Paper Details

Diabetes phenomena can not affect serum ghrelin in obese individuals

Torabi Mohsen, Baghery Hadi, Falah Ahmad

DOI: https://dx.doi.org/10.12692/ijb/4.2.327-332

Int. J. Biosci. 4(2), 327-332. January, 2014. (PDF)

Abstract:

Ghrelin is an acylated 28-amino-acid peptide plays role in glucose homeostasis, although the molecular basis of this relationship is not fully known yet. This study aimed to compare serum ghrelin between diabetes and no diabetes population and to determine relation between ghrelin with glucose in diabetes patient. For these purpose, fasting serum ghrelin, insulin, glucose and insulin sensitivity were measured in twelve adult obese men with or without type II diabetes. Independent student t test was used for between groups comparison. Pearson correlations were used to establish the relationship between serum ghrelin with glucose and insulin sensitivity in diabetic patients. A p-value less than 0.05 were considered statistically significant. No significant differences were observed in anthropometrical markers between two groups (p ≥ 0.05). Serum ghrelin was not difference between two groups (p = 0.385). Fasting glucose was significant higher (p < 0.001) and insulin sensitivity was significant lower (p < 0.001) in diabetes subjects. Positive correlation was observed between serum ghrelin and glucose concentration in studied patients (p= 0.006, r= 0.74). Based on these data, we conclude that diabetes phenomena can not affect serum ghrelin in obese individuals.