, blood and tissues infected with the virus. CCHF is a fatal disease with mortality rate of 10-40%. This study was aimed to demonstrate the effect of Ribavirin on the outcome of patients with CCHF in a tertiary care hospital, Peshawar, Pakistan. Thirty confirmed cases of CCHF were enrolled in this cross-sectional study over a period of one year. Patients were divided into two groups based on their time of arrival to hospital. Group 1: Those who presented within 07 days of onset of disease (presented early). Group 2: Those who presented after 07 days of onset disease (presented late).Oral Ribavirin was given to all patients according to dose recommended by word health organization (WHO). Outcome in these two groups was compared. Out of 30 patients, 20 patients presented early and received concomitant Ribavirin. Among them, 18 patients recovered and 02 expired. Ten patients presented late and received concomitant Ribavirin. Among them, 02 patients recovered and 08 expired. CCHF is a deadly disease. The disease rapidly progresses to death if not treated timely. Early Ribavirin therapy significantly improves the recovery outcomes of CCHF.

VIEWS 6
Cover PDF

Alam MM, Khurshid A, Sharif S, Shaukat S, Rana MS, Angez M, Zaidi SS. 2013. Genetic analysis and epidemiology of crimean congo hemorrhagic fever viruses in Baluchistan province of Pakistan. BMC Infectious Diseases 13(1), 201.

Altaf A, Luby S, Ahmed AJ, Zaidi N, Khan AJ, Mirza S, McCormick J, Fisher-Hoch S. 1998. Outbreak of Crimean-Congo hemorrhagic fever in Quetta, Pakistan: contact tracing and risk assessment. Tropical Medicine and International Health 3(11), 878-882.

Athar MN, Baqai HZ, Ahmad M, Khalid MA, Bashir N, Ahmad AM,Bashir K. 2003. Short report: Crimean-Congo haemorrhagic fever outbreak in Rawalpindi, Pakistan, February 2002. The American Journal of Tropical Medicine and Hygiene 69, 284–287.

Begum F, Wisseman JR, Casals L. 1970. Tick-borne viruses of West Pakistan. IV.   Viruses similar to or identical with Crimean hemorrhagic fever (Congo- Semunya), Wad Medani and Pak Argas 461 isolated from ticks of the Changa. Manga Forest, Lahore District, and of Hunza, Gilgit Agency, West Pakistan. American Journal of Epidemiology 92, 197-202.

Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. 2013. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Research 100(1), 159-189.

Bosan AH, Asghar H, Dill AS, Kakar F, Toor Z, Altaf A. 2002. Crimean Congo hemorrhagic fever (CCHF) outbreak in Karachi. Pakistan Journal of Medical Research 41(1), 36–38.

Casals J. 1969. Antigenic similarity between the virus causing crimean hemorrhagic fever and congo virus. Proceedings of the Society for Experimental Biology and Medicine131, 233-236.

Casals J. 1978. Crimean-Congo hemorrhagic fever. In: Proceedings of an International Colloquium on Ebola Virus Infection and Other Haemorrhagic Fevers held in Antwerp, Belgium, 6-8 December 1977. Elsevier/North Holland Biomedical Press, Amsterdam.

Chumako M. 1979. A new virus disease. Crimean hemorrhagic fever (in Russia). Novel Medicine 4, 9-11.

Durrani AB, Shaikh M, Khan Z. 2007. Congo Crimean hemorrhagic fever in Baluchistan. Journal of the College of Physicians and Surgeons-Pakistan 17, 543-545.

Engin A, Arslan S, Kizildag S, Oztürk H, Elaldi N, Dökmetas I, Bakir M. 2010. Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever. Microbes and Infection 12(12-13), 1071-1078.

Ergonul O, Celikbas A, Baykam N, Eren S, Dokuzoguz B. 2006. Analysis of risk-factors among patients with Crimean-Congo Haemorrhagic fever virus infection: severity criteria revisited. Clinical Microbiology and Infection 12(6), 551-554.

Fajs L, Humolli I, Saksida A, Knap N, Jelovsek M, Korva M, Dedushai I, Avsic-Zupanc T. 2014. Prevalence of crimean-congo hemorrhagic fever virus in healthy population, livestock and ticks in Kosovo. PLoS One. 9(11), e110982.

Fisher-Hoch SP, Khan JA, Rehman S, Mirza S, Khurshid M, McCormick JB. 1995. Crimean-Congo hemorrhagic fever treated with oral ribavirin. Lancet 346, 472-475

Gear JH. 1979. Hemorrhagic fevers, with special reference to recent outbreaks in southern Africa. Reviewof Infectious Disease 1, 571-591.

Hoogstraal H. 1979. The epidemiology of tick–borne Crimean–congo hemorrhagic fever in Asia, Europe and Africa. Journal of Medical Entomology 15, 307-417.

Izadi S, Salehi M. 2009. Evaluation of the efficacy of Ribavirin therapy on survival of Crimean – Congo hemorrhagic fever patients: a case –control study. Japanese Journal of Infectious Diseases. 62(1), 11-15.

Jamil B, Hasan RS, Sarwari AR, Burton J, Hewson R, Clegg C. 2005. Crimean-Congo hemorrhagic fever: experience at a tertiary care hospital in Karachi, Pakistan. Transactions of the Royal Society of Tropical Medicine and Hygiene 99, 577–584.

lavi-Naini R, Moghtaderi A, Koohpayeh HR, Sharifi- Mood B, Naderi M, Metanat M. 2006. Crimean-Congo hemorrhagic fever in southeast of Iran. Journal of Infection 52, 378-382.

Metanat M, Sharifi-Mood B, Salehi M, Alavi-Naini R. 2006. Clinical outcomes in CCHF: a five- year experience in the treatment of patients with oral ribavirin. International Journal of Virology 2, 21-24.

Muhammad A, Anum S, Raazeyah I, Muhammad RS, Shane S. 2017. The reasons why Pakistan might be at high risk of Crimean Congo haemorrhagic fever epidemic; a Scoping review of the literature. Virology Journal 14(63), 11-14.

Sheikh SS, Sheikh AA, Sheikh NS, Tariq M. 2004. Ribavirin: an effective treatment of Crimean Congo Hemorrhagic fever. Pakistan Journal of Medical Sciences 20(3), 201–206.

Simpson DI, Knight EM, Courtois G, Williams MC, Weinbren MP, Kibukamusoke JW. 1979. Congo virus: A hitherto undescribed virus occurring in Africa. I. Human isolations-clinical notes. East African Medical Journal44, 86-92.

Soares-Weiser K, Thomas S, Thomson G, Garner P. 2010. Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis. BMC Infectious Diseases 10(1), 207.

Swanepoel R, Shepard AJ, Leman PA, Shepard SP, McGillivray GM, Erasmus MJ, Searle LA, Gill DE. 1987. Epidemiological and clinical features of Crimean-Congo hemorrhagic fever in Southern Africa. The American Journal of Tropical Medicine and Hygiene 36, 120-132.

Waqar S, Tariq WZ. 2006. Crimean Congo Hemorrhagic fever (CCHF) in Pakistan. Pakistan Journal of Pathology 17(2), 74–84.

Warts DM, Vssery MS, Nash O, Peters CJ, 1989. Inhibition of Crimean-Congo hemorrhagic fever, viral infectivity yields in vitro by ribavirin. The American Journal of Tropical Medicine and Hygiene41, 581–585.

Willams M, Tukei PM, Lule M, Mujomba E, Mukuye A. 1996. Virology; Identification studies.  East African Virus Research Institute 16, 24-26.

Submit Manuscript