Antidiarrhoeal activity of the leaf and fruit extracts of Dillenia indica
Paper Details
Antidiarrhoeal activity of the leaf and fruit extracts of Dillenia indica
Abstract
Plants are playing an important role in therapy of many diseases. Here we have studied on a plant which is Dillenia indica. In this study, ethanolic extract of the leaf and fruit of Dillenia indica was the experimental sample whereantidiarrhoeal activity was analyzed. The plant parts showed antidiarrhoeal activity which was measured by castor oil induced method and charcoal plug method. In case of castor oil induced method the percent of inhibition of wet feces was measured and significantly decreased the total number of feces produced by the administration of castor oil; in 2nd hour (for leaf extract, 6 for 200 mg/kg dose and 4 at dose of 400 mg/kg and for fruit extract, 5.33 for 200 mg/kg dose and 4 at dose of 400 mg/kg) and 3rd hour (for leaf extract,3 for 200 mg/kg dose and 2 at dose of 400 mg/kg and for fruit extract 4 for 200 mg/kg dose and 3 at dose of 400 mg/kg). In charcoal plug method the activity was measured by distance traveled by the charcoal plug. The result was slightly lower than the control and the standard loperamide showed the maximum antidiarrhoeal effect. The average distance traveled by leaf was 28.67 cm and fruit was 22.67 cm which was lower than the control 41 cm where as the standard loperamide showed the average traveled length of 16 cm.
Abdille MH, Singh RP, Jayaprakasha GK, Jena BS. 2005. Antioxidant activity of the extracts from dillenia indica fruits. Food Chem. 90, 891-896.
Awouters F, Niemegeers CJE, Lenaerts FM, Janseen PAJ. 1978. Delay of castor oil diarrhea in rats; a new way to evaluate inhibitors of prostaglandin biosynthesis. J Pharmacol. 30, 41-45.
Banerji N, Majumder P, Dutta NI. 1975. A new pentacyclic triterpene lactone from Dillenia indica. Phytochemistry 14, 289-292.
Bhakuni DS, Dhar ML, Dhar MN, Dhawan BN, Mehrotra BN. 1969. Screening of Indian plants for biological activity, II. Indian J Exp Biol. 7, 250.
Haque ME, Islam MN, Hossain M, Mohamad AU, Karim MF, Rahman MA. 2008. Antimicrobial and cytotoxic activities of Dillenia pentagyna. Dhaka Univ. J. Pharm. Sci. 7, 103-105.
Janick J, Paull RE. 2008. The encyclopedia of fruit and nuts. 1 st ed. London: CABI.
Koster R M, Anderson, De Beer EJ. 1959. Acetic acid for analgesic screening. Fed. Proc. 18, 412-418.
Kumar D, Mallick S, Vedasiromoni JR, Pal BC. 2009. Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC. Phytomedicine, 10.1016/j.phymed.2009.07.010.
Mukharjee PK, Saha K, Murugesan T, Mandal S C, Pal M, Saha B P. 1998. Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India. J Ethnopharmacol. 60, 85-89.
Olajide OA, Awe SO, Makinde JM. 1999. Pharmacological studies on the leaf of Psidium guajava. Fitoterapia 70, 25-31.
Parvin MN, Rahman MS, Islam MS, Rashid MA, 2009. Chemical and biological investigations of Dillenia indica Linn. Bangledesh J. Pharmacol. 4, 122-125.
Sharma HK, Chhangte L, Dolui AK. 2001. Traditional medicinal plants in Mizoram, India. Fitoterapia 72, 146-61.
Shoba FG, Thomas M. 2001. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol. 76(1), 73-6.
Shome U, Khanna KR, Sharma PH. 1980. Pharmacognostic studies on Dillenia indica Linn. II. Fruit and seed. Proc. Indian Acad. Sci. 89, 91-104.
Uddin SJ, Ferdous MM, Rouf R, Alam MS, Sarker MAM, Shilpi JA. 2005. Evaluation of anti- diarrhoeal activity of Enhydra fluctuans. J. Med. Sci. 5(4), 324-327.
Wong CL, Way MK. 1981. Effects of aspirin and paracetamol on naloxone reversal of morphine- induced inhibition of gastrointestinal propulsion in mice. Eur J Pharmacol 73, 11-19.
Yeshwante SB, A.R. Juvekar AR, Nagmoti DM, Wankhede SS, Shah AS, R.B. Pimprikar RB and Saindane DS. 2009. Anti-inflammatory activity of methanolic extracts of Dillenia indica L. leaves. Pharmacology 1, 63-66.
M Shafikur Rahman, KM Shams-Ud-Doha, Roksana Rahman, 2011. Antidiarrhoeal activity of the leaf and fruit extracts of Dillenia indica. Int. J. Biosci., 1(6), 39-46.
Copyright © 2011 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.