Paper Details

Anti-platelet aggregation assay and chemical composition of essential oil from Allium atroviolaceum Boiss  growing in Iran

Zahra Lorigooini, Farzad Kobarfard, Seyed Abdolmajid Ayatollahi

DOI: http://dx.doi.org/10.12692/ijb/5.2.151-156

Int. J. Biosci. 5(2), 151-156. July, 2014. (PDF)

Abstract:

Plants belonging to genera Allium have widely been acquired as food and medicine. Their wide use was mainly due to the medicinal properties attributed to these plants over the centuries, lately supported by epidemiological and research studies. In this study, essential oil constituents of Allium atroviolaceum growing in Shahr-e-kord, Iran, were investigated through gas chromatography/mass spectrometry (GC-MS) technique. In this essential oil two major constituents were trisulfide, di-2-propenyl (26.85%) and diallyl disulphide (10.98%) while trans-2-(2-pentenyl) furan (0.02%) and Limonene (0.06%) have been identified in lower amounts. The in-vitro antiplatelet activity of essential oil was evaluated, using arachidonic acid (AA) and adenosine diphosphate (ADP) as the platelet aggregation inducers. The results showed that essential oil of Allium atroviolaceum with IC50; 0.25 mg/ml and 0.47 mg/ml inhibited in-vitro platelet aggregation induced by AA and ADP respectively.