Paper Details

Evaluation of Polysaccharides isolated from Psyllium husk and their potential for designing controlled release floats of levoflaxacin

Abdul Karim, Tahir Mehmood, Muhammad A. Shaheen, Muhammad Imran Irfan, Qudsia Tabassam, Sehrish Shafique

DOI: https://dx.doi.org/10.12692/ijb/6.12.90-107

Int. J. Biosci. 6(12), 90-107. June, 2015. (PDF)

Abstract:

The present investigation deals with the development and optimization of gastro-retentive tablets of levoflaxacin. The psyllium husk gel was isolated and further fractionated using solvent technique. The isolated polysaccharides fractions were used as matrix for tablet formulation and characterized by techniques FTIR, TGA and GPC. Tablets prepared by effervescence technique were characterized by SEM, and FTIR spectroscopy for surface morphology and excipients–drug interaction analysis respectively. The psyllium gel fractions in combination with stearic acid, linseed gel and tragacanth were selected as independent variables for different batches. Levoflaxacin floats were prepared by direct compression technique and evaluated for drug content, uniformity of weight, friability, buoyancy and in vitro drug release studies. Optimized formulations were selected using mathematical tools (kinetic study & linear regression analysis) to determine the effect of variables and closeness amongst predicated and experimental drug release data. The acetic acid extracted fraction (ANa) was found to be most drug release retardant and formulation S4F1 was found to be most suitable due to better swelling ability, lag time, drug release retarding ability and best fitness to Higuchi’s square root model (R2 = 0.976) and power law (R2 = 0.971). The value of n = 0.476 showing that the drug release pattern was found to be Fickian diffusion.