Computational analysis of milk sources from different domestic animals as supplementary food source to protect Lathyrism
Paper Details
Computational analysis of milk sources from different domestic animals as supplementary food source to protect Lathyrism
Abstract
Lathyrism, a neurological disease caused by excessive consumption of Lathyrus sativus due to presence of non protein amino acid beta-N-oxylamino-L-alanin acid (BOAA) or beta N-oxalyl diamino propionic acid (beta-ODAP) results in non progressive spastic paralysis in human and animals. The lathyrism thought to cause due to sulfur amino acids deficiency. To investigate the protective action of sulfur rich amino acids (Cysteine and Methionine) in four milk proteins viz. alpha S1 casein, alpha S2 casein, beta casein and kappa casein present in common milk sources of cow (Bos Taurus), buffalo (Bubalus bubalis), goat (Capra hircus) and sheep (Ovis aries). ProtParam, CLUSTALW and PSIpred were used to analyze primary structure, multiple sequencealignment and secondary structure respectively. Current study revealed that buffalo and sheep milk contain highest amount of Cysteine and Methionine (14.2%) as sulfur rich amino acids, cow milk has significant amount of Cysteine and Methionine (13.1%) while goat milk contain lowest amount of Cysteine and Methionine (13.0%). This study paves the way that buffalo and sheep milk are the best sources of sulfur amino acids than the other two and can be used as supplementary food to protect Lathyrism.
Bachhuber TE, Lalich JJ, Angevine DM, Schilling ED, StrongFM. 1955. Lathyrus factor activity of aminopropionitrile and related compounds. Proceedings of the Society for Experimental Biology and Medicine 89, 224
Chowdhury SD , Sultana Z, Ahammed M, Chowdhury BL, Das SC, Roy. 2005. The Nutritional Value of Khesari (Lathyrus sativus) for Growing and Laying Pullets.The Jorurnal of Poultry Science 42(4), 308-320.
Eguchi KK, Yoshino N, Minoura A, Watanabe K, Kusama T, Lambein F, Ikegam F. 2011. Sulfur amino acids deficiency caused by grass pea diet plays an important role in the toxicity of l-β-ODAP by increasing the oxidative stress:Studies on a motor neuron cell line. Food and Chemical Toxicology 49(3). 636–643.
Fikre A, Yami A, Kuo YH, Ahmed S, Gheysen G, Lambein F. 2010. Effect of methionine supplement on physical responses and neurological symptoms in broiler chicks fed grass pea (Lathyrus sativus)-based starter ratio.Food and Chemical Toxicology 48, 11–17.
Fox PF, McSweeney PLH. 1998. Milk proteins. In: Dairy chemis. and biochemistry. Blackie Academic & Professional, London, 146.
Getahun H, Lambein F. 2005. Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidants.Tropical Medicine and International Health 10, 169-178.
Haimanot RT, Kidane Y. 1990. Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. International Journal of Epidemiology. 19(3), 664-72.
Haque A, Hossain M. 1996. Epidemiological study of lathyrism in northwestern districts of Bangladesh.Neuroepidemiology 15(2), 83-91.
Lambein F and Ahmed S. 2005. The same goal, a different approach: a new Belgian-Ethiopian project. Lathyrus Lathyrism Newsletter.
Rao AV, Balachandran B. 2002. Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutritional Neuroscience 5, 291-309.
Shinomol, G. K. and Muralidhara. 2007. Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal.Neurotoxicology 18(4), 798-806.
Spencer PS, Ludolph AC, Kisby GE. 1993.Neurologic diseases associated with use of plant components with toxic potential. Environmental Research 62(1), 106–113.
Spencer PS, Schaumburg HH. 1983. Lathyrism: a neurotoxic disease. Neurobehavioral Toxicology and Teratology 5(6). 625-9.
Sriram K, Shankar SK, Boyd MR, Ravindranath V. 1998. Thiol Oxidation and Loss of Mitochondrial Complex I Precede Excitatory Amino Acid-Mediated Neurodegeneration.The Journal of Neuroscience 18 (24).. 10287–10296.
Hammadul Hoque, Shafi Jamali, Jebin Akther, Shamsul H. Prodhan, 2012. Computational analysis of milk sources from different domestic animals as supplementary food source to protect Lathyrism. Int. J. Biosci., 2(7), 74-82.
Copyright © 2012 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.