Assessment of the antioxidant capacity and total polyphenol and flavonoid contents of extracts from three plants used in the treatment of menopausal symptoms in Côte D’ivoire
Paper Details
Assessment of the antioxidant capacity and total polyphenol and flavonoid contents of extracts from three plants used in the treatment of menopausal symptoms in Côte D’ivoire
Abstract
Polyphenols and flavonoids, two major classes of phytochemicals, are known for their antioxidant, anti-inflammatory and hormonal properties. Their presence in plants may help alleviate menopausal symptoms, such as hot flashes, irritability and sleep disturbances, by neutralizing free radicals and modulating inflammatory responses. The aim of this study was to assess the total polyphenol and flavonoid contents of three plants, and to investigate their antioxidant potential. The spectrophotometric determination of total polyphenols and flavonoids and the quantitative evaluation of the antioxidant activity towards the stable radical 1,1- diphenyl-2-picrylhydrazyl (DPPH) of three plants used in the treatment of menopausal symptoms in Côte d’Ivoire were carried out. Results showed that methanolic extracts of the leaves of Manihot esculenta, Talinum fruticosum and Khaya senegalensis contained varying levels of both polyphenols and total flavonoids. The methanolic extracts of the leaves of M. esculenta, K. senegalensis and T. fruticosum, revealed that the leaves of M. esculenta and K. senegalensis respectively contain the highest quantities of polyphenols (55896.55 μg EAG/g DM; 35810.35 μg EAG/g DM) and flavonoids (1943.66 ± 65.18 mg EQ/g DM; 1780.92 ± 173.27 mg EQ/g DM). For antioxidant activity, the IC50 values observed showed that M. esculenta (IC50 = 0.122 ± 0.0005 mg/ml) and K. senegalensis (IC50 = 0.227 ± 0.0015 mg/ml) extracts were the most active after ascorbic acid used as a control. Regular consumption of these plants could play an important role in controlling menopausal symptoms.
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