Evaluation of the specific pharmacological activity of Padus grayana Maxim dry extract on an experimental model of staphylococcal infection in mice
Paper Details
Evaluation of the specific pharmacological activity of Padus grayana Maxim dry extract on an experimental model of staphylococcal infection in mice
Abstract
Padus grayana Maxim belongs to the family Rosaceae and one of the important herbal plants. The extract of the plant is used to treat many diseases. Hence the current study was conducted to investigate the specific pharmacological activity of Padus grayana Maxim. The extract of the plant was obtained from the dried stem, leaves, and flowers of the plant. A series of experiments were conducted to study the effect of the phytoextract on the development of staphylococcal infection in 40 outbred white mice. The results show that prophylactic administration of the dry extract of Padus grayana Maxim to mice at a dose of 200 mg/kg of body weight led to a reduction in mortality by 60% and an improvement of the clinical symptoms of staphylococcal infection in mice. After one week of using the extract of Padus grayana maxim in infected mice, the survival rate of the experimental group was higher than the control group which was 80%, and normalization of hematological parameters of peripheral blood in infected animals was also finding significantly improved. Hence, we concluded that the extract of Padus grayana maxim has significant results in the enhancement of immunity against Staphylococcus.
Abd Razak DL, Abd Ghani A, Lazim MI, Khulidin KA, Shahidi F, Ismail A. 2024. Schizophyllum commune (Fries) mushroom: a review on its nutritional components, antioxidative, and anti-inflammatory properties. Current Opinion in Food Science 56, 101129.
Appiah C, Chen S, Pori AI, Retyunskiy V, Tzeng C, Zhao Y. 2024. Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues. Frontiers in Pharmacology 15, 1359261.
Ashique S, Kumar S, Upadhyay A, Garg A, Mishra N, Kumar P, Dua K, Farid A, Hussain A. 2024. Role of synbiotics in inflammatory lung diseases. In Synbiotics in Human Health: Biology to Drug Delivery. Singapore: Springer Nature Publishing Co., p. 55–96.
Bhattacharjee B, Sandhanam K, Ghose S, Barman D, Sahu RK. 2024. Market overview of herbal medicines for lifestyle diseases. In Role of Herbal Medicines: Management of Lifestyle Diseases. Singapore: Springer Nature Publishing Co., p. 597–614.
Chen C, Chen L, Mao C, Jin L, Wu S, Zheng Y, Cui Z, Li Z, Zhang Y, Zhu S, Jiang H. 2024. Natural extracts for antibacterial applications. Small 20(9), 2306553.
Choudhary SS, Verma S. 2024. A comprehensive review on patents, herbal treatment, and clinical trials on acquired immune deficiency syndrome. Infectious Disorders-Drug Targets 24(3), 70–81.
Denny KH. 2024. Acute, subacute, subchronic, and chronic general toxicity testing for preclinical drug development. In A Comprehensive Guide to Toxicology in Nonclinical Drug Development. Academic Press, p. 149–171.
Gurib-Fakim A. 2006. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine 27(1), 1–93.
Hao Y, Zhang C, Li F, Fan Y, Chi K, Zeng H, Zhang J. 2024. Protocol for identifying stressed granulocytes from septic mice. STAR Protocols 5(2), 102958.
He Q, Wei Y, Qian Y, Zhong M. 2024. Pathophysiological dynamics in the contact, coagulation, and complement systems during sepsis: Potential targets for nafamostat mesilate. Journal of Intensive Medicine.
Jiang X, Wu L, Yang G, Gao Y, Li H. 2023. Simulation and prediction of the geographical distribution of five Caragana species in the North Temperate Zone. Environmental Monitoring and Assessment 195(12), 1427.
Kadıoğlu S, Kadıoğlu B, Karagöz K. 2024. Usage shrub and tree-form plants in traditional folk medicine. Muş Alparslan University Journal of Agriculture and Nature 4(1), 9–22.
Kessler M. 2022. A monograph of the genus Polylepis (Rosaceae). Phytokeys 203, 1–274.
Lee EL, Barnes J. 2022. Prevalence of use of herbal and traditional medicines. In Pharmacovigilance for Herbal and Traditional Medicines: Advances, Challenges and International Perspectives. Springer International Publishing Co., p. 15–25.
Liang Y, Liang Y, Wang Q, Li Q, Huang Y, Li R, Pan X, Lie L, Xu H, Han Z, Liu H. 2024. Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling. Inflammation Research 1–17.
Liu A, Garrett S, Hong W, Zhang J. 2024. Staphylococcus aureus infections and human intestinal microbiota. Pathogens 13(4), 276.
Madi C, Hsein H, Busignies V, Tchoreloff P, Mazel V. 2024. Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations. International Journal of Pharmaceutics 124059.
Neudorf H, Islam H, Falkenhain K, Oliveira B, Jackson GS, Moreno-Cabañas A, Madden K, Singer J, Walsh JJ, Little JP. 2024. Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes. Clinical and Experimental Immunology 138.
Ntwali F, Gilliaux Q, Honoré PM. 2024. Nivolumab-induced cytokine release syndrome: A case report and literature review. American Journal of Medical Case Reports 25, 941835-1.
Parnell JA. 2024. Sukid Rueangruea. Doctoral dissertation, The University of Dublin, Ireland.
Ramoni D, Tirandi A, Montecucco F, Liberale L. 2024. Sepsis in elderly patients: The role of neutrophils in pathophysiology and therapy. Internal and Emergency Medicine 1–17.
Sandeep Patil N, Ranjan A, Singh D. 2024. Regulatory procedures and integrated requirements for early phase development of a pharmaceutical drug product. Reviews on Recent Clinical Trials 19(1), 2–3.
Santana ÉT, Lima VN, Quintans JD, Coutinho HD, Lucetti EC, Tahim CM, Júnior WM, Júnior LJ. 2024. Management of pain and inflammation through natural products in individuals with knee osteoarthritis: Systematic review. Journal of Herbal Medicine 7, 100851.
Shilpi S, Chimaniya P, Saini K, Jan H, Chouhan S, Dudhekula JB, Bhatt S, Dubey AK, Saraogi G. 2024. Clinical trial with synbiotics in various disease states. In Synbiotics in Human Health: Biology to Drug Delivery. Singapore: Springer Nature Publishing Co., p. 255–280.
Solaymani-Mohammadi S. 2024. The IL-21/IL-21R signaling axis regulates CD4+ T cell responsiveness to IL-12 to promote bacterial-induced colitis. Journal of Leukocyte Biology 69.
Tian D, Chen W, Xu D, Xu L, Xu G, Guo Y, Yao Y. 2024. A review of traditional Chinese medicine diagnosis using machine learning: Inspection, auscultation-olfaction, inquiry, and palpation. Computers in Biology and Medicine 108074.
Tirant M, Tirant H, Wollina U. 2024. Herbal bioactive compounds for skin infections and inflammatory conditions. Open Access Macedonian Journal of Medical Sciences 12, 1–44.
Zhang J, Ming S, Chen X, Zhang T, Qian H, Peng S, Ding Y. 2023. Herbal medicine as adjunctive therapy with antidepressants for post-stroke depression: A systematic review and network meta-analysis of randomized controlled trials. Frontiers in Pharmacology 14, 1180071.
Murzabaeva Elvira Bolotbekovna, Shafee Ur Rehman, Ismailov Isabek Zailidinovich, Kudaibergen Osmonaliev, Sabirova Tamara Semenovna (2024), Evaluation of the specific pharmacological activity of Padus grayana Maxim dry extract on an experimental model of staphylococcal infection in mice; IJB, V25, N6, December, P485-492
https://innspub.net/evaluation-of-the-specific-pharmacological-activity-of-padus-grayana-maxim-dry-extract-on-an-experimental-model-of-staphylococcal-infection-in-mice/
Copyright © 2024
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0