Antibacterial and teratogenic activity of Eleusine indica leaf extracts

Paper Details

Research Paper 01/10/2018
Views (1512)
current_issue_feature_image
publication_file

Antibacterial and teratogenic activity of Eleusine indica leaf extracts

Joanna May G. Lindain, Rich Milton R. Dulay, Mary Jhane G. Valentino
J. Biodiv. & Environ. Sci. 13(4), 131-140, October 2018.
Copyright Statement: Copyright 2018; The Author(s).
License: CC BY-NC 4.0

Abstract

The present study determined the antibacterial activity of E. indica against E. coli and S. aureus at 12, 24 and 36 hrs of incubation. Also, its teratogenic potential using zebrafish as a model animal was made. Malformations which include stunted-tail, growth retardation, yolk deformity, and delayed development were observed. Similarly, mortality rate, hatchability and heartbeat of zebrafish embryo were also noted. Results showed bacterial inhibition against E. coli at 12, 24 and 36 hrs of incubation. For the teratogenicity of E. indica, LC50 of ethanol and hot water extracts was computed at 2200 ppm and 12890 ppm, respectively. Also, exposure of zebra fish embryo to ethanol extract of 10000 to 5000 ppm caused 100%mortality at 24 hours of incubation and reduced heartrates for the surviving embryos. Furthermore, malformations were also recorded which include stunted-tail, growth retardation, yolk deformity and delayed development. Thus, the potential antibacterial activity against E. coli and teratogenic potential of E. indica ethanol extracts.

Agati G, Azzarello E, Pollastri S, Tattini M. 2012. Flavonoids as antioxidants in plants: location and functional significance. Plant Science 196, 67-76. https://doi.org/10.1016/j.plantsci.2012.07.014.

Al-Zubairi AS, Abdul AB, Abdelwahab SI, Peng CY, Mohan S, Elhassan MM. 2009.  Eleucine indica possesses antioxidant, antibacterial and cytotoxic properties. Evidence- Based Complementary and Alternative Medicine. https://doi.org/10.1093/ecam/nep091

Anderson D. 2003. Persistence of antibiotic resistant bacteria. Current Microbiology 6, 452-456. http://dx.doi.org/10.1016/j.mib.2003.09.001

Arsad SS, Esa NM, Hamzah H. 2014.  Histopathologic changes in liver and kidney tissues from male Sprague Dawley rats treated with Rhaphidophora decursiva (Roxb.) Schott extract. Journal of Cytology and Histology S4, 001. https://doi.org/10.4172/2157-7099.

Awanchiri SS, Van Dufat HT, Chishirri J, Dongfack MDJ, Nguenang GM, Boutefnouchet S, Fomum ZT, Seguin E, Verite P, Tillequin F, Wandji J. 2009. Triterpenoids with antimicrobial activity from Drypetes inaequalis. Phytochemistry 70 (3), 419-423. https://doi.org/10.1016/j.phytochem.2008.12.017

Jahfar M. 2003. Glycosyl Composition of Polysaccharide from Tinospora Cordifolia Acta Pharmaceutica 53, 65.

Baradaran A, Nasri H, Nematbakhsh M, Rafieian-Kopaei M. 2014. Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats. Clinical Therapeutics 165 (1), 7–11 https://doi.org/10.7471/CT.2014.1653.

Cowan MM. 1999. Plant products as antimicrobial agents. Clinical Microbiology Review 12(4), 564-582.

Dulay RMR, Kalaw SP, Reyes RG, Alfonso N, Eguchi F. 2012.Teratogenic and Toxic effects of Lingzhi or Reishi medicinal mushroom,Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Higher Basidiomytes), on zebrafish embryo as model. International Journal of Medicinal Mushrooms 14, 507-512.

Iberahim R, Yaacob WA, Ibrahim N. 2015. Phytochemistry, cytotoxicity and antiviral activity of  Eleusine indica (sambau). AIP Conference Proceedings 1678, 030013. https://doi.org/10.1063/1.4931234

Koduru S, Grierson DS, Afolayan AJ. 2006. Antimicrobial activity of olanum aculeastrum. Pharmaceutical Biology 44(4), 283–286.

Krishnaraju AV, Rao TVN, Sundararaju D. 2005.. Assessment of bioactivity of Indian medicinal plants using Brine shrimp (Artemia salina) lethality assay. International Journal of Applied Science and Engineering 2, 125-134.

Lather A, Valecha R, Sharma K, Garg M. 2011. Worldwide potential of plants causing teratogenicity. Review Article Spatula 1(2), 102.

Nair R, Chanda S. 2004. Antibacterial activity of some medicinal plants of Saurashtra Region. Journal Tissue Residence 4, 117-120.

Rabe T, Van Staden J. 1997. Antibacterial activity of South African plants used for medicinal purposes. Journal of Ethno pharmacology 56(1), 81–87.

Srivastava J, Lambert J, Vietmeyer N. 1996. Medicinal plants: An expandingrole in development. World Bank Technical Paper.

Talhi O, Silva AMS. 2012. Advances in Cglycosyl flavonoid Research. Current Organic Chemistry 16(7),  859-896.

WHO. 2002. Traditional Medicine: Growing needs and potential who policy perspectives on medicines, World Health Organization, Geneva.

Xie Y, Yang W, Tang F, Chen X, Ren L. 2015. Antibacterial activities of flavonoids: structure-activity relationship and mechanism. Current Medical Chemistry 22(1), 132-49.

Related Articles

Agroforestry in woody-encroached Sub-Saharan savannas: Transforming ecological challenges into sustainable opportunities

Yao Anicet Gervais Kouamé, Pabo Quévin Oula, Kouamé Fulgence Koffi, Ollo Sib, Adama Bakayoko, Karidia Traoré, J. Biodiv. & Environ. Sci. 27(3), 10-22, September 2025.

Extreme rainfall variability and trends in the district of Ouedeme, municipality of Glazoue (Benin)

Koumassi Dègla Hervé, J. Biodiv. & Environ. Sci. 27(3), 1-9, September 2025.

Heterosis breeding, general and specific combining ability and stability studies in pearl millet: Current trends

Ram Avtar, Krishan Pal, Kavita Rani, Rohit Kumar Tiwari, Mahendra Kumar Yadav, J. Biodiv. & Environ. Sci. 27(2), 117-124, August 2025.

Combining ability, heterosis and stability for yield and fibre quality traits in cotton: Breeding approaches and future prospects

Rohit Kumar Tiwari, Krishan Pal, R. P. Saharan, Ram Avtar, Mahendra Kumar Yadav, J. Biodiv. & Environ. Sci. 27(2), 109-116, August 2025.

Bridging the COPD awareness gap in marginalized populations: Findings from a multicentre study in Khalilabad, Sant Kabir Nagar, Uttar Pradesh, India

Anupam Pati Tripathi, Jigyasa Pandey, Sakshi Singh, Smita Pathak, Dinesh Chaudhary, Alfiya Mashii, Farheen Fatima, J. Biodiv. & Environ. Sci. 27(2), 97-108, August 2025.

Antioxidant and anti-inflammatory activity of Pleurotus citrinopileatus Singer and Pleurotus sajor-caju (Fr.) Singer

P. Maheswari, P. Madhanraj, V. Ambikapathy, P. Prakash, A. Panneerselvam, J. Biodiv. & Environ. Sci. 27(2), 90-96, August 2025.

Mangrove abundance, diversity, and productivity in effluent-rich estuarine portion of Butuanon River, Mandaue City, Cebu

John Michael B. Genterolizo, Miguelito A. Ruelan, Laarlyn N. Abalos, Kathleen Kay M. Buendia, J. Biodiv. & Environ. Sci. 27(2), 77-89, August 2025.

Cytogenetic and pathological investigations in maize × teosinte hybrids: Chromosome behaviour, spore identification, and inheritance of maydis leaf blight resistance

Krishan Pal, Ravi Kishan Soni, Devraj, Rohit Kumar Tiwari, Ram Avtar, J. Biodiv. & Environ. Sci. 27(2), 70-76, August 2025.