Paper Details

Serum interleukin 1-beta in sedentary healthy obese and non-obese men

Seyyed Rafi Shafabakhsh Kolor, Mona Hafezi, Reza Naseri Rad

DOI: https://dx.doi.org/10.12692/ijb/4.8.256-261

Int. J. Biosci. 4(8), 256-261. April, 2014. (PDF)

Abstract:

Obesity is associated with lowgrade systemic inflammation and plays a key role in the pathogenic mechanism of chronic diseases. This study was aimed to compare serum IL1ß between obese and nonobese men. For this purpose, fasting blood samples were obtained of fifteen sedentary obese and fifteen nonobese men matched to age and height (34 – 44 years, 170 – 180 cm) in order to measuring serum IL1ß and compare between two groups. Data of independent T test showed that serum IL1ß was significant higher in obese when compared to nonobese group (2.42 ± 0.87 obese vs 1.76 ± 0.64 nonobese, pg/ml, p= 0.026). There was no significant correlation between IL1ß and body mass index in obese subjects (p = 0.75, r= 0.09). Based on these data, we can say obesity has an inflammation property in even in healthy subjects and increased serum IL1ß may be due to disturbance of other cytokines in this population.