Increased IL-6 and is associated with decreased glucose concentration during cycling exercise
Paper Details
Increased IL-6 and is associated with decreased glucose concentration during cycling exercise
Abstract
Review of research findings show higher circulating interleukin 6 in diabetic patients than healthy people. The aim of our work was to study evaluate effects of exercise on serum interleukin 6 and insulin sensitivity in type II diabetic patients. Blood samples were derived from brachial vein before and immediately after YMCA cycling protocol of 16 healthy non-trained adult men with type II diabetic that participated in this study by voluntarily. Blood samples were used for measuring serum interleukin 6 and insulin sensitivity of all patients. We observed an increase in serum interleukin 6 by exercise test when compared to baseline. Glucose concentration was decreased in response to exercise test, while insulin sensitivity did not change. Based on these data, we can conclude that acute exercise test increase serum interleukin 6 and decrease glucose concentration in the absence of changes in insulin sensitivity in diabetic patients.
Bloem CJ, Chang AM. 2008. Short-Term Exercise Improves B- Cell Function and Insulin Resistance in Older People with Impaired Glucose Tolerance. J Clin Endocrinol Metab 93(2), 387-92.
Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G. 2006. Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase. Diabetes 55(10), 2688-97.
Duncan M, Singh B, Wise P. 1995. A simple measure of insulin resistance. Lancet 346, 120–1.
Eizadi M, Parsian H, Faraji GR, Zand A. 2011. Simultaneous increased Inteleukine-6 and decreased glucose concentration in response to a single bout cycling exercise. Journal of Biodiversity and Environmental Sciences 1(2), 45-51.
Fiers W. 1991. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS Lett 285, 199-212.
Fontana L, Eagon JC, Trujillo ME. 2007. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56, 1010-13.
Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444, 860-7.
Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. 2004. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun 320, 449–454.
King DE, Carek P, Mainous AG 3rd, Pearson WS. 2003. Inflammatory markers and exercise: differences related to exercise type. Med Sci Sports Exerc 35, 575-581.
Kopp HP, Kopp CW, Festa A. 2003. Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arterioscler Thromb Vasc Biol 23, 1042-7.
Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, and Hennekens CH. 1992. A prospective study of exercise and incidence of diabetes among United States male physicians. JAMA 268, 63–67.
Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, and Speizer FE. 1991. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338, 774–778.
Matthys P, Mitera T, Heremans H, Van Damme J, Billiau A. 1995. Anti-gamma interferon and antiinterleukin-6 antibodies affect staphylococcal enterotoxin B-induced weight loss, hypoglycemia, and cytokine release in D-galactosamine-sensitized and unsensitized mice. Infect Immun 63, 1158-1164.
Mizuhara H, O’Neill E, Seki N. 1994. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 179, 1529-1537.
Mohamed-Ali V, Goodrick S, Rawesh A. 1997. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82, 4196-200.
Moschen AR, Molnar C, Geiger S, Graziadei I, Ebenbichler CF, Weiss H. 2010. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor {alpha} expression. Gut 59(9), 1259-64.
Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.
Ohang AM, Halter JB. 2003. Aging and insulin secretion. Am J Physiol Endocrinol Metab 284, 7– 12.
Petersen EW, Carey AL, Sacchetti M, Steinberg GR, Macaulay SL, Febbraio MA, Pedersen BK. 2005. Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro. Am J Physiol Endocrinol Metab 288, 155–162.
Rotter V, Nagaev I, Smith U. 2003. Interleukin-6 (IL-6) induces insulin resistance in 3T3–L1 adipocytes and is, like IL-8 and TNFalpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278, 45777–45785.
Rotter V, Nagaev I, Smith U. 2003. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278, 45777-84.
Steensberg A, Fischer CP, Keller C, Moller K, Pedersen BK. 2003. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 285, 433-437.
Stouthard JM, Oude Elferink RP, Sauerwein HP. 1996. Interleukin-6 enhances glucose transport in 3T3–L1 adipocytes. Biochem Biophys Res Commun 220, 241–245.
Tilg H, Moschen AR. 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772-83.
Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, Haring HU, Schleicher ED. 2004. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasomedependent activation of nuclear factor-kappaB. J Biol Chem 279, 23942–52.
Weigert C, Hennige AM, Brodbeck K, Haring HU, Schleicher ED. 2005. Interleukin-6 (IL-6) acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser-473 of Akt. Am J Physiol Endocrinol Metab 289, 251–257.
Shahgholiabasi R, Iranshahi F, Seyedhoseini MA, Farbod M (2012), Increased IL-6 and is associated with decreased glucose concentration during cycling exercise; JBES, V2, N10, October, P40-46
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