Hepatic detoxification activity of Olea europaea L. leaves against paracetamol-induced liver toxicity in rats
Paper Details
Hepatic detoxification activity of Olea europaea L. leaves against paracetamol-induced liver toxicity in rats
Abstract
Hepatotoxicity is a critical impairment of liver caused by different reasons such as overdoses of some drugs like acetaminophen (paracetamol). The Olea europaea L. leaves have multiple pharmacological effects and may use as hepatic detoxification. 100 g of leaves powder has been macerated with 1000 ml absolute ethanol for 48 h., induction of hepatotoxicity in rats was done using 400 mg\kg of paracetamol, 25 mg/kg of silymarin was used as standard drug. Different concentrations ranged between 250, 500, 1000 and 2000 mg\kg of ethanolic extract were used to detoxing from rats liver. Liver enzymes (ALT, AST and ALP) have been measured after 24 h. of treatment. The results showed that the high level of (ALT, AST and ALP) has been reoptimized after treatment with different concentration. However, the concentration (2000 mg\kg) exhibited to regulate the liver enzyme better than other concentrations. We found that ethanol extract of Olea europaea L. leaves could act as hepatic detoxification agent in rats.
Acar-Tek N, Ağagündüz D. 2020. Olive Leaf (Olea europaea L. folium): Potential Effects on Glycemia and Lipidemia. Annals of Nutrition and Metabolism, 1-6.
Ansari R, Tripathi S, Patnaik G, Dhawan B. 1991. Antihepatotoxic properties of picroliv: an active fraction from rhizomes of Picrorhiza kurrooa. Journal of ethnopharmacology 34(1), 61-68.
Aycan İÖ, Tüfek A, Tokgöz O, Evliyaoğlu O, Fırat U, Kavak GÖ, Turgut H, Yüksel MU. 2014. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. International Journal of Surgery 12(3), 213-218.
Bianco A, Ramunno A. 2006. The chemistry of Olea europaea. Studies in natural products chemistry: Elsevier, p 859-903.
Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B. 1994. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology 19(5), 1141-1148.
Dekanski D, Janićijević-Hudomal S, Tadić V, Marković G, Arsić I, Mitrović DM. 2009. Phytochemical analysis and gastroprotective activity of an olive leaf extract. Journal of the Serbian Chemical Society 74(4), 367-377.
Dub AM, Dugani AM. 2013. Antithrombotic effect of repeated doses of the ethanolic extract of local olive (Olea europaea L.) leaves in rabbits. Libyan Journal of Medicine 8(1), 20947.
Esmaeili-Mahani S, Rezaeezadeh-Roukerd M, Esmaeilpour K, Abbasnejad M, Rasoulian B, Sheibani V, Kaeidi A, Hajializadeh Z. 2010. Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats. Journal of ethnopharmacology 132(1), 200-205.
Guinda Á, Castellano JM, Santos-Lozano JM, Delgado-Hervás T, Gutiérrez-Adánez P, Rada M. 2015. Determination of major bioactive compounds from olive leaf. LWT-Food Science and Technology 64(1), 431-438.
Lockyer S, Yaqoob P, Spencer J, Rowland I. 2012. Olive leaf phenolics and cardiovascular risk reduction: physiological effects and mechanisms of action. Nutrition and Aging 1(2), 125-140.
Mao SA, Glorioso JM, Nyberg SL. 2014. Liver regeneration. Translational Research 163(4), 352-362.
Michaut A, Moreau C, Robin MA, Fromenty B. 2014. Acetaminophen‐induced liver injury in obesity and nonalcoholic fatty liver disease. Liver International 34(7), e171-e179.
Ramellini G, and Meldolesi J. 1976. Liver protection by silymarin: in vitro effect on dissociated rat hepatocytes. Arzneimittel-Forschung 26(1), 69-73.
Servili M, Esposto S, Fabiani R, Urbani S, Taticchi A, Mariucci F, Selvaggini R, Montedoro G. 2009. Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure. Inflammopharmacology 17(2), 76-84.
Silva S, Gomes L, Leitao F, Coelho A, Boas LV. 2006. Phenolic compounds and antioxidant activity of Olea europaea L. fruits and leaves. Food Science and Technology International 12(5), 385-395.
Tacke F, Luedde T, Trautwein C. 2009. Inflammatory pathways in liver homeostasis and liver injury. Clinical reviews in allergy & immunology 36(1), 4-12.
Thabrew MI, Joice P, Rajatissa W. 1987. A comparative study of the efficacy of Pavetta indica and Osbeckia octandra in the treatment of liver dysfunction. Planta medica 53(03), 239-241.
Venkatachalam U, Muthukrishnan S. 2013. Hepatoprotective activity of Desmodium gangeticum in paracetamol induced liver damage in rats. Biomedicine & Preventive Nutrition 3(3), 273-277.
Vivek K, Pillai K, Hussian S, Balani D. 1994. Hepatoprotective activity of “jigrine” on liver damage caused by alcohol, Carbontetrachloride and paracetamol in rats. Indian Journal of Pharmacology 26(1), 35.
Reem Abdul-Al Raheem Alsaad, 2021. Hepatic detoxification activity of Olea europaea L. leaves against paracetamol-induced liver toxicity in rats. Int. J. Biosci., 18(1), 178-184.
Copyright © 2021 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.