Evaluation of the anti-inflammatory activity of aqueous extracts from Parquetina nigrescens (Afzel.) Bullock (Apocynaceae)
Paper Details
Evaluation of the anti-inflammatory activity of aqueous extracts from Parquetina nigrescens (Afzel.) Bullock (Apocynaceae)
Abstract
The decoction of the leaves of Parquetina nigrescens (Apocynaceae) is used by Ivorian traditional healers for the treatment of inflammation. Regarding this traditional practice, the present study aimed at evaluating through outa scientific approach the anti-inflammatory activity of the aqueous extracts from Parquetinanigrescens leaves. The extracts were tested according to the model of acute rat paw oedema induced by 1% carrageenan. Several doses of phytomedicines were administered orally to the animal sand ranging as follows: 1600, 2400, 4800 mg/kg. The results obtained with the aqueous extracts of Parquetinanigrescens leaves were firstly compared with those of physiological control (NaCl 0.9%) and thereafter with those of the reference (diclofenac sodium 25 mg/kg). The comparisons were performed at 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 12 hours and 15 hours after injecting carrageenan into rats. The parameters considered for this purpose arethe percentage increase of paw circumference (%AUG) and the percentage inhibition of treatment (%INH). Thus, therewas a significant difference (p<0.001) between the %AUG of phytomedicine treatment at different doses and those of saline (NaCl). However, for a dose of 4800 mg/kg, when administered byoralroute, the AUG of the phytomedicine are statistically the same as those of diclofenac (25 mg/kg). Comparisons of %INH leadto similar results with %AUG. This study, therefore, confirms the anti-inflammatory properties of Parquetina nigrescens leaves and emphasizes the empirical use of that plant species in the treatment of inflammation.
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Ta Bi Irié Honoré, Dro Bernadin, Ake Claude Bernard, Ake-Assi Ablan Emma, N’guessan Koffi, University of Man, Côte d’Ivoire, UFR Agronomic Forestry, Environmental Engineering (IAFE) (2024), Evaluation of the anti-inflammatory activity of aqueous extracts from Parquetina nigrescens (Afzel.) Bullock (Apocynaceae); IJB, V24, N2, February, P51-57
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