Antimicrobial and cytotoxic activities of the crude extracts of Callistemon linearis
Paper Details
Antimicrobial and cytotoxic activities of the crude extracts of Callistemon linearis
Abstract
The petroleum ether (PE), carbon tetrachloride (CT) and ethyl acetate (EA) soluble fractions of a crude methanol extract of Callistemon linearis and crude methanol (ME) extract itself were subjected to antibacterial and antifungal activities and cytotoxicity against brine shrimp nauplii. Present investigation revealed that the PE, CT and ME extracts have the potent to moderate sensitivity against almost all the bacteria and fungi, whereas crude EA extract showed only mild antimicrobial activity. The brine shrimp lethality with LC50 values were 8.16, 14.21, 0.42, 54.07 and 0.33µg/mL for PE, CT, ME, EA extracts and Vincristine sulphate (VS), respectively. Compare to Vincristine sulphate (standard), the cytotoxicity exhibited by the crude methanol (ME) extract was promising and this clearly indicates the presence of potent bioactive compounds in Callistemon linearis.
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