Paper Details

Evaluation of immunostimulatory activity of alkaloids Mitragyna ciliata in rabbits (Oryctolagus cuniculus)

Abba Pacôme Obouayeba, Toussaint Latte, Mathurin Okoma, Sékou Diabaté, Tanoh Hilaire Kouakou

DOI: https://dx.doi.org/10.12692/ijb/5.8.200-206

Int. J. Biosci. 5(8), 200-206. October, 2014. (PDF)

Abstract:

Mitragyna ciliata (Rubiaceae) is a plant used in traditional medicine in the treatment of malaria in Côte d’Ivoire. The research for other properties in particular immunostimulatory, of this plant to strengthen malaria treatment is the cause of this study through the determination of phytochemical constituents of the methanolic extracts and the effect of its total alkaloids on cell and humoral markers of immunity of rabbit (Oryctolagus cuniculus). The immunostimulatory study was carried out with biological parameters such as white blood cells, gamma globulin, total proteins and albumin/globulin ratio. The qualitative phytochemical analysis showed the richness of this plant in phytochemical compounds. These are alkaloids, anthocyanins, flavonoids, polyphenols, saponins, sterols, terpenes and tannins. Concerning the immunostimulatory study, two major results were obtained. The first element is the fact that within a homogeneous population of rabbits, the rate of biological parameters is not a fixed value. The second element is the fact that the alkaloids Mitragyna ciliata not found to have immunostimulatory activity. However, Mitragyna ciliata remains an important medicinal plant made many pharmacological proprieties, due to the presence of its phytochemical compounds.