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Frequency of hyponatremia and its common complications among patients with hepatic encephalopathy

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Research Paper 01/01/2017
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Frequency of hyponatremia and its common complications among patients with hepatic encephalopathy

Hashmat Ullah Khan, Fazal Malik, Yaseen Khan, Sahib Zada, Nikhat Ilahi, Mohammad Sohail, Wasim Sajjad
Int. J. Biosci.10( 1), 195-201, January 2017.
Certificate: IJB 2017 [Generate Certificate]
Key: CirrhosisHepatic encephalopathyHyponatremiaSpontaneous bacterial peritonitis

Abstract

The main theme of this study was to determine the frequency of hyponatremia and its common complications among patients suffering of hepatic encephalopathy due to liver cirrhosis. Descriptive cross sectional study was designed for current research. The samples were obtained from department of medicine, Lady Reading Hospital Peshawar, Pakistan. Total of 139 patients with hepatic encephalopathy and hyponatremia were analysed in this cross sectional study. Hepatic encephalopathy was ranked on the basis of West Haven classification (4 grades). Relationship of hyponatremia was correlated with severity grade of encephalopathy using Spearman rank correlation test. Male to female samples ratio was 1.48:1. The patient’s average age was 49.23 ± 10.24 years. Hyponatremia was found in 30 patients (21.60%). The most common complication was Worsening of Hepatic Encephalopathy which was observed in 15 patients (10.80%). Spontaneous Bacterial Peritonitis was also found in 9.4% patients. Higher probability of a possibly negative effect of lower serum sodium concentration and even a slight decline in the cirrhosis clinical course has been concluded.

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Ahmed H, Masood-Ur-Rehman, Saeedi I, Shah D. 2001. Factors precipitating Hepatic Encephalopathy in Cirrhosis Liver. Journal of Postgraduate Medical Institute 15, 91.

Angeli P, Wong F, Watson H. 2006. Genes PCAPPS Investigators. Hyponatremia in cirrhosis: Results of a patient population survey. Journal of Hepatology 44, 1535–1542.

Borroni G, Maggi A, Sangiovanni A, Cazzaniga M, Salerno F. 2005. Clinical relevance of hyponatraemia for the hospital outcome of cirrhotic patients. Digestive and Liver Disease 32(7), 605-610. http://dx.doi.org/10.1016/S1590-8658(00)80844-0

Cordoba J, Blei AT. 2007. Hepatic encephalopathy. In: Schiff ER, Sorrell MF, Maddrey WC, editors. Schiff’s diseases of the liver. 10th ed. Vol. 1. Philadelphia: Lippincott Williams & Wilkins. 569-99.

Cordoba J, Gottstein J, Blei AT. 1998. Chronic hyponatraemia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. Journal of Hepatology 29, 589-594.

Crawford JM. 2005. Liver and biliary tract. In: Kumar V, Abbas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease. 7th Ed. Philadelphia, Pa: Elsevier Saunders 877–938.

Ginès P, Cárdenas A, Schrier RW. 2006. Liver disease and the kidney. In: Schrier RW, editor. Diseases of the Kidney & Urinary Tract. Vol. 3. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins 2179–2205.

Haussinger D, Laubenberger J, vom Dahl S, Ernst T, Bayer S, Langer M, Wolfgang G, Jürgen H. 1994. Proton magnetic resonance spectroscopy studies on human brain myoinositol in hypo-osmolarity and hepatic encephalopathy. Journal of Gastroenterology 107, 1475-1480.

Haussinger D. 2006. Low grade cerebral edema and the pathogenesis of hepatic encephalopathy in cirrhosis. Journal of Hepatology 43, 1187-1190. http://dx.doi.org/10.1002/hep.21235.

Heidelbaugh JJ, Sherbondy M. 2006. Cirrhosis and chronic liver failure: Part II. Complications and treatment. American Family Physician 74, 767-776.

Heuman DM. 2010. Hyponatermia in cirrohsis answers and questions. Journal of Clinical Gastroenterology 44(3), 157-158. http://dx.doi.org/10.1097/MCG.0b013e3181c21b27

Malik A, Butt SA, Tariq WZ. 1996. Hepatitis C virus in perspective, where do we stand [editorial]. Journal of the College of Physicians and Surgeons Pakistan 6, 136.

Marshall AW, Kingstone D, Boss M. 1983. Ethanol elimination in males and females: relationship to menstrual cycle and body composition. Journal of Hepatology 3, 701.

Menon KV. 2001. Pathogenesis, diagnosis and treatment of alcoholoic liver disease. Mayo. Clinic. Proceedings 76, 1021.

Poordad FF. 2007. Review article: the burden of hepatic encephalopathy. Alimentary Pharmacology and Therapeutics 25(s1), 3-9. http://dx.doi.org/10.1111/j.1746-6342.2006.03215.x

Quittnat F, Gross P. 2006. Vaptans and the treatment of water-retaining disorders. Semin. Journal of Nephrology 26, 234–243. http://dx.doi.org/10.1016/j.semnephrol.2006.02.003

Restuccia T, Gomez-Anson B, Guevara M, Alessandria C, Torre A, Alayrach ME. 2004. Effects of dilutional hyponatraemia on brain organic osmolytes and water content in patients with cirrhosis. Journal of Hepatology 39, 1613-1622.

Ruiz del AL, Urman J, Fernandez J, Gonzalez M, Navasa M, Monescillo A. 2003. Systemic, renal and hepatic haemodynamic derangement in cirrhotic patients with spontaneous bacterial peritonitis. Journal of Hepatology 38, 1210-1218. http://dx.doi.org/10.1053/jhep.2003.50447

Saad M, Saleem A, Iqbal A. 2006. Precipitating factors of hepatic encephalopathy experience at Pakistan In situte of Medical sciences Islamabad; Journal of Ayub Medical College 18(4), 57-61.

Shahid A, Qureshi H, Nizami F, Zuberi SJ.1983. Electrolytes in liver diseases: A preliminary study. Journal Pakistan Medical Association 33, 289.

Shaikh S, Mal G, Khalid S, Baloch GH, Akbar Y. 2010. Frequency of hyponatraemia and its influence on liver cirrhosis-related complications. Journal Pakistan Medical Association 60(2), 116-120.

Sheikh A, Ahmad SI, Naseemullah M. 2001. Etiology of hepatic encephalopathy and importance of upper gastrointestinal bleeding and infections as precipitating factors. Journal of Rawalpindi Medical College 5, 10.

Shiekh S. 1998. Portal systemic encephalopathy in chronic liver disease. Experience at People Medical College, Nawabshah. Journal of the College of   Physicians and Surgeons Pakistan 8, 53.

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