Role of hSRBC, a putative TSG, in development of primary cancer: a review
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Abstract
Multistep progression into cancer involves inactivation of tumor suppressor genes (TSGs) by deletion, methylation and mutation. Chr 11p15 has been found to be deleted in primary carcinoma of many tissues, including breast, cervix, stomach, lung, bladder cancer, etc. hSRBC, a candidate TSG located in chr 15.4, and associated with many molecular pathways, like PKC-δ, p53 and caveolin pathway may well be responsible for tumirogenesis. hSRBC can induce cell cycle arrest and increase the apoptotic sensitivity of cells in stressed condition by stabilizing p53. hSRBC can also associate with caveolin when caveolae bud to form vesicles. hSRBC also effects localization of EGFR to caveolae through phosphorylation by PKC-δ. Thus, inactivation of hSRBC plays havoc inside the cell. Future hope may lie in restoring the function of hSRBC in cells and guiding the affected cells to apoptotic pathway instead of using radiation or chemotherapy.
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Dipanjana Mazumder, 2024. Role of hSRBC, a putative TSG, in development of primary cancer: a review. Int. J. Biosci., 24(6), 13-17.
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