Interleukin-1 beta response to an acute incremental cycling in obese men

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Research Paper 01/10/2011
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Interleukin-1 beta response to an acute incremental cycling in obese men

Eizadi Mojtaba, Khorshidi Davood, Seyedhoseini MohammadAli, Dooaly Hussein
J. Bio. Env. Sci.1( 5), 82-88, October 2011.
Certificate: JBES 2011 [Generate Certificate]

Abstract

To compare of circulating levels of IL-1b as an inflammation cytokine between obese and none obese men and also to investigation its response to an acute exercise test. Fasting blood samples were obtained of adult obese (n=15) and none obese (n=14) men aged 40 ± 5 year in order to measuring serum IL-1b and glucose. In addition, blood samples were repeated immediately after a session cycling exercise in order to determine these variables responses to exercise test. Statistic analysis was done with SPSS 15.0 for Windows by using Student’s t-tests for independent and paired samples. At baseline, serum IL-1b level, glucose and insulin resistance in obese men were higher than those with normal weight (p < 0.05). Acute cycling test increased IL-1b (p = 0.037) and decreased glucose concentration (p = 0.024) without changes in insulin resistance (p = 0.126) on obese subjects. Obesity is associated with systemic inflammation. Despite the decrease in glucose concentration, but a session exercise does not lead to improved systemic inflammation in obese men.

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Adamopoulos   S,   Parissis    J,   Karatzas    D. 2002. Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure,” Journal of the American College of Cardiology 39(4), 653–663.

Anker SD, Von Haehling S. 2004. Inflammatory mediators in chronic heart failure: an overview. Heart 90, 464-70.

Bergeron R, RussellRR, Young LH. 1999. Effect of AMPK activation on muscle glucose metabolism in conscious rat. Am.J. Physiol. 276, 938-944.

Bonyadi M, Badalzadeh R, Mohammadi M, Poozesh S, Salehi I. 2009. The effect of regular training on plasma cytokines response in healthy and diabetic rats. Saudi Med J 30(11), 1390-4.

Cesari M, Kritchevsky SB, Baumgartner RN, Atkinson HH, Penninx BW, Lenchik L et al. 2005. Sarcopenia, obesity, and inflammation— results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr 82, 428–434.

Conraads VM, Beckers P, Bosmans J. 2002. Combined endurance/resistance training reduces plasma TNF-α receptor levels in patients with chronic heart failure and coronary artery disease,” European Heart Journal 23(23), 1854–1860.

Damirchi A, Rahmani-Nia F, Mehrabani J. 2011. Effect of single bout graded exercise on the cytokines and insulin resistance index. Brazilian Journal Of Biomotricity 5(2), 132-140.

Dandona P, Aljada A, Bandyopadhyay A. 2004. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol Trends Immunol 25(1), 4-7.

Dinarello CA. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27, 519-50.

Gielen S, Adams V, Oius-Winkler SM. 2003. Antiinflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure,” Journal of the American College of Cardiology 42(5), 861–868.

Gomez-Merino D, Drogou C, Guezennec CY, Chennaoui M. 2007. Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats. Cytokine 40(1), 23-9.

Juge-Aubry CE, Somm E, Chicheportiche R. 2004. Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. J Clin Endocrinol Metab 89, 2652–2658.

Kathrin M, Gitanjali D, Desiree M. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opin. Biol. Ther 9(9), 1177-1188.

Larsen  AI, Lindal  S, Aukrust  P, Toft  I, Aarsland T, Dickstein K. 2002. Effect of exercise training on skeletal muscle fibre characteristics in men with chronic heart failure. Correlation between skeletal muscle alterations, cytokines and exercise capacity,” International Journal of Cardiology 83(1), 25–32.

Manica-Cattani MF, Bittencourt L, Rocha MI, Algarve TD, Bodanese LC, Rech R. 2010. Association between interleukin-1 beta polymorphism (+3953) and obesity. Mol Cell Endocrinol 314(1), 84-9.

Markovic O, O’Reilly G, Fussell HM. 2004. Role of single nucleotide polymorphisms of proinflammatory cytokine genes in the relationship between serum lipids and inflammatory parameters, and the lipid-lowering effect of fish oil in healthy males. Clin Nutr 23, 1084–95.

Maruyama Y, Nordfors L, Stenvinkel P. 2005. Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease. Blood Purif 23, 384–93.

Matsuki T, Horai R, Sudo K, Iwakura Y. 2003. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med 198(6), 877-88.

Meier CA, Thalmann S. 2007. White adipose tissue, inflammation and atherosclerosis. Bull Acad Natl Med 191(4-5), 897-908.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Smart NA, Larsen AI, Le Maitre JP, Ferraz AS. 2011. Effect of Exercise Training on Interleukin-6, Tumour Necrosis Factor Alpha and Functional Capacity in Heart Failure. Cardiol Res Pract 11, 521-8.

Suzuki K. Nakaji S, Yamada M, Totzuka M, Sato K, Sugawara K. 2002. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exercise Immunology Review 7, 6-48.

Takizawa H. 1998. Cytokines/chemokines and adhesion molecules in local inflammatory responses of the lung. Drug News Perspect 11(10), 611-9.

Trayhurn  P,Wood  IS.  2004.  Adipokines: inflammation  and  the  pleiotropic  role  of  white adipose tissue. Br J Nutr 92, 347–355.

Um JY, Chung HS, Song MY, Shin HD, Kim HM. 2004. Association of interleukin-1beta gene polymorphism with body  mass index in women. Clin Chem 50, 647–650.