Studies of the effects of aqueous extract of Garcinia kola on fatigue and memory in Wistar Rats
Paper Details
Studies of the effects of aqueous extract of Garcinia kola on fatigue and memory in Wistar Rats
Abstract
The objective of this study is to evaluate the possible effects of the aqueous extract of Garcinia kola at the dose of 1000 mg/kg (EAGk) on the decrease of vigilance. This decrease in alertness is due to fatigue and memory impairment promoted by sleep deprivation for 7 consecutive days on wistar rats. 18 male rats aged 8 weeks weighing between 200 and 220g, divided into 3 groups of 6 rats, were subjected to sleep deprivation using a modified multiple platform. On the seventh day, the groups were subjected to different behavioral tests. It appears from our results that: In terms of fatigue, the analysis of the results of the openfield and the elevated cross labyrinth indicates that the rats treated with aqueous extract of Garcinia kola, present reduction of anxiety. The exhaustive nation test shows that the rats treated with aqueous extract of Garcinia kola have a good muscular performance. Regarding memory disorders, these rats treated with aqueous extract of Garcinia kola and deprived of sleep do not show any sign of memory impairment in the Y- labyrinth and objects recognition tests. In general, our results showed that the aqueous extract of Garcinia kola prevents the decrease in vigilance through its anxiolytic effects that eliminate anxiety and improves muscle performance but especially that allow increasing the learning capacity and the potential of memorization.
Adjanohoun E, et Aké Assi L. 1979. Contribution au recensement des plantes médicinales de Côte d’Ivoire. Centre National de Floristique, Abidjan: 359 p.
Ahn SH. 2013. Basal anxiety during an open field test is correlated with individual differences in contextually conditioned fear in mice. Animal Cells and Systems 17(3), 154.
Aké-Assi L. 1984. Flore de Côte d’Ivoire: étude descriptive et biogéographique, avec quelques notes ethnobotaniques. Thèse de Doctorat, Fac. Des Sciences, Université d’Abidjan, 6 fascicules, 1206 p.
Alaje DO, Owolabi KT, Olakunle TP, Oluoti OJ, Adetuberu IA. 2014. Nutritional, Minerals and Phytochemicals composition of Garcinia cola (Bitter cola) and Aframomum melegueta (Alligator pepper). Journal of Environmental Science, Toxicology And Food Technology 8(1), 86-91.
Almagro CB. 1976. Esquemas y practices de farmacologia. Editorial Espaxs, Barcelone (Espagne), 283 pp.
Al-saleh I, Billedo G, El-doush I. 2006. Levels of selenium, DL-α-tocopherol, DL-γ-tocopherol, all-trans-retinol, thymoquinoneand thymol in different brands of Nigella sativa seeds. Journal of Food Composition and Analysis 19, 167-75.
Alzoubi KH, Khabour OF, Tashtoush NH, AI-Azzam SI, Mhaidat NM. 2013. Evaluation of the Effect of Pentoxifylline on Sleep- Deprivation Induced Memory Impairment. Hippocampus 23(9), 812-819.
Antunes M, Biala G. 2012. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cognitive Processing 13(2), 93-110.
Banks S, Dinges DF. 2007. Behavioral and physiological consequences of sleep restriction. Journal of Clinical Sleep Medicine 3(5), 519-528.
Biyiti LF, Meko’o DJL, Tamzc V, Amvam Zollo PH. 2004. Recherche de l’activité antibactérienne de quatre plantes médicinales camerounaises. Pharmacopée et médecine traditionnelle africaine 13, 11-20.
Borbely AA. 2000. Introduction, chapter The Regulation of sleep. Human Frontier Science Program, Strasbourg (France), pp 17–25.
Borsini F, Meli A. 1988. Is the forcedswimming test a suitable model for revealing antidepressant activity? Psychopharmacology 94, 147-60.
Cheikh-Rouhou S, Besbes S, Hentati B. 2007. Nigella sativa L. Chemical composition and physicochemical characteristics of lipid fraction. Food Chemistry 101, 673-81
Cheikh-Rouhou S, Besbes S, Lognay G. 2008. Sterol composition of black cumin (Nigella sativa L.) and Aleppo pine (Pinus halpensis Mill.) seed oils. Journal of Food Composition and Analysis 21, 162-8.
Dalsgaard MK, Secher NH. 2007. The Brain at Work: A Cerebral Metabolic Manifestation of Central Fatigue. Journal of Neuroscience Research 85(15), 3334-3339.
Dellu F, Mayo W, Cherkaoui J, Le Moal M, Simon H. 1992. A twotrial memory task with automated recording: study in young and aged rats. Brain Research 588, 132-139.
Detke MJ, Rickels M, Lucki I. 1995. Active behaviors in the rat FST differentially produced by serotonergic and noradrenergic anti-depressants. Psychopharmacology 119, 47-54
Dibong SD, MpondoMpondo E, Ngoye A, Kwin NF. 2011c. Plantes médicinales utilisées par les populations bassa de la région de Douala au Cameroun. International Journal of Biological and Chemical Sciences 5, 1105-1117.
Dibong SD, MpondoMpondo E, Ngoye A, Kwin NF, Betti JL. 2011a. Ethnobotanique et phytomédecine des plantes médicinales vendues sur les marchés de Douala, Cameroun. Journal of Applied Biosciences 37, 2496-2407.
Dijk DJ, Beersma DG, Daan S, Bloem GM, Van den Hoofdakker RH. 1987. Quantitative analysis of the effects of slow wave sleeps deprivation during the first 3 h of sleep on subsequent eeg power density. European archives of psychiatry and neurological sciences 236(6), 323-328.
Drummond SP, Brown GG. 2001. The effects of total sleep deprivation on cerebral responses to cognitive performance. Neuropsychopharmacology, official publication of the American College of Neuropsychopharmacology 25, 68-73
Drummond SP, Brown GG, Gillin JC, Stricker JL, Wong EC, Buxton RB. 2000. Altered brain response to verbal learning following sleep deprivation. Nature 403, 655-657
Ennaceur A, Delacour J. 1988. A new one-trial test for neurobiological studies of memory in rats. Behavioural Brain Research 31, 47-59.
Finsterer J. 2012. Biomarkers of peripheral muscle fatigue during exercise. BMC Musculoskelet Disord 13, 218.
Gasmi S, Rouabhi R, Kebieche M, Boussekine S, Salmi A, Toualbia N, Taib CH, Bouteraa Z, Chenikher H, Henine S, Djabri B. 2017. Effects of Deltamethrin on striatum and hippocampus mitochondrial integrity and the protective role of Quercetin in rats. Environnemontale Science Pollution Reseach 24(19), 16440-16457
Graves LA, Heller EA, Pack AI, Abel T. 2003. Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning. Learning & memory 10, 168-176
Hall CS. 1934. Emotional behaviour in the Rat. I. Defecation and urination as mesures of individual differences in emotionality. Journal of Comparative Psychology 18, 385-403.
Harborne J. 1984. Un guide pour les techniques modernes de l’analyse des végétaux. Harborne J B, éditeur. London: Chapman and Hall; 192 p.
Harrison Y, Horne JA. 2000. The impact of sleep deprivation on decision making: a review. Journal of experimental psychology 6, 236-249
Hou JG, Xue JJ, Lee M, Yu JJ, Sung C. 2014. Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus. International Journal of Molecular Medicine 33, 234-240.
Kirk RS, Sawyer R. 1998. La composition et l’analyse des aliments de Pearson. Éditeur Longman Education Ltd au Royaume-Uni pp.707-708.
Koella WP. 1982. Amodern neurobiological concept of vigilance. Experientia 38(12), 1426-37
Lu C, Shi Z, Dong L. 2017. Exploring the effect of ginsenoside Rh1 in a sleep deprivation-induced mouse memory impairment model. Phytotherapy Research 31, 763-70.
Lueptow LM. 2017. Novel Object Recognition Test for the Investigation of Learning and Memory in Mice. Journal of Visualized Experiments 126, 55718
Maquet P. 2001. The role of sleep in learning and memory. Science 294 (5544), 1048-52.
Medeiros R, Lenneberg-Hoshino C, Hoshino K, Tufik S. 1998. Neuroethologic differences in sleep deprivation induced by the single-and multiple-platform methods. Brazilian Journal of Medical and Biological Research 31(5), 675-680.
Merfort I, Wray V, Barakat H. 1997. Flavonoltriglycosides from seeds of Nigella sativa. Phytochemistry 46, 359-63
Minzenberg MJ, Carter CS. 2008. Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33, 1477-1502
Mpondo Mpondo E, Dibong SD. 2012. Traditional knowledge on medicinal plants use by ethnic communities in Douala, Cameroon. European Journal of Medicinal Plants 2, 159-176.
N’Guessan K. 2008. Plantes médicinales et pratiques médicinales traditionnelles chez les peuples Abbey et Krobou du Département d’Agboville (Côte d’Ivoire). Thèse de Doctorat d’Etat ès Sciences Naturelles, Spécialité Ethnobotanique, Université de Cocody-Abidjan (Côte d’Ivoire), UFR Biosciences, Laboratoire de Botanique 335 p.
NicDhonnchadha BA, Bourin M, Hascoët M. 2003. Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety. Behavioural Brain Research 140, 203-214.
Ogu EO, Agu RC. 1995. A composition of some chemical properties of Garcinia Kola and HPS for the assessment of Garcinia Brewing value. Bioresearch Technology 54, 1-4.
Organisation Mondiale de la Santé (OMS). 2002. Stratégie de l’OMS pour la médecine traditionnelle pour 2002-2005, Genève. 78p.
Palchykova S, Winsky-Sommerer R, Meerlo P, Durr R, Tobler I. 2006. Sleep deprivation impairs object recognition in mice. Neurobiology of Learning and Memory 85, 263-271
Pellow S, Chopin P, File SE, Briley M. 1986. Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods 14, 149-167.
Perveen T, Haider S, Zuberi N. 2014. Increased 5-HT levels following repeated administration of Nigella sativa L. (black seed) oil produce antidepressant effects in rats. Scientia Pharmaceutica 82, 161-70
Piérard C, Liscia P, Philippin J. 2007. Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice. Pharmacology, Biochemistry and Behavior 88, 55-63.
Pires GN, Tufik S, Andersen ML. 2013. Grooming analysis algorithm: Use in the relationship between sleep deprivation and anxiety-like behavior. Progress in Neuro-Psychopharmacology and Biological Psychiatry 41, 6-10.
Rahman Mahbubur, Dong Kwon Yang, Gi‑beumBim, Sei‑jin Lee, Shang‑jin Kim. 2017. Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats. Biomedical Reports 6, 468-474.
Sanderson DJ, Sprengel R, Seeburg PH, Bannerman DM. 2011. Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory. Learning and Memory 18, 128-131.
Smith C, Rose GM. 1996. Evidence for a paradoxical sleep window for place learning in the Morris water maze. Physiology & behavior 59, 93-97
Smith C, Rose GM. 1997. Posttraining paradoxical sleep in rats is increased after spatial learning in the Morris water maze. Behavioral neuroscience 111, 1197-1204
Smith I, Williamson EM, Putnam SE, Farrimond J, Whalley BJ. 2014. Effects and mechanisms of ginseng and ginsenosides on cognition. Nutrition Reviews 72, 319-333.
Tra Bi FH. 1997. Utilisation des plantes, par l’homme, dans les forêts classées du Haut-Sassandra et de Scio, en Côte-d’Ivoire, Thèse de Doctorat de 3ème Cycle, Université de Cocody-Abidjan, F.A.S.T, N° d’ordre: 257/97, 212 p.
Valeria C, Paolo FF, Gigliola GZ, Fabien P, Giuseppe B. 2013. Experimental sleep deprivation as a tool to test memory deficits in rodents. Frontiers in Systems Neuroscience 7, 106-123.
Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T. 2009. Sleep deprivation impairs cAMP signalling in the hippocampus. Nature 461, 1122-1125
Vivien J, Faure JJ. 1996. Fruitiers sauvages d’Afrique (Espèces du Cameroun). Ministère Française de la Coopération et CTA. 416 p.
Walker MP, Stickgold R. 2006. Sleep, memory, and plasticity. Annual review of psychology 57, 139-166.
Wang YZ, Chen J, Chu SF. 2009. Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1’s metabolites ginsenoside Rh1 and protopanaxatriol. Journal of Pharmaceutical Sciences 109, 504-510.
Weiyue Zhang, Wei Zhang, NingDai, Chenxia Han, Fengzhi Wu, Xu Wang, LiboTan, Jie Li, Feng Li, Qingjia Ren. 2018. A Rat Model of Central Fatigue Using a Modified Multiple Platform Method. Journal of Visualized Experiments Neuroscience 138, 2- 10.
Yoo SS, Hu PT, Gujar N, Jolesz FA, Walker MP. 2007. A deficit in the ability to form new human memories without sleep. Nature neuroscience 10, 385-392
Augustin N’da Kouassi Kangah, Kakou Luc Gbalou, Seydou Silue, Rodrigue Bou, N’cho Arthur N’guessan, Léon Glin (2023), Studies of the effects of aqueous extract of Garcinia kola on fatigue and memory in Wistar Rats; IJB, V23, N2, August, P264-276
https://innspub.net/studies-of-the-effects-of-aqueous-extract-of-garcinia-kola-on-fatigue-and-memory-in-wistar-rats/
Copyright © 2023
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0